The Modern Epidemic of Syphilis

Ghanem, Khalil G.; Ram, Sanjay; Rice, Peter A.

doi:10.1056/nejmra1901593

Cited by 308 publications

(362 citation statements)

References 62 publications

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“…Thus, compared with the first quarter of 2019, in the first quarter of 2020, the number of syphilis diagnoses doubled among PLWH and increased fourfold among MSM, a finding consistent with the epidemic trends highlighted in the literature. [1][2][3] The fear of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have reduced sexual encounters and led to a genuine decline in STIs. However, we cannot exclude that patients have been postponing their visits because of worries about attending the clinic during the pandemic, as also described for other medical specialities.…”

Section: Research Lettermentioning

confidence: 99%

Is COVID-19 affecting the epidemiology of STIs? The experience of syphilis in Rome

et al. 2020

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Section: Research Lettermentioning

confidence: 99%

Is COVID-19 affecting the epidemiology of STIs? The experience of syphilis in Rome

et al. 2020

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“…It is an STD that can also be transmitted vertically. [ 3 4 ] It is estimated that there are 5.6 million new cases every year with highest rate in Africa. [ 3 ] Centers for Disease Control and Prevention (CDC) reported that in 2018 there were 115,000 cases of syphilis and ~1300 cases of congenital syphilis in the United States yielding 13.3% and 39.7% rate increase prospectively comparing with 2017.…”

Section: Discussionmentioning

confidence: 99%

“…However, neurosyphilis generally develops more in patients with HIV, especially those who are untreated, have low CD4+ counts, or have detectable HIV RNA levels. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Onychoptosis: A forgotten sign in syphilis infection

2020

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Onychoptosis is the periodic shedding and falling of one or more nails, in whole or part. It can be seen after fever, trauma, adverse reaction to medications, and in systemic illnesses including syphilis (syphilitic onychia). We report a case of 38-year-old man presented with subacute bilateral retrobulbar optic neuritis. Physical examination revealed diffuse onychoptosis which lead into the diagnosis of neurosyphilis. Symptoms significantly improved with appropriate treatment with intravenous penicillin G for 14 days.

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“…Зокрема, в США мало місце подвоєння частоти первинного і вторинного сифілісу в жінок з 2014 до 2018 рр., що позначилось зростанням випадків вродженого сифілісу (ВС) і смертності немовлят [5]. В подальшому аналіз ситуації показав, що зростання частоти ВС значною мірою обумовлене недостатньою якістю пренатального скринінгу або неадекватним лікуванням інфікованих вагітних [6].…”

Section: сучасні підходи до діагностики сифілісу при вагітностіunclassified

“…Реакція Вассермана (експрес-діагностика сифілісу) не використовується в Європі з 80-х років через низьку специфічність і чутливість. Характеристики сучасних ТТ і НТТ на сифіліс представлені в таблиці 2, з якої видно, що вони надають взаємодоповнюючі дані [6,[13][14][15][16].…”

Section: лабораторна діагностика сифілісу під час вагітностіunclassified

Change of emphasis in the structure of prenatal infections, or what is SCORTCH? Literature review

Тутченко

Бурка

Коломієць

et al. 2020

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Prenatal infections (PI) remain an actual problem. Taking into account the epidemiological data on the increase in the incidence of syphilis in many countries, a review of modern algorithms for diagnosing this disease in pregnant women and newborns has been carried out. Universal screening for syphilis at the first prenatal examination is recommended by WHO and CDC, and is practiced in most countries. The article also presents the characteristics of modern laboratory methods of serological screening of pregnant women for syphilis and their combinations, one of which is primary screening using the treponemal test “total antibodies to syphilis” with confirmation of a positive result by immunoblotting.Given the controversial nature of approaches to the prevention of other PI and their consequences, this review provides current recommendations for countries that screen and actively manage infections such as cytomegalovirus (CMV) and toxoplasmosis (T). Despite the proven significance of CMV as a factor in PI, universal prenatal screening, similar to screening for syphilis is not practiced in any of the countries due to the absence of prenatal treatment with proven efficacy. According to the national protocol of Germany, serostatus (titers IgG, IgM) to CMV are determined in early pregnancy. Confirmation of congenital CMV infection (HCMVI) is a positive PCR result in the amniotic fluid after 20–21 weeks of gestation. The main method of laboratory diagnostics of HCMVI in a newborn is PCR for CMV in urine. The article also presents the main approaches to the prevention of congenital toxoplasmosis, which have been practiced in France since the 90s and demonstrate effectiveness.Thus, despite the fact that the use of effective prenatal treatment is not possible for all PI, their diagnosis using a complex of modern laboratory and instrumental methods is critical for the child’s health, since it allows the application of an appropriate algorithm for specific treatment and observation from birth

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The Modern Epidemic of Syphilis

Cited by 308 publications

References 62 publications

Is COVID-19 affecting the epidemiology of STIs? The experience of syphilis in Rome

Is COVID-19 affecting the epidemiology of STIs? The experience of syphilis in Rome

Onychoptosis: A forgotten sign in syphilis infection

Change of emphasis in the structure of prenatal infections, or what is SCORTCH? Literature review

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