The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial

Kodarahmian, Mahshad; Amidi, Fardin; Moini, Ashraf; Kashani, Ladan; Nashtaei, Maryam Shabani; Pazhohan, Azar; Bahramrezai, Mojdeh; Berenjian, Samaneh; Sobhani, Aligholi

doi:10.1080/09513590.2019.1576612

Cited by 34 publications

(38 citation statements)

References 44 publications

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“…Resveratrol is considered to be effective in preventing and treating endometriosis. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 In the present study, we showed that resveratrol inhibited the proliferation, migration, and invasion of ESCs in cell cultures ( Figures 4 A, 4C, and 4E) and suppressed the growth of ectopic endometrium in the mouse endometriosis model ( Figure 7 B). Then, we demonstrated that resveratrol decreased MTA1 expression and suppressed EMT induced by MTA1-ZEB2 in endometrial cells ( Figure 3 G) and endometriosis mice ( Figures 7 C and 7D).…”

Section: Discussionsupporting

confidence: 60%

“… 11 , 12 , 13 , 14 It is also effective in treating endometriosis. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 Resveratrol not only increases antioxidant capacity and decreases lipid peroxidation, 15 but it also exhibits anti-inflammatory activity by suppressing nuclear factor κB (NF-kB), tumor necrosis factor (TNF)-α, and inflammatory cytokines in endometriosis. 20 More importantly, resveratrol has the activities of anti-proliferation and anti-invasion in endometriosis through inhibiting the expressions of VEGF, MMP-2, and MMP-9.…”

Section: Introductionmentioning

confidence: 99%

“… 20 More importantly, resveratrol has the activities of anti-proliferation and anti-invasion in endometriosis through inhibiting the expressions of VEGF, MMP-2, and MMP-9. 17 , 18 , 19 Studies have shown that resveratrol enhances cells apoptosis and inhibits prostate cancer progression via suppressing the MTA1/NuRD complex. 23 , 24 Thus, we speculated whether resveratrol has therapeutic effects in endometriosis through interaction with MTA1.…”

Section: Introductionmentioning

confidence: 99%

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MTA1, a Target of Resveratrol, Promotes Epithelial-Mesenchymal Transition of Endometriosis via ZEB2

Kong

Zhou

et al. 2020

Molecular Therapy - Methods & Clinical Development

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Endometriosis is a benign disease that shares some malignant features. Epithelial-mesenchymal transition (EMT) is involved in the pathogenesis of endometriosis. Metastasis-associated protein 1 (MTA1) plays an important role in various cancers by promoting EMT, yet there are no studies on its function in endometriosis. In the present study, we found that MTA1 was highly expressed in the ectopic endometrium of endometriosis patients and that the expression of MTA1 was related to the revised American Fertility Society stage. MTA1 facilitated endometrial stroma cell proliferation, migration, and invasion by inducing EMT, and the promotion function and MTA1 expression were suppressed by resveratrol, a natural polyphenol. Moreover, we revealed that MTA1 induced EMT through interaction with ZEB2. The findings in a mouse endometriosis model further showed that MTA1 and ZEB2 were upregulated in ectopic tissues and that resveratrol inhibited the growth of ectopic lesions and expression of MTA1 and ZEB2. Taken together, we demonstrate that MTA1 is a protein that promotes EMT via interacting with ZEB2 in the pathogenesis of endometriosis, and may be a target of resveratrol.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MTA1, a Target of Resveratrol, Promotes Epithelial-Mesenchymal Transition of Endometriosis via ZEB2

Kong

Zhou

et al. 2020

Molecular Therapy - Methods & Clinical Development

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“…This review discusses the following: endometriosis is constantly exposed to environmental stressors, such as superoxide anions; superoxide is one of important mediators in persistent pain [7,14,27,43,60,75,87,89,104]; and some compounds and natural substances that suppress the pain caused by superoxide may be potential candidates for nonhormonal therapy for endometriosis [82,84,85,[91][92][93][94][95][96][97][98][99][100][101][102][103]. First, we summarize the mechanism by which superoxide anion is produced in large amounts in endometriosis and thus contributes to pain (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…This phenol has been shown to suppress the expression of various inflammatory biomarkers (TNF-α and COX-2), activate transcription factors (NF-kB and PPAR-gamma), and induce antioxidant enzymes (catalase and SOD) [91]. Resveratrol is currently considered a new innovative drug in the prevention and treatment of endometriosis and has been undergoing various clinical trials [82, 95]. Maia et al [84] reported prospective study with 2 arms: a patient was treated with drospirenone (3 mg) and ethinyl estradiol (0.03 mg) in combination with resveratrol (a dose of 30 mg/day) for 6 months.…”

Section: Methodsmentioning

confidence: 99%

Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance

Nagayasu

Imanaka

Kimura

et al. 2021

Gynecol Obstet Invest

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The aim of this review is to investigate the oxidant/antioxidant status and its regulatory mechanisms in patients with endometriosis and to summarize the antioxidant therapy as an alternative to hormonal therapy for endometriosis. Each keyword alone or in combination was used to search from PubMed and Embase by applying the filters of the title and the publication years between January 2000 and March 2020. Endometriosis is a chronic inflammatory disease characterized by repeated episodes of hemorrhage. Methemoglobin in repeated hemorrhage produces large amounts of superoxide anion via the autoxidation of hemoglobin. Excessive free-radical production causes redox imbalance, leading to inadequate antioxidant defenses and damage to endometrial cells, but may contribute to endometrial cell growth and survival through activation of various signaling pathways. In addition, to overcome excessive oxidative stress, estradiol participates in the induction of antioxidants such as superoxide dismutase in mitochondria. Several antioxidants that suppress free radicals may be effective in endometriosis-related pain. We searched for 23 compounds and natural substances that could reduce the pain caused by superoxide/reactive oxygen species in basic research and animal models. Next, we built a list of 16 drugs that were suggested to be effective against endometriosis other than hormone therapy in preclinical studies and clinical trials. Of the 23 and 16 drugs, 4 overlapping drugs could be potential candidates for clinically reducing endometriosis-related pain caused by superoxide anion/reactive oxygen species. These drugs include polyphenols (resveratrol and polydatin), dopamine agonists (cabergoline), and statins (simvastatin). However, no randomized controlled trials have evaluated the efficacy of these drugs. In conclusion, this review summarizes the following 2 points: superoxide anion generation by methemoglobin is enhanced in endometriosis, resulting in redox imbalance; and some compounds and natural substances that can suppress free radicals may be effective in endometriosis-related pain. Further randomized clinical trials based on larger series are mandatory to confirm the promising role of antioxidants in the nonhormonal management of endometriosis.

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Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review

Hipólito-Reis

Neto

Neves

2022

Phytotherapy Research

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Endometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self-controlled interventions including dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin, and resveratrol can act as natural interventions to control endometriosis. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A comprehensive search was carried out in PubMed, Scopus, and Web of Science to gather together all the articles that study the specific actions of curcumin, resveratrol, or quercetin in endometriosis pathophysiology. All types of study designs including experimental data were considered. Thirty articles, including a clinical trial, were included. For the assessment of the quality of the selected studies that globally have "good quality", the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used. By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis, angiogenesis and glucose and lipid metabolism, curcumin, quercetin, and resveratrol showed to have beneficial effects, evidencing their potential application in the endometriosis treatment. However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.

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The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial

Cited by 34 publications

References 44 publications

MTA1, a Target of Resveratrol, Promotes Epithelial-Mesenchymal Transition of Endometriosis via ZEB2

MTA1, a Target of Resveratrol, Promotes Epithelial-Mesenchymal Transition of Endometriosis via ZEB2

Nonhormonal Treatment for Endometriosis Focusing on Redox Imbalance

Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review

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