The Molecular Bases Study of the Inherited Diseases for the Health Maintenance of the Beef Cattle

Abstract

The article highlighted the problem of meat cattle genetic defects. The aim was the development of DNA tests for some genetic defects diagnostics, the determination of the animal carriers and their frequencies tracking in time. The 1490 DNA samples from the Aberdeen Angus (n = 701), Hereford (n = 385), Simmental (n = 286) and Belgian Blue (n = 118) cattle have been genotyped on the genetic defects by newly created and earlier developed DNA tests based on AS-PCR and PCR-RFLP methods. The Aberdeen Angus cattle genotyping has revealed 2.38 ± 0.31% AMC-cows and 1.67 ± 0.19 % AMC-bulls, 0.65 ± 0.07% DDC-cows and 0.90 ± 0.10% DDC-bulls. The single animals among the Hereford cattle were carriers of MSUD and CWH (on 0.27 ± 0.05%), ICM and HY (on 0.16 ± 0.03%). The Simmental cattle were free from OS. All Belgian Blue livestock were M1- and 0.84%-CMD1-carriers. The different ages Aberdeen Angus cattle genotyping has shown the tendency of the AMC- and DDC frequencies to increase in the later generations. The statistically significant increase of DDC of 1.17% in the cows’ population born in 2019 compared to those born in 2015 allows concluding the further development of the DNA analysis-based measures preventing the manifestation of the genetic anomalies in meat cattle herds is necessary.

Genetic Variations and Haplotypic Diversity in the Myostatin Gene of Different Cattle Breeds in Russia

“…Previous investigations of nt821(del11) MSTN in Belgian Blue cattle have shown that all heads of this breed were carriers of the mutant allele associated with double-muscling [25]. The additional nt821(del11) MSTN genotyping conducted in the frame of the current work has confirmed the earlier obtained data and conclusion of our colleagues overseas, that the mutant allele associated with the double-muscling genetic defect was fixed in the Belgian Blue cattle breed due the long-time selection in regard to increased muscle mass [26].…”

Associations between polymorphisms in the myostatin gene with calving difficulty and carcass merit in cattle

“…While the nt821 deletion is almost fixed in the Belgian Blue population ( Smith et al, 2000 ; Konovalova et al, 2021a ), it has been introduced in other breeds at a low frequency ( Gill et al, 2009 ; Konovalova et al, 2021b ). Because the haplotype with the nt821 deletion and the nt374_51 mutation was detected at a low frequency in the Angus population but was common in the Belgian Blue population, it is likely that the nt821 deletion was introduced into the Angus population through crossbreeding prior to 2003; the oldest Angus animal in the present study with that haplotype was born in 2003.…”