The modulatory effects of ellagic acid and vitamin E succinate on TCDD‐induced oxidative stress in different brain regions of rats after subchronic exposure

Hassoun, Ezdihar A.; Vodhanel, Jennifer; Abushaban, Ahmed

doi:10.1002/jbt.20030

Cited by 81 publications

(39 citation statements)

References 52 publications

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“…Along with the reduction in GSH content, activities of various enzymic antioxidants such as SOD, CAT, GST and GPx were also found to be significantly decreased during TCDD treatment. These results are in line with the earlier reports where TCDDinduced oxidative stress is mediated through an imbalance in antioxidant status (Stohs 1990;Hassoun et al 2004;Jin et al 2008). From the results it is evident that oxidative stress acts as a major contributor in the TCDD-induced nephrotoxic effects.…”

Section: Discussionsupporting

confidence: 92%

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Palaniswamy

Vishwanadha

Singaravelu

2014

Cell Stress and Chaperones

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Humans are systemically exposed to persistent organic pollutants, of which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has become a major environmental concern. Exposure to TCDD results in a wide variety of adverse health effects which is mediated by oxidative stress through CYP1A1 activation and arachidonic acid metabolites. Eicosapentaenoic acid (EPA) exhibits antioxidant property and competes with arachidonic acid in membrane phospholipids and produces anti-inflammatory EPA derivatives. Since both EPA and its derivatives have been reported to enhance the antioxidant mechanism, the present study aimed at studying whether EPA could offer protection against TCDDinduced oxidative stress and nephrotoxicity in Wistar rats. Estimation of kidney markers (serum urea and creatinine) and histopathological studies revealed that EPA treatment significantly reduced TCDD-induced renal damage. TCDDinduced oxidative damage was reflected in a significant increase in CYP1A1 activity and lipid peroxide levels with a concomitant decline in non-enzymic antioxidant (GSH) and various enzymic antioxidants such catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), and glutathione peroxidase (GPx). In addition, TCDD-induced oxidative stress also resulted in decline in Na + -K + and Mg 2+ATPases activities with increase in Ca 2+ ATPases activity. Oral treatment with EPA showed a significant cytoprotection against TCDD-induced renal oxidative stress by decreased CYP1A1 activity and enhanced antioxidant status. TCDD-induced alterations in ATPase enzyme activities were also prevented by EPA treatment. Our results show clear evidence that EPA ameliorates TCDD-induced oxidative stress and kidney damage; thus suggest the potential of EPA as an effective therapeutic agent against toxic effects mediated through redox imbalance.

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Section: Discussionsupporting

confidence: 92%

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Palaniswamy

Vishwanadha

Singaravelu

2014

Cell Stress and Chaperones

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“…Over the last few years, a number of in vivo and in vitro studies have provided evidence of important pharmacological properties including antioxidant, anti-inflammatory [7,8,9,10,11] and anticarcinogenic activities [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Rosillo

Sánchéz-Hidalgo

Cárdeno

et al. 2011

Biochemical Pharmacology

153

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 37A c c e p t e d M a n u s c r i p t

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“…They exert many health-promoting effects (7), including antioxidant activity (8) or the inhibition of the growth of cancer cells in culture (9). Ellagic acid (ELA) is a phenolic compound presenting a variety of biological activities including potent antioxidant (10), anticancer (11), and antimutagen (12) properties. Resveratrol, a naturally occurring phytoalexin, associated with many health benefits, most notably the mitigation of age-related diseases, including neurodegeneration, carcinogenesis, and atherosclerosis (13,14).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Combined Phytochemicals and Skin Cancer Prevention in SENCAR Mice

Kowalczyk

Tolstykh

et al. 2010

Cancer Prevention Research

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The purpose of our study was to determine the inhibitory effect of combined phytochemicals on chemically induced murine skin tumorigenesis. Our hypothesis was that concurrent topical and dietary treatment with selected compounds would lead to more efficient prevention of skin cancer. We tested ellagic acid and calcium D-glucarate as components of diets, while resveratrol was applied topically; grape seed extract was applied topically or in the diet. The 4-week inflammatory-hyperplasia assay based on the 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin carcinogenesis model in SENCAR mice was used. We have found that all the selected combinations caused a marked decrease of epidermal thickness compared with the DMBA-treated group and also with groups treated with a single compound and DMBA. All combinations of resveratrol with other compounds showed a synergistic effect on hyperplasia and Ha-ras mutations. Skin tissue of mice receiving the combinations showed decreased cell proliferation and Bcl2 expression; decreased p21, a regulator of cell cycle; and decreased marker of inflammation cyclooxygenase-2. All the selected combinations diminished the DMBA-induced mRNA expression of the CYP1B1 level, and also caused a marked decrease of proto-oncogenes c-jun and c-fos, components of transcription factor activator protein. In conclusion, all combinations showed either additive or synergistic effects and their joint actions allowed for decreasing the doses of the compounds. Especially, resveratrol combinations with ellagic acid, grape seed extract, and other phytochemicals are very potent inhibitors of skin tumorgenesis, based on the suppression of epidermal hyperplasia as well as on the modulation of intermediate biomarkers of cell proliferation, cell survival, inflammation, oncogene mutation, and apoptosis.Cancer Prev Res; 3(2); 170-8. ©2010 AACR.

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The modulatory effects of ellagic acid and vitamin E succinate on TCDD‐induced oxidative stress in different brain regions of rats after subchronic exposure

Cited by 81 publications

References 52 publications

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Protective effect of ellagic acid, a natural polyphenolic compound, in a murine model of Crohn's disease

Synergistic Effects of Combined Phytochemicals and Skin Cancer Prevention in SENCAR Mice

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