The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia

Gutiérrez-Camino, Ángela; Oosterom, Natanja; Hoed, Marissa A. H. den; López-López, Elixabet; Martín-Guerrero, Idoia; Pluijm, Saskia M. F.; Pieters, Rob; Jonge, Robert de; Tissing, Wim J. E.; Heil, Sandra G.; Garcı́a-Orad, Africa; Heuvel‐Eibrink, Marry M. van den

doi:10.1097/fpc.0000000000000291

Cited by 30 publications

(32 citation statements)

References 13 publications

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“…In addition, Gutierrez et al . reported that rs2114358 CC genotype was associated with a 4.6-fold increased likelihood of developing methotrexate-induced oral mucositis in a prospective Dutch cohort of pediatric acute lymphoblastic leukemiapatients [ 24 , 25 ]. In this study, we found that rs2114358 was closely related to the occurrence of adverse events in the advanced colon cancer patients treated by capecitabine, which further expands our understanding of the regulatory role of this polymorphism in tumor.…”

Section: Discussionmentioning

confidence: 99%

The SNPs in pre-miRNA are related to the response of capecitabine-based therapy in advanced colon cancer patients

et al. 2017

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The single nucleotide polymorphisms (SNPs) in the microRNA precursor (pre-miRNA) may modulate the posttranscriptional regulation of gene expression and explain individual sensitivity to chemotherapy. Here we investigated the correlation between 23 SNPs in the pre-miRNA and the efficacy of capecitabine-based chemotherapy in 274 advanced colon cancer patients. Statistical analysis indicated that much more patients with rs744591 A/C(48.03%), C/C (53.45%) or C allele (49.73%) responded to the chemotherapy than those with the A/A genotype (33.71%). The response rates of rs745666 G/C heterozygous patients (35.25%) and C allele carriers (39.69%) were apparently less than that of the G/G homozygous patients (56.25%). Moreover, three SNPs rs2114358, rs35770269, and rs73239138 were significantly associated with the occurrence of side effects of chemotherapy. The patients with rs2114358 C allele (OR = 2.016) or rs35770269 T allele (OR = 2.299) were much more prone to endure adverse events. However, the incidence of side effect was lower in the patients carrying rs73239138 A allele than those with G/G genotype (OR = 0.500). Our findings demonstrate that genetic variations in pre-miRNA may influence the efficacy of capecitabine-based chemotherapy in advanced colon cancer patients.

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Section: Discussionmentioning

confidence: 99%

The SNPs in pre-miRNA are related to the response of capecitabine-based therapy in advanced colon cancer patients

et al. 2017

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“…In 2017, Gutierrez-Camino and colleagues have identified a significant correlation between the presence of SNP rs10505168 in the sequence of miR-2053 and an increased risk to develop OM in children undergoing methotrexate treatment for pediatric acute lymphoblastic leukemia (ALL) treatment [147].…”

Section: Biomarker Feasibility For Oral Mucositis Development Risk Asmentioning

confidence: 99%

Oral mucositis: the hidden side of cancer therapy

Pulito¹,

Cristaudo

Porta

et al. 2020

J Exp Clin Cancer Res

241

135

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Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy develop mucositis; this percentage rises to about 90% for head and neck cancer patients (HNC) treated with both chemo- and radiotherapy. 19% of the latter will be hospitalized and will experience a delay in antineoplastic treatment for high-grade mucositis management, resulting in a reduction of the quality of life, a worse prognosis and an increase in patient management costs. Currently, several interventions and prevention guidelines are available, but their effectiveness is uncertain. This review comprehensively describes mucositis, debating the impact of standard chemo-radiotherapy and targeted therapy on mucositis development and pointing out the limits and the benefits of current mucositis treatment strategies and assessment guidelines. Moreover, the review critically examines the feasibility of the existing biomarkers to predict patient risk of developing oral mucositis and their role in early diagnosis. Despite the expression levels of some proteins involved in the inflammation response, such as TNF-α or IL-1β, partially correlate with mucositis process, their presence does not exclude others mucositis-independent inflammation events. This strongly suggests the need to discover biomarkers that specifically feature mucositis process development. Non-coding RNAs might hold this potential.

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“…Other miRNAs, including miR‐1206, has a potential role in childhood ALL. Previous studies have established the involvement of rs2114358 polymorphism in miR‐1206, contributing to the methotrexate‐induced oral mucositis . miR‐223 regulates myeloid genes and is highly expressed in myeloid‐like ALL patients .…”

Section: A General Review Concerning Mirnas Involvement In the Pathogmentioning

confidence: 99%

The role of microRNAs in acute lymphoblastic leukaemia: From biology to applications

Tapeh

Alivand

Solali

2019

Cell Biochemistry & Function

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MicroRNAs (miRNAs) that are characterized by small, noncoding RNA have an essential role in the pathogenesis of human diseases, including cancer. Furthermore, miRNAs, as a new paradigm of epigenetic regulators, play an important role in normal development and cellular function. This literature review summarizes the recurrent mechanism of gene regulation through miRNAs and, consequently, the impact of regulated genes on different cellular processes, including proliferation, metastasis, prognosis, and apoptosis. Additionally, what is important to note is that the expression of miRNAs in various cancer cells is different, and miRNAs have various target genes in various cancers. Accordingly, a proper understanding of gene regulation by miRNAs contributes to new perspectives in miRNA‐based therapeutic strategies. Significance of the study MiRNAs are considered as a crucial regulator of gene expression. The genes also play an important role in the expression of miRNAs; as a result, there is a relationship between them. In recent years, targeted therapy with miRNAs has been a significant challenge. Studying the mechanisms through which miRNAs regulate various cancer cell processes, including apoptosis, proliferation, and metastasis, is very critical in the treatment of cancer through miRNAs. Definitely, a proper understanding of the impacts of aberrant expression of miRNAs on cancer cell processes leads to new therapeutic strategies in the targeted therapy with miRNAs.

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The miR-1206 microRNA variant is associated with methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia

Cited by 30 publications

References 13 publications

The SNPs in pre-miRNA are related to the response of capecitabine-based therapy in advanced colon cancer patients

The SNPs in pre-miRNA are related to the response of capecitabine-based therapy in advanced colon cancer patients

Oral mucositis: the hidden side of cancer therapy

The role of microRNAs in acute lymphoblastic leukaemia: From biology to applications

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