The Molecular Alterations Regarding Apoptosis in Hepatocellular Carcinoma Cells at a Glance

Yuan, Yi; Zhang, Yu Sheng; Qu, Xian‐Jun

doi:10.4172/2157-2518.1000118

Cited by 7 publications

(6 citation statements)

References 70 publications

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“…Many HCC cells also show to be less sensitive to apoptotic signals induced by death receptor ligands. 11 Recently focus has been directed towards molecular targeting of herbal compounds to identify the mechanism(s) of action of these newly discovered bioactive compounds. Herbal medicine has become a popular complementary and alternative strategy for cancer; doubts concerning interference with the action of conventional chemotherapeutic drugs have been raised recently.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis and Growth Suppressing Activity of Sapindus saponaria L. Pericarp Extract on Hepatocellular Carcinoma Cells

Roy¹,

Kumar²,

Besra³

2020

IJPSRR

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Sapindus saponaria L. has revealed a number of properties of this plant which includes antioxidant, hepatoprotective, antiinflammatory, anti-cancer, anxiolytic, fungicidal, spermicidal activity. The present study investigated the anti-cancer activity of Sapindus saponaria L. pericarp extract (SSFE) on hepato carcinoma cell lines. The extract and fractions significantly inhibited cell the viability in a time and concentration dependent manner in both the carcinoma cells. Morphological study showed several signs of apoptosis like chromatin condensation, nuclear fragmentation and formation of apoptotic bodies and degraded DNA bands in both the treated hepatoma cells than control. Treated cells exerted significant MMP shift in the mitochondrial transmembrane potential activity involving the release of cytochrome c into the cytosol. The cell cycle phase arrest was observed in the G0/G1 phase change in the EFESS treated cells. These findings suggest that extracts possess cytotoxic and apoptosis activity against both the hepatocellular carcinoma cells. Further mechanistic studies are under process to determine the different pathways attributing to apoptosis.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis and Growth Suppressing Activity of Sapindus saponaria L. Pericarp Extract on Hepatocellular Carcinoma Cells

Roy¹,

Kumar²,

Besra³

2020

IJPSRR

View full text Add to dashboard Cite

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“…Molecular Alterations Regarding Apoptosis in Hepatocellular Carcinoma Cells at a Glance: hepatocellular carcinoma (HCC) has been a grievous scourge of humanity for a long time. The current related articles and provide a further understanding about such molecular changes relevant to trigger imbalances in the regulation of apoptosis in HCC [23].…”

Section: Thementioning

confidence: 99%

Biomarkers and their Role in Premonition, Interpretation and Treatment of Cancer

YRKM¹,

Dattatreya²,

SY³

et al. 2011

J Cancer Sci Ther

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The Prognosis and Diagnosis of CANCER has become easier now days, in earlier days, there has been a degree of difficulty in the premonition and Interpretation of the disease, either of the carcinomas, sarcomas, lymphomas and/ or etc cancers types are very dreadful diseases which do not have methods of earlier detections. Biomarkers' are the astounding promise for both of the Diagnosis and Prognosis of the cancer. They set a future for the further eagle eye study of various cancers. In this review it will be stating various types of biomarkers whether they are immunological origin or of molecular origin. In the finale statement is we tried to summarize and hypothesize the types in the biomarkers' for the prognosis and diagnosis of Cancer.

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“…It helps in growth and function of cell.BRAC1 which is normally regulated by protein turnover is stabilized by BARD1 which recruits BRCA1 to nucleus to form ubiquitin E3 ligase complex which is involved in DNA repair. BARD1 regulates BRCA1 depended apoptosis by a mechanism involving nuclear sequestration [59,60]. Regulation of apoptosis by BARD1 was reduced by BRCA1 cancer mutations that disrupt Ub ligase function [61].…”

Section: Bard1mentioning

confidence: 99%

Epidemiology of Genetic Alterations in Progression of Breast Cancer

P¹

2012

J Carcinogene Mutagene

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Breast cancer is the most frequent cancer in women responsible for almost 20% of all cancer deaths. Certain aberrations in the genes results higher risk in the development of breast cancer. The present review aims to consolidate a comprehensive role of different genes involved in the development of breast cancer. This helps to know the intracellular molecular changes in tumorigenic pathways within the mammary gland.

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The Molecular Alterations Regarding Apoptosis in Hepatocellular Carcinoma Cells at a Glance

Cited by 7 publications

References 70 publications

Phytochemical Analysis and Growth Suppressing Activity of Sapindus saponaria L. Pericarp Extract on Hepatocellular Carcinoma Cells

Phytochemical Analysis and Growth Suppressing Activity of Sapindus saponaria L. Pericarp Extract on Hepatocellular Carcinoma Cells

Biomarkers and their Role in Premonition, Interpretation and Treatment of Cancer

Epidemiology of Genetic Alterations in Progression of Breast Cancer

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