The molecular basis of neurotrophic keratopathy: Diagnostic and therapeutic implications. A review

Ruiz-Lozano, Raúl E.; Hernández-Camarena, Julio C.; Loya-García, Denise; Merayo‐Lloves, Jesús; Rodríguez-García, Alejandro

doi:10.1016/j.jtos.2020.09.007

Cited by 42 publications

(54 citation statements)

References 152 publications

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“…The higher divergence between the two groups in terms of long-term outcomes and response to recurrence treatment compared to corneal healing immediately post-treatment can potentially be attributed to the difference in the mechanism of each treatment. Specifically, the lower recurrence rate in the cenegermin-treated group suggests that this drug induces corneal recovery by restoring sensory nerve supply, according to previous studies [6,7,24,25,[27][28][29]. Our results also showed that visual acuity significantly improved after 12 months of follow-up in cenegermin group when compared with baseline values, but not in AMT group.…”

Section: Discussionsupporting

confidence: 83%

“…As consequence, cenegermin, even if it is the only approved drug for NK treatment, shows a limited clinical use, and several surgical approaches, such as tarsorrhaphy, sutured and sutureless AMT, or conjunctival flap as well as medical treatments such as blood-derived eye drops including autologous serum, umbilical serum, and PRP, still remain the only treatment choices for NK patients in many parts of the world [2,14,22]. Currently, the use of blood-derived eye drops is still limited by the difficulty to establish an optimal concentration and dose regimen as well as by risk of contamination and limited accessibility [13,29,30].…”

Section: Discussionmentioning

confidence: 99%

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Long-term clinical outcome and satisfaction survey in patients with neurotrophic keratopathy after treatment with cenegermin eye drops or amniotic membrane transplantation

Sacchetti

Komaiha

Albanese

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. The purpose of this study is to evaluate the clinical outcomes and patient-reported satisfaction of treatment with amniotic membrane transplantation (AMT) or cenegermin eye drops in patients with NK. Methods Clinical charts of patients with NK treated with AMT (group A) or cenegermin eye drops (group B), with at least 12 months of follow-up, were reviewed for demographics, medical history, corneal healing, and disease recurrence. Patient satisfaction was evaluated by a newly developed questionnaire investigating patient’s appreciation of treatment of NK (2 items) and satisfaction with NK treatment outcomes (5 items). Results At the end of treatment, complete corneal healing was observed in 13/15 (86%) patients in group A and in 23/24 (96%) in group B. At 12 months follow-up, 6/13 patients (46%) in group A and 3/23 patients (13%) in group B showed recurrence of NK (p = 0.037). Survival analysis showed that group B remained recurrence free for a significantly longer period of time than the group A (p = 0.028). Patients in group B showed a significantly higher satisfaction when compared with patients in group A (total score: 65.7 ± 15.7 vs 47.4 ± 12.8, p = 0.003), both in terms of patients’ appreciation of treatment (78.3 ± 15.9 vs 52.2 ± 30, p = 0.020) and satisfaction with treatment outcomes (60.7 ± 21 vs 45.4 ± 13.3, p = 0.037). Conclusions Treatment of NK with cenegermin was associated with long-term maintenance of corneal integrity and a higher degree of patient satisfaction.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Long-term clinical outcome and satisfaction survey in patients with neurotrophic keratopathy after treatment with cenegermin eye drops or amniotic membrane transplantation

Sacchetti

Komaiha

Albanese

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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“…Corneal scarring may occur after a myriad of causes, including herpetic keratitis, corneal trauma, previous corneal infections, chemical and thermal burns, NK, corneal hydrops (Figures 3A, B), cicatrizing keratoconjunctivitis, and autoimmune corneal ulceration [27][28][29]. Scarring results in a reduced quality of vision because of leukoma formation, high-order aberrations, and irregular astigmatism.…”

Section: Abbreviationsmentioning

confidence: 99%

Update on indications, complications, and outcomes of scleral contact lenses

Ruiz-Lozano¹,

Gomez-Elizondo²,

Colorado-Zavala³

et al. 2022

Med Hypothesis Discov Innov Ophthalmol

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Background: The role of scleral contact lenses (SCLs) has increasingly expanded since the first lens was fitted more than a century ago. While it was initially prescribed for the management of severely compromised corneas, the indications for modern SCL use have expanded to include less severe diseases. In this review, we aimed to provide an up-to-date overview of the current indications, complications, and outcomes for the various types of SCLs. Methods: In this narrative review, we thoroughly searched the PubMed/MEDLINE database for literature published from January 1980 to November 2021. Only relevant up-to-date English references were included. Furthermore, the figures in this manuscript were derived from our unit’s patient documentation. Results: Currently, SCLs can successfully be used to manage ocular surface diseases, visually rehabilitate irregular corneas, and correct irregular refractive errors. Although newer materials have yielded the same visual outcomes with fewer complications, these consequences still occur in approximately one-third of contact lens wearers, including difficulties in insertion and/or removal, discomfort or pain, and developing either halos, blurriness, or haze. Even though most of these complications are minor and can be easily treated, a good practice is essential to avoid sight-threatening complications such as microbial keratitis. Conclusions: SCLs are indispensable in ophthalmic clinics. The development of better-quality SCLs has increased the number of indications and improved the achievable visual rehabilitation. The future of developing improvements in SCL design, materials, and fit, and the expansion of their indication range is promising.

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“…IVCM is a non-invasive imaging technique that allows dissection of the corneal architecture at a cellular level, providing real-time images equivalent to those obtained from ex-vivo histopathological techniques (tissue biopsy) [108]. It is currently used to evaluate corneal nerves in healthy eyes and those affected by ectatic corneal diseases, neurotrophic keratopathy, corneal dystrophies, ocular surface inflammation, contact lens wear, and infectious keratitis [108][109][110].…”

Section: In Vivo Confocal Microscopy (Ivcm)mentioning

confidence: 99%

Contact Lens-Associated Infectious Keratitis: Update on Diagnosis and Therapy

Alamillo-Velazquez¹,

Ruiz-Lozano²,

Hernández-Camarena³

et al. 2021

Infectious Eye Diseases - Recent Advances in Diagnosis and Treatment

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The focus of this chapter is to review the most recent advances in the diagnosis and treatment of contact-lens-related infectious keratitis, the most sight-threatening complication of contact lens wear. In the last decades, contact lenses technology has confronted several challenges, including the need for safer and more comfortable polymer materials. The development of high coefficient oxygen permeability (Dkt) and low-water content disposable contact lens translated into a significant improvement in ocular discomfort related to dry eye and allergic reactions, decreasing biofilm build-up on the external surface of the lens. Additionally, the emergence and boom-effect of corneal refractive surgery have also driven the development of better contact lens manufacturing. Despite these substantial technological advances, contact lens users continue to be at risk for developing corneal infections. We describe recent epidemiologic data, and advances in understanding the complex pathogenesis of the disease, including the clinical characteristics of the infectious process produced by bacteria, fungi, and protozoans. Finally, the recent development of diagnostic techniques and therapeutic regimens are discussed.

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The molecular basis of neurotrophic keratopathy: Diagnostic and therapeutic implications. A review

Cited by 42 publications

References 152 publications

Long-term clinical outcome and satisfaction survey in patients with neurotrophic keratopathy after treatment with cenegermin eye drops or amniotic membrane transplantation

Long-term clinical outcome and satisfaction survey in patients with neurotrophic keratopathy after treatment with cenegermin eye drops or amniotic membrane transplantation

Update on indications, complications, and outcomes of scleral contact lenses

Contact Lens-Associated Infectious Keratitis: Update on Diagnosis and Therapy

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