2019
DOI: 10.1016/j.fsi.2018.10.035
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The modulation of Smac/DIABLO on mitochondrial apoptosis induced by LPS in Crassostrea gigas

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Cited by 18 publications
(12 citation statements)
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“…Mitochondria are the main sites of ATP production that are required for cellular energy metabolism. Studies have demonstrated that LPS-induced inflammatory responses can cause severe damage to the structure and function of mitochondria [36,37]. In the current study, we evaluated HUVECs for mitochondrial ROS generation levels and mitochondrial membrane potential (MMP).…”
Section: Pue Regulated Huvec Mqc Under Lps-inducedmentioning
confidence: 99%
“…Mitochondria are the main sites of ATP production that are required for cellular energy metabolism. Studies have demonstrated that LPS-induced inflammatory responses can cause severe damage to the structure and function of mitochondria [36,37]. In the current study, we evaluated HUVECs for mitochondrial ROS generation levels and mitochondrial membrane potential (MMP).…”
Section: Pue Regulated Huvec Mqc Under Lps-inducedmentioning
confidence: 99%
“… 42 , 43 LPS has been reported to be able to activate the p -JNK 44 and NF-κB 45 signaling pathways and to be related to the multiple immune response processes, such as inflammation 45 and apoptosis. 46 In this study, the CgFFAR4 level significantly decreased after the LPS injection versus the phosphate-buffered saline injection, indicating that CgFFAR4 is involved in the anti-immune response of Pacific oysters. In human or mouse cells, FFAR4 expression markedly decreases upon LPS challenge 14 and inhibits LPS-stimulated cytokine expression.…”
Section: Discussionsupporting
confidence: 48%
“…Apoptosis is indeed a common response to microbial elicitation as a mechanism to maintain tissue homeostasis and to restrain infection spread ( 75 , 76 ). Genes like caspases and ubiquitin ligases, which trigger and regulate apoptosis ( 77 79 ), are often activated by LPS in different animal groups like in C. elegans ( 80 ) and mollusks ( 81 , 82 ). Apoptosis emerges as a common response to bacterial elicitors in sponges ( 25 , 26 , this study), as well as in cnidarians ( 83 , 84 ) and mollusks ( 81 , 82 ).…”
Section: Discussionmentioning
confidence: 99%