The Molecular Mechanisms of the effect of anticancer activity on lichen metabolites

Şekerli, Merve; Kılıç, Nil; Cansaran-Duman, Demet

doi:10.5505/turkhijyen.2016.24650

Cited by 4 publications

(2 citation statements)

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“…In recent studies, it has been shown that the number of lichens reaches 1000 and many metabolites that are specific to lichens are synthesized by these lichen species (Özenoğlu et al, 2013). In the literature, these lichen metabolites have been reported with their antibiotics, antimycotic, antiviral, anti-inflammatory, analgesic, antipyretic, antiproliferative and cytotoxic effects (Rankovic et al 2007;Şekerli et al, 2017). Studies in our country on antimicrobial activities of lichens are quite insufficient.…”

Section: Introductionmentioning

confidence: 99%

Investigate the Antibacterial Activity of Lichen Biomass Used in Textile Dye Removal

Gül¹

2020

JBLS

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All over the world, the treatment of textile wastewater has become a significant problem due to the development of the textile industry. Particularly, the treatment of synthetic dyes, which are found abundantly amounts in textile wastewater, has gained importance. Recent studies have focused on the use of biological treatment technologies to remove pollutants in water. On the other hand, the disposal of wastes from biological treatment technologies was considered as another environmental problem. This study aims to compare the antimicrobial properties of the extract obtained from dye loaded and un-loaded lichen biomass after the biosorption process. According to the results of this study, it was found that the extract obtained from the waste lichen biomass, which has loaded with the textile dye in the decolorization process, showed a similar antimicrobial effect with the unloaded lichen extract. To sum up the waste lichen biomass used to remove textile dyes can be reused for the application of antimicrobial products.

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Section: Introductionmentioning

confidence: 99%

Investigate the Antibacterial Activity of Lichen Biomass Used in Textile Dye Removal

Gül¹

2020

JBLS

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“…[10][11][12][13][14][15][16] As a result of these studies, lichen secondary metabolites may provide important results related withits use as candidate drug molecules. Usnic acid and its enantiomers are the most extensively studied lichen secondary metabolites.…”

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Evaluation of in vitro Anticancer Activity of Vulpinic Acid and its Apoptotic Potential Using Gene Expression and Protein Analysis

Kılıç¹,

Derici²,

Büyük³

et al. 2018

IJPER

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Lichens and their secondary metabolite are still among the many unexamined natural sources in the drug industry. This study was designed to evaluate the cytotoxic effects of vulpinic acid lichen secondary metabolite and 6. 25, 12.5, 25, 50, 100, 200 and 400 µM concentrations that treat cancer cell lines (CaCo2, HepG2, Hep2C, RD Wehi) and normal cells (Vero and L929) by MTT assay. The aim of this study was to determine the apoptotic effect of vulpinic acid on a molecular level. The determination of apoptotic molecular patterns of vulpinic acid was performed on western blot and quantitative realtime PCR (qRT-PCR) analysis. In our study, transcriptome changes on both gene and protein levels showed similar results. The determination of, mRNA levels of Bax, Bcl-2 and P53 genes were showed by qRT-PCR in cancer and normal cell lines. The results of the study showed that IC 50 value of vulpinic acid altered the mRNA levels of Bax, Bcl-2 and P53 genes in all examined cancer cells when compared to the untreated cells. When the mRNA levels of the examined genes were compared, it was observed that Bax gene showed more expression increase in all cell lines when compared to Bcl-2 and P53 genes. This is the first evaluation of the apoptotic effect of vulpinic acid secondary metabolite on mRNA levels. The current study highlights some points regarding vulpinic acid and its use for cancer treatment.

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Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways

Mohammadi

Bagheri

Badreldin

et al. 2022

Chemico-Biological Interactions

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The Molecular Mechanisms of the effect of anticancer activity on lichen metabolites

Abstract: The components obtained from natural products Makale Dili "Türkçe"/Article Language "Turkish"

Cited by 4 publications

References 0 publications

Investigate the Antibacterial Activity of Lichen Biomass Used in Textile Dye Removal

Investigate the Antibacterial Activity of Lichen Biomass Used in Textile Dye Removal

Evaluation of in vitro Anticancer Activity of Vulpinic Acid and its Apoptotic Potential Using Gene Expression and Protein Analysis

Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways

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