There have been considerable recent technological developments for implant overdenture attachments. This study presents an overview of the biomechanical and biomolecular aspects of various attachments for implant overdenture. Available articles on attachments for implant overdenture were reviewed from January 1980 to August 2021 in the ScienceDirect, MEDLINE/PubMed, and Web of Science resources, and relevant studies were included in this study. We focused on the following topics: attachment systems, retention of various attachments, stress distribution with different attachments, the design and fabrication of attachments, digital techniques in overdenture attachments, and the effects of attachments in peri-implant health. We found that plastic resin is commonly used for ball and bar attachments, whereas nylon resin is commonly used in locator attachments. The locator system offers a valuable attachment option for implant-retained overdenture. Attachment retention reduces while lateral force increases with implant inclination in overdenture. The higher the retention of an overdenture attachment, the higher the transferred stresses. Additionally, clip loading produces more stress in implants and precision elements than bar-retained dentures. As such, we conclude that the ball and locator systems the best overdenture systems due to their superior tissue response, survival rate, and patient satisfaction.