The Migration of <i>Eimeria acervulina</i> Sporozoites to the Duodenal Glands of Lieberkühn

Doran, David J.

doi:10.1111/j.1550-7408.1966.tb01864.x

Cited by 45 publications

(18 citation statements)

References 7 publications

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“…Thus the mast cell response in chickens seems to be related to the time, when sporozoites penetrate the in testine [2] and not to the immune status of the bird or to changes in intestinal permea bility. In the challenged immune rats there was no change in mast cell numbers detecta ble 3-7 h after dosing and no leakage of dye at these times, but numbers of mast cells were increased 2 and 6 days later.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Mast Cell Response in Rats and Chickens to Coccidiosis, with Some Properties of Chicken Mast Cells

Rose¹,

Ogilvie²,

Bradley³

1980

Int Arch Allergy Immunol

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The response of intestinal mast cells to infection with coccidian protozoa in rats and chickens was compared with the well-known increase in the numbers of these cells which follows helminth infections. In Eimeria-infected chickens and rats given a moderate primary infection, there was an initial fall in the numbers of intestinal mast cells, small and insignificant in the rats, but more marked in the chickens. This was followed, towards the end of infection, by a return to (chicken) or an increase above (rat) normal levels. In birds given a large challenge inoculum of oocysts there was, within hours of dosing, an initial increase in numbers followed by a return to normal by day 2 and this response was similar in both immunised and susceptible birds. This rapid recruitment of cells was not seen in immune rats similarly challenged: in this species numbers were not increased until day 2 at the earliest. A marked increase in vascular leakage after the large challenge inoculum was apparent only in immunised birds. Thus this could not be correlated with the increase in numbers of mast cells which occurred equally in both immune and susceptible and was probably related to the invasion of host cells by the parasite. The mast cells of chickens are not degranulated by polymyxin B or compound 48/80, both of which affect rat mast cells. In the rat, connective tissue and intestinal mast cells differ in various ways including their dye-binding properties, but this was not seen with chicken mast cells.

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Section: Discussionmentioning

confidence: 99%

Intestinal Mast Cell Response in Rats and Chickens to Coccidiosis, with Some Properties of Chicken Mast Cells

Rose¹,

Ogilvie²,

Bradley³

1980

Int Arch Allergy Immunol

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“…Early reports described E. necatrix sporozoites as migrating through the lamina propria toward the muscularis mucosa and becoming engulfed by macrophages en route (Van Doornick & Becker, 1956). Eimeria acervulina was reported to be transported to the crypts in host cells described as macrophages (Doran, 1966), although the identity of the cells was not confirmed. Lawn & Rose (1982) reported that E. tenella sporozoites are transported from the surface epithelium to the crypts in intraepithelial lymphocytes (IEL).…”

Section: Sporozoite Invasion and Transportmentioning

confidence: 99%

Coccidia: A review of recent advances on immunity and vaccine development

1993

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“…In the case of chicken coccidia, it is commonly admitted that sporozoites enter the villous epithelial cells of the target organ directly. They then migrate within the same villus; and it has been demonstrated that this migration occurs either in intraepithelial lymphocytes (IEL;Lawn et al 1982;Al-Attar and Fernando 1987;Fernando et al 1987), or in some cases in macrophages (Doran 1966;Michael 1976;Fernando et al 1987).…”

Section: Introductionmentioning

confidence: 99%

Tissues and cells involved in the invasion of the rabbit intestinal tract by sporozoites of Eimeria coecicola

Renaux¹,

Drouet-Viard²,

Chanteloup³

et al. 2001

Parasitology Research

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This study was designed to identify an extra-intestinal route of migration of Eimeria coecicola sporozoites and the types of cell harbouring the parasite during the invasion of the intestine. The presence of E. coecicola in blood, spleen and mesenteric lymph nodes of infected donor rabbits was demonstrated by immunohistology on donor organs and measurement of oocyst excretion by coccidia-free recipient rabbits injected with whole-cell suspensions prepared from donor tissues. Two types of donor lymphocyte, B (IgM+) and T (CD5+), were labelled using a two-colour immunofluorescence-labelling technique and separated with a cell-sorter (FACStar(Plus)). The presence of parasites in the sorted cells was assessed by direct examination and by using the same in vivo test after intravenous injection of IgM+ B or CD5+ T lymphocytes collected from donors at different times after inoculation. This test provided evidence that the parasites were alive and still infectious within the sorted lymphocytes. It was demonstrated that both B and T lymphocytes were infected.

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The Migration of Eimeria acervulina Sporozoites to the Duodenal Glands of Lieberkühn

Cited by 45 publications

References 7 publications

Intestinal Mast Cell Response in Rats and Chickens to Coccidiosis, with Some Properties of Chicken Mast Cells

Intestinal Mast Cell Response in Rats and Chickens to Coccidiosis, with Some Properties of Chicken Mast Cells

Coccidia: A review of recent advances on immunity and vaccine development

Tissues and cells involved in the invasion of the rabbit intestinal tract by sporozoites of Eimeria coecicola

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