The Mini-Mental State Examination in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia

Osher, Jason E.; Wicklund, Alissa H.; Rademaker, Alfred; Johnson, Nancy; Weıntraub, Sandra

doi:10.1177/1533317507307173

Cited by 57 publications

(61 citation statements)

References 26 publications

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“…Moreover, patients may have good compensatory abilities, which help them cope with aphasic problems in daily life. These findings are in line with Osher et al (2008), and Mioshi et al (2007). Clinicians should take this verbal handicap into account when testing cognitive status in people with aphasia and make better use of non-verbal cognitive tests like the Aphasia Check List (ACL) (Kalbe et al, 2005).…”

Section: Discussionsupporting

confidence: 73%

Association between cognition and daily life functioning in dementia subtypes

Bouwens

Heugten

Verhey

2009

Int J Geriat Psychiatry

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The association between cognition and daily life functioning varied among dementia subtypes for AD, VaD, FTD and PD. Furthermore, the overall scores on both domains differ between dementia subtypes, indicating that different types of dementia are characterized by a specific pattern of cognitive status and daily life functioning. These findings underline the need for multidomain assessment in patients with dementia.

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Section: Discussionsupporting

confidence: 73%

Association between cognition and daily life functioning in dementia subtypes

Bouwens

Heugten

Verhey

2009

Int J Geriat Psychiatry

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“…It suffers from both floor and ceiling effects [26], though these should not be of particular concern for the trials included in this study. In addition, it is particularly suitable for measuring the cognitive deficits observed in AD and may be less sensitive to those in VaD [27] or FTD [28]. However, the latter has little impact in the current review, since only one included trial concerned FTD and, as mentioned, no significant differences were found between AD and VaD subgroups in the meta-regressions.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

Knight¹,

Khondoker²,

Magill³

et al. 2018

Dement Geriatr Cogn Disord

132

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Background: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores. Summary: Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia/ dementia with Lewy bodies (2.11 MMSE points at 6 months) as for patients with Alzheimer disease/vascular dementia (0.91 MMSE points at 6 months). Key Messages: AChEIs demonstrate a modest effect versus control on MMSE scores which is moderated by dementia subtype. For memantine the effect is smaller.

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“…Twenty-two of the 26 PPA participants achieved a score of 24 or higher on the MMSE, indicating normal performance. The re-maining four achieved scores between 16 and 23, suggesting mild impairment, (but importantly, scores on this measure are influenced by patients' compromised language ability [23,45]). …”

Section: Experiments 1 Patterns Of Sentence Comprehension and Productionmentioning

confidence: 99%

Syntactic and Morphosyntactic Processing in Stroke-Induced and Primary Progressive Aphasia

Thompson

Meltzer‐Asscher

Cho

et al. 2013

Behavioural Neurology

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Abstract. The paper reports findings derived from three experiments examining syntactic and morphosyntactic processing in individuals with agrammatic and logopenic variants of primary progressive aphasia (PPA-G and PPA-L, respectively) and strokeinduced agrammatic and anomic aphasia (StrAg and StrAn, respectively). We examined comprehension and production of canonical and noncanonical sentence structures and production of tensed and nontensed verb forms using constrained tasks in experiments 1 and 2, using the Northwestern Assessment of Verbs and Sentences (NAVS [57]) and the Northwestern Assessment of Verb Inflection (NAVI, Thompson and Lee, experimental version) test batteries, respectively. Experiment 3 examined free narrative samples, focusing on syntactic and morphosyntactic measures, i.e. production of grammatical sentences, noun to verb ratio, open-class to closed-class word production ratio, and the production of correctly inflected verbs. Results indicate that the two agrammatic groups (i.e., PPA-G and StrAg) pattern alike on syntactic and morphosyntactic measures, showing more impaired noncanonical compared to canonical sentence comprehension and production and greater difficulties producing tensed compared to nontensed verb forms. Their spontaneous speech also contained significantly fewer grammatical sentences and correctly inflected verbs, and they produced a greater proportion of nouns compared to verbs, than healthy speakers. In contrast, PPA-L and StrAn individuals did not display these deficits, and performed significantly better than the agrammatic groups on these measures. The findings suggest that agrammatism, whether induced by degenerative disease or stroke, is associated with characteristic deficits in syntactic and morphosyntactic processing. We therefore recommend that linguistically sophisticated tests and narrative analysis procedures be used to systematically evaluate the linguistic ability of individuals with PPA, contributing to our understanding of the language impairments of different PPA variants.

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The Mini-Mental State Examination in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia

Cited by 57 publications

References 26 publications

Association between cognition and daily life functioning in dementia subtypes

Association between cognition and daily life functioning in dementia subtypes

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

Syntactic and Morphosyntactic Processing in Stroke-Induced and Primary Progressive Aphasia

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