The MitraClip Experience and Future Percutaneous Mitral Valve Therapies

Bhamra-Ariza, Paul; Muller, David W.M.

doi:10.1016/j.hlc.2014.05.021

Cited by 9 publications

(8 citation statements)

References 40 publications

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“…In the current report, the TEER, an example of a minimally invasive device, was successfully implanted in two healthy dogs. The operation time was approximately one hour to one and a half hours, which is much shorter than the time required for valvuloplasty under extracorporeal circulation conditions [ 15 , 23 , 24 ]. Additionally, the postoperative recovery was rapid, and less postoperative management was required.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Changes in the Cardiac Function before and after Transcatheter Edge-to-Edge Mitral Valve Repair in Healthy Dogs: Conventional and Novel Echocardiography

Sasaki

Mandour

et al. 2021

Animals

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Mitral valve regurgitation is a common canine heart disease. Transcatheter Edge-to-Edge Repair (TEER) is a transcatheter, edge-to-edge mitral repair device that uses a hybrid approach. No detailed information has been published on the hemodynamic effect of TEER on cardiac function. The aim of this report is to provide a longitudinal observation of the cardiac functional changes observed after TEER implantation in normal dogs using traditional, two-dimensional speckle tracking, and color M-mode echocardiographic methods. In the current report, TEER was implanted into two healthy dogs under general anesthesia. An echocardiographic examination was performed at baseline and weekly postoperative follow-ups were conducted until the fourth week. Successful TEER implantation was achieved with a short operation time (98 and 63 min) in the two dogs. Functional mitral valve regurgitation, elevated E/e’ ratio, elevated radial strain, and stable intraventricular pressure gradients (IVPG) were observed after the operation in the dogs. Mild non progressive mitral valve stenosis was observed in both dogs. TEER is a minimally invasive method for mitral valve surgery that necessitates more clinical trials. With longitudinal observation of heart function using novel approaches, better outcomes will be expected.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Changes in the Cardiac Function before and after Transcatheter Edge-to-Edge Mitral Valve Repair in Healthy Dogs: Conventional and Novel Echocardiography

Sasaki

Mandour

et al. 2021

Animals

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“…Although right ventricle is initially normal, increased RV pressures caused by longstanding pulmonary hypertension lead to progressive RV systolic dysfunction. Echocardiographic detection of FMR in NICMP plays a critical role in preventing irreversible RV failure by optimizing medical therapy as well as by timing for possible interventions, such as surgical or percutaneous mitral repair (14)(15)(16)(17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Right Ventricular Systolic Dysfunction in Non-Ischemic Dilated Cardiomyopathy: An Echocardiographic Study

Karaca¹,

Avcı²,

Babur³

et al. 2016

Int Cardiovasc Res J

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A B S T R A C TBackground: Right Ventricular (RV) functions are known to have an impact on determining the prognosis of patients with Non-Ischemic Dilated Cardiomyopathy (NICMP). Objectives: This study aimed to investigate the echocardiographic determinants of RV systolic dysfunction in patients with NICMP. Patients and Methods: This cross-sectional study was conducted on 79 patients with angiographically normal coronary arteries (mean age: 50.5 ± 12, mean Ejection Fraction (EF): 31 ± 4%) selected through purposive sampling The patients were divided into two groups based on their RV systolic function determined by tissue Doppler systolic velocities (RV-Sm): group A (RV-Sm ≥ 10 cm/s, N = 48) and group B (RV-Sm < 10 cm/s, N = 31). The two groups were compared regarding clinical, demographic, and echocardiographic variables using independent t-test and chi-square test. Results: The patients with RV systolic dysfunction were found to have higher Brain Natriuretic Peptide (BNP) values (P = 0.006) and worse functional status (New York Heart Association (NYHA) III-IV, P = 0.04) compared to group A. Besides, univariate analysis of the echocardiographic parameters revealed that the patients in group B had significantly (all P values < 0.05) higher Left Atrial Volume Index (LAVI), higher degree of left ventricular diastolic dysfunction (represented by LV-E/Em), higher degree of Functional Mitral Regurgitation (FMR), higher estimated Pulmonary Artery Systolic Pressure (PASP), and higher degree of RV diastolic dysfunction (represented by RV-E/ Em) Moreover, multivariate logistic regression analysis showed that severe FMR (P = 0.006) and RV-E/Em (P = 0.016) predicted RV systolic dysfunction independently. Conclusions: Advanced FMR and worse RV diastolic functions emerged as the independent predictors of RV systolic dysfunction in NICMP correlating to functional status and BNP levels.

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“…However, its results with BD still remain obscure. While the device is frequently used for degenerative mitral valve regurgitation, successes with BD patients have remained low [63][64][65]. The surgical technique which the MitraClip mimics has shown favorable results for BD.…”

Section: Future Directionsmentioning

confidence: 99%

“…The surgical technique which the MitraClip mimics has shown favorable results for BD. However, a formal study as to the outcomes and survival of BD patients that undergo MitraClip placement has not been performed [63][64][65][66]. The other new intervention is transcatheter mitral valve implantation (TMVI) [67].…”

Section: Future Directionsmentioning

confidence: 99%