The molecular genetic basis of fetal granulosa cell development

Greenfield, Andy

doi:10.1016/j.coemr.2020.11.010

Cited by 5 publications

(4 citation statements)

References 55 publications

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“…Molecular mechanisms of gonadal sex determination and differentiation have been thoroughly reviewed by other authors [Kashimada and Koopman, 2010;Eggers et al, 2014;She and Yang, 2014;Greenfield, 2021]. In brief, the primary male-determining Sry gene is expressed from the Y chromosome in the XY gonadal primordium and upregulates its target Sox9 on the mouse chromosome 11.…”

Section: Xy Sex-reversed Femalesmentioning

confidence: 99%

Role of the X and Y Chromosomes in the Female Germ Cell Line Development in the Mouse (Mus musculus)

Yamazaki

Tan

Taketo

2022

Sex Dev

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Background: In eutherian mammals, the sex chromosome complement, XX and XY, determines sexual differentiation of gonadal primordia into testes and ovaries, which in turn direct differentiation of germ cells into haploid sperm and oocytes, respectively. When gonadal sex is reversed, however, the germ cell sex becomes discordant with the chromosomal sex. XY females in humans are infertile, while XY females in the mouse (Mus musculus) are subfertile or infertile dependent on the cause of sex reversal and the genetic background. This article reviews publications to understand how the sex chromosome complement affects the fertility of XY oocytes by comparing with XX and monosomy X (XO) oocytes. Summary: The results highlight 2 folds disadvantage of XY oocytes over XX oocytes: (1) the X and Y chromosomes fail to pair during the meiotic prophase I, resulting in sex chromosome aneuploidy at the first meiotic division and (2) expression of the Y-linked genes during oocyte growth affects the transcriptome landscape and renders the ooplasmic component incompetent for embryonic development. Key Message: The XX chromosome complement gives the oocyte the highest competence for embryonic development.

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Section: Xy Sex-reversed Femalesmentioning

confidence: 99%

Role of the X and Y Chromosomes in the Female Germ Cell Line Development in the Mouse (Mus musculus)

Yamazaki

Tan

Taketo

2022

Sex Dev

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“…Once specified, Sertoli and pre-granulosa cells instruct other somatic progenitors and the primordial germ cell to commit and differentiate toward the testicular or ovarian cell fates. In XX gonads, the canonical Wnt pathway (WNT4/RSPO1/β-catenin) and the transcription factors (TFs), FOXL2 and RUNX1, induce the differentiation of pregranulosa cells (Greenfield, 2021). In XY gonads, sex determination is governed by the Sry gene located on the Y chromosome (Sinclair et al, 1990;Koopman et al, 1991) that activates the expression of the transcription factor SOX9 at E11.5 (Gonen et al, 2018), which in turn controls the differentiation of Sertoli cells (Vining et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development

Stévant,

Gonen,

Poulat

2024

Front. Cell Dev. Biol.

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Gonadal sex determination in mice is a complex and dynamic process, which is crucial for the development of functional reproductive organs. The expression of genes involved in this process is regulated by a variety of genetic and epigenetic mechanisms. Recently, there has been increasing evidence that transposable elements (TEs), which are a class of mobile genetic elements, play a significant role in regulating gene expression during embryogenesis and organ development. In this study, we aimed to investigate the involvement of TEs in the regulation of gene expression during mouse embryonic gonadal development. Through bioinformatics analysis, we aimed to identify and characterize specific TEs that operate as regulatory elements for sex-specific genes, as well as their potential mechanisms of regulation. We identified TE loci expressed in a time- and sex-specific manner along fetal gonad development that correlate positively and negatively with nearby gene expression, suggesting that their expression is integrated to the gonadal regulatory network. Moreover, chromatin accessibility and histone post-transcriptional modification analyses in differentiating supporting cells revealed that TEs are acquiring a sex-specific signature for promoter-, enhancer-, and silencer-like elements, with some of them being proximal to critical sex-determining genes. Altogether, our study introduces TEs as the new potential players in the gene regulatory network that controls gonadal development in mammals.

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“…Also, GCs with theca cells are the main steroidogenic cells of the ovary. The development of follicles in the ovaries begins with the proliferation of GCs, which change their shape from flat to cubic and from a single layer to a multilayer, depending on the follicular phase [3][4][5] . The aim of the present document was to perform a narrative review, focusing on the role of GCs in follicle maturation and oocyte quality, as well as in the molecular mechanisms involved in this process.…”

Section: Introductionmentioning

confidence: 99%

Granulosa cells and follicular development: a brief review

Cavalcanti,

Carvalho,

Ferreira

et al. 2023

Rev. Assoc. Med. Bras.

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The molecular genetic basis of fetal granulosa cell development

Cited by 5 publications

References 55 publications

Role of the X and Y Chromosomes in the Female Germ Cell Line Development in the Mouse (Mus musculus)

Role of the X and Y Chromosomes in the Female Germ Cell Line Development in the Mouse (Mus musculus)

Transposable elements acquire time- and sex-specific transcriptional and epigenetic signatures along mouse fetal gonad development

Granulosa cells and follicular development: a brief review

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