The Molecular Connection Between Aluminum Toxicity, Anemia, Inflammation and Obesity: Therapeutic Cues

Bignucolo, Adam; Lemire, Joseph; Auger, Christopher; Castonguay, Zachary; Appanna, Varun P.; Appanna, Vasu D.

doi:10.5772/30273

Cited by 10 publications

(5 citation statements)

References 40 publications

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“…Exposure to neurotoxicants such as Al has been shown to impair the activities of these antioxidant enzymes and thus, compromise cellular defense against oxidative stress. One of the hypothesized mechanisms behind Al‐mediated oxidative stress is its ability to increase free iron level by displacing iron from iron containing proteins and thus propagates iron‐induced oxidative stress (Bayliak et al, 2019; Bignucolo et al, 2012; Wu et al, 2012). Interestingly, in this present study, both AE and BN extracts chelated Fe 2+ in dose‐dependent manner; an observation that agrees with earlier reports (Famuwagun et al, 2017; Jeong et al, 2010; Sudhanshu & Ekta, 2012).…”

Section: Discussionmentioning

confidence: 99%

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

et al. 2020

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The pathogenesis of several neurodegenerative diseases have been identified to be both genetic and sporadic; considering the latter, environmental risk factors are very prominent. One of the most ubiquitous element in the environment is aluminum (Al), valuable for producing various domestic and industrial products for human uses (Bayliak et al., 2019; Liu et al., 2018). Physiologically, Al is a nonessential metal and excessive exposure to it has been

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Section: Discussionmentioning

confidence: 99%

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

et al. 2020

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“…Aluminum is a trivalent metal like Fe and binds with transferrin in the blood, which is one of its main mechanisms of toxicity. Al can replace Fe, and this free form of Fe can then cause oxidative stress [ 4 40 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress

et al. 2016

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Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer's disease. In this study, we investigated the effects of Al and/or D-galactose on neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons in the hippocampal dentate gyrus. AlCl3 (40 mg/kg/day) was intraperitoneally administered to C57BL/6J mice for 4 weeks. In addition, vehicle (physiological saline) or D-galactose (100 mg/kg) was subcutaneously injected to these mice immediately after AlCl3 treatment. Neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons were detected using the relevant marker for each cell type, including nestin, Ki67, doublecortin, and NeuN, respectively, via immunohistochemistry. Subchronic (4 weeks) exposure to Al in mice reduced neural stem cells, proliferating cells, and differentiating neuroblasts without causing any changes to mature neurons. This Al-induced reduction effect was exacerbated in D-galactose-treated mice compared to vehicle-treated adult mice. Moreover, exposure to Al enhanced lipid peroxidation in the hippocampus and expression of antioxidants such as Cu, Zn- and Mn-superoxide dismutase in D-galactose-treated mice. These results suggest that Al accelerates the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in D-galactose-treated mice via oxidative stress, without inducing loss in mature neurons.

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“…Additionally, Al toxicity leads to an increase in very low-density lipoprotein secretion and a decrease in β-oxidation of fatty acids [69]. This fact is directly linked to the accumulation of fatty tissue seen in obesity [70].…”

Section: Discussionmentioning

confidence: 99%

Blood Concentration of Macro- and Microelements in Women Who Are Overweight/Obesity and Their Associations with Serum Biochemistry

Knazicka,

Bihari,

Janco

et al. 2024

Life

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Risk elements in blood matrices can affect human health status through associations with biomarkers at multiple levels. The aim of this study was to analyze 15 macro- and microelements in the blood serum of women with overweight (BMI of ≥25 kg/m2) and obesity (BMI of ≥30 kg/m2) and to examine possible associations with biochemical, liver enzymatic parameters, and markers of oxidative stress. Based on the power calculation, the study involved women (in the postmenopausal stage) whom are overweight (n = 26) and obese (n = 22), aged between 50–65 years. Multifrequency bioelectrical impedance analysis was used to measure body composition parameters. Concentrations of elements were determined by inductively coupled plasma optical emission spectrometry, and Hg was measured using cold-vapor atomic absorption spectroscopy. Individuals with obesity, as indicated by a higher BMI, percentage of body fat, and visceral fat area, had elevated serum levels of Ca, Mg, Fe, Al, Sr, Pb, and Hg. Concentrations of Al, Cu, K, Sb, Zn, and Pb significantly affected biochemical and liver function markers in women who were overweight or obese. Elements such as Cu and Al were associated with increased total cholesterol. The correlation analysis between total antioxidant status and Cu, Al, and Ni confirmed associations in both groups. Our findings underscore the importance of addressing excess body weight and obesity in relation to risk elements. The results of the research could be beneficial in identifying potential targets for the treatment or prevention of comorbidities in people with obesity.

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The Molecular Connection Between Aluminum Toxicity, Anemia, Inflammation and Obesity: Therapeutic Cues

Cited by 10 publications

References 40 publications

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

Solanum vegetable‐based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress

Blood Concentration of Macro- and Microelements in Women Who Are Overweight/Obesity and Their Associations with Serum Biochemistry

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