The Modification of Serum Lipids after Acute Coronary Syndrome and Importance in Clinical Practice

Abstract

Atherosclerosis is a pathology characterized by low-grade vascular inflammation rather than a mere accumulation of lipids. Inflammation is central at all stages of atherosclerosis. Acute coronary syndrome significantly affects the concentration and composition of the lipids and lipoproteins in plasma. Plasma triglyceride and very low density lipoprotein levels increase, while high density lipoprotein, low density lipoprotein and total cholesterol levels decrease. Early treatment of hyperlipidemia provides potential benefits. However, post-event changes in lipid and lipoproteins lead to delays in the choice of the treatment. This review focuses on the mechanism and the clinical importance of the relevant changes.

Acute phase reactants and lipid profile in acute chest pain presentations: a multimarker approach

“…The deposition of LDL into the sub-endothelial space creates a tendency for LDL to be exposed to oxidation. 34 Under conditions of high oxidant stress there is increased peroxidation of lipoprotein phospholipids, thereby increasing the LDLuptake by macrophages with increased foam cell formation and atherosclerosis, initiating a potent inflammatory response in the process observed in the form of increased serum ferritin levels. 35 Our finding correlates with prior studies, where it was observed that patients with chest pain and positive cardiac enzyme test were found to have significantly elevated levels of serum ferritin when compared to healthy controls.…”

“…There is a decrease in levels of several plasma proteins included in HDLmediated reverse transport of cholesterol and inhibition of lipid oxidation during inflammation. 34 The idea that there is an early modification in serum lipids and lipoproteins, brings the thought that their estimations are unreliable, as they undergo phasic changes post-MI. Therefore, it is difficult to find the patients' baseline lipid profile correctly.…”

Association Between Age, Body Mass Index, Waist Circumference, Lipid Profile Parameters, and Symptomatic Bacterial Urinary Tract Infection in Iraqi Adult Women

“…The inconsistent finding was reported by Gordon et al [39] who mentioned that in the critically ill patients, the mean serum TG concentration was higher in patients with an infection compared to patients without infection, but these differences were not statistically significant. It is known that the changes in lipids and lipoproteins in the course of many disorders characterized by infection and inflammation [11]. Urinary tract infections cause oxidative stress.…”

“…The levels of lipid and lipoproteins change during acute illness [11]. It is known that there are changes in lipids and lipoproteins in the course of many disorders.…”

Prevalence of Conventional Risk Factors and Lipid Profiles of Patients with First Day of Acute Coronary Syndrome Admitted in CCU of Gandaki Medical College Teaching Hospital, Pokhara, Nepal

“…It has been recognized that alteration in lipid level consists of decrease in total cholesterol, LDL-C and increased triglyceride after ACS 1,19 . There is strong association between risk factors and occurrence of coronary artery disease 7,9,14 .…”