The molecular and genetic aspects of adolescent girls anomalous uterine bleeding: the role of endothelial dysfunction syndrome

Abstract

The objective of the study is to assess NOS3 and ESR1 gene polymorphism in adolescent girls born with low birth weight (LBW) and suffered by anomalous uterine bleeding (AUB). A total 95 adolescent girls were studied including 32 born with LBW and AUB; 36 girls with normal birth weight and AUB; and 27 healthy girls. Single allele gene polymorphism NOS3 786T4C, 894G4T, ESR1 351A4G and 397T4C was studied. The existence of polymorphous allele Q gene NOS3 786R4Q (for homozygote OR ¼ 2.03; 95% CI: 1.12-3.68; p ¼ 0.04; for heterozygote OR ¼ 1.68; 95% CI: 1.09-2.60; p ¼ 0.046) and genotype Pvull-CC ESR1 (OR ¼ 4.58; 95% CI: 0.97-21.68; p ¼ 0.04) was detected in LBW girls with AUB. It was suggested that intrauterine programming of endothelial dysfunction syndrome could play a significant role in the development of AUB in adolescent girls born with LBW.