The molecular phenotypes of ureteral telocytes are layer-specific

Dobra, Mihai; Vrapciu, Alexandra Diana; Pop, F.; Petre, Nicoleta; Rusu, Mugurel Constantin

doi:10.1016/j.acthis.2017.11.003

Cited by 17 publications

(9 citation statements)

References 48 publications

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“…The immunoreactive signals were widely distributed throughout interstitial tissue around LC and blood vessels, as well as peritubular area at which TCs were located. A Similar distribution for CD34‐positive stromal cell was reported in normal human testicular tissue (Kuroda et al, ), turtle testis (Yang et al, ), human mammary gland stroma (Petre et al, ), and human ureter (Dobra et al, ). CD117 or c‐kit is one of the key markers for detection of mesenchymal cells as well as TCs in different organs such as; bovine uterine tube (Abd‐Elhafeez and Soliman, ), human testis (Hasirci et al, ; Rodriguez et al, ) human placenta (Suciu et al, ) , rat mesentery (Hinescu et al, ), and human gallbladder (Hinescu et al, ).…”

Section: Discussionsupporting

confidence: 72%

Localization of telocytes in rabbits testis: Histological and immunohistochemical approach

Awad

Ghanem

2018

Microscopy Res & Technique

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Telocyte (TC) is an interesting unique interstitial cell demonstrated in many human and animal tissues and organs. This study verified, for the first time, the pattern of TC distribution in the testicular tissue of New Zealand White rabbits using histological, immunohistochemical, and electron microscopic tools. Rabbit testicular tissue samples were obtained from three pairs of adult healthy New Zealand white rabbit by surgical procedures. The testicular tissues were stained with hematoxyline-eosin, Crossmon's trichrome and Periodic acid Schiff. The immunohistochemistry was performed using three different antibodies CD34, CD117, and vimentin.

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Section: Discussionsupporting

confidence: 72%

Localization of telocytes in rabbits testis: Histological and immunohistochemical approach

Awad

Ghanem

2018

Microscopy Res & Technique

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“…The presence of VEGF in the perialveolar region was verified in colocalization with CD34, which indicates the role of telocytes in angiogenesis in the mammary gland during postlactational involution, which has also been proposed for telocytes in skeletal muscle (Suciu et al, 2012) and for those in the lungs (Hussein & Mokhtar, 2018). In addition, it has been hypothesized that telocytes would be able to differentiate into smooth muscle cells (Bei et al, 2015) or even into fibroblasts or myofibroblasts (Díaz‐Flores et al, 2016) and that they would belong to a wide subset of CD34‐positive cells that have progenitor potential (Sidney et al, 2014), which may indicate that a portion of these cells could possibly act in tissue reorganization through differentiation into fibroblasts or smooth muscle cells; however, further studies are necessary to assess this potential.…”

Section: Discussionmentioning

confidence: 99%

Telocytes are associated with tissue remodeling and angiogenesis during the postlactational involution of the mammary gland in gerbils

Sanches

Leonel

Maldarine

et al. 2020

Cell Biology International

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The postlactational involution of the mammary gland is a complex process. It involves the collapse of the alveoli and the remodeling of the extracellular matrix, which in turn implies a complex set of interrelations between the epithelial, stromal, and extracellular matrix elements. The telocytes, a new type of CD34‐positive stromal cell that differs from fibroblasts in morphological terms and gene expression, were detected in the stroma of several tissues, including the mammary gland; however, their function remains elusive. The present study employed three‐dimensional reconstructions and immunohistochemical, ultrastructural, and immunofluorescence techniques in histological sections of the mammary gland of the Mongolian gerbil during lactation and postlactational involution to evaluate the presence of telocytes and to investigate a possible function for these cells. By means of immunofluorescence assays for CD34 and c‐kit, major markers of telocytes, and also through morphological and ultrastructural evidences, telocytes were observed to surround the mammary ducts and collapsing alveoli. It was also found that these cells are associated with matrix metalloproteinase 9, which indicates that telocytes can play a role in extracellular matrix digestion, as well as vascular endothelial growth factor, a factor that promotes angiogenesis. Together, these data indicate that telocytes are a distinct cell type in the mammary gland and, for the first time, show that these cells possibly play a role in tissue remodeling and angiogenesis during the postlactional involution of the mammary gland.

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“…In recent years, researchers have used focused ion beam scanning electron microscopy to investigate the 3D imaging of TCs in human dermis, and have revealed the existence of Tps with various conformations: (i) long, flattened irregular veils (ribbon-like segments) with knobs, corresponding to podoms, and (ii) tubular structures (podomers) with uneven calibre because of irregular dilations (knobs) -the podoms 10 . So far, TCs have been detected in many tissues and organs, including the heart 11,12 , lung 13,14 , skeletal muscle 15 , skin 16,17 , eye 18,19 , liver 20 , uterus 21 and urinary system 22,23 .…”

mentioning

confidence: 99%

Ultrastructural and immunohistochemical characteristics of telocytes in human scalp tissue

Wang

Xiao

Zhang

et al. 2020

Sci Rep

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This study was designed to characterize the location, morphology and ultrastructure of telocytes (TCs) in human scalp tissue. After obtaining approval for this study and informed consent from the patient, a scalp specimen was obtained. the distribution and morphology of tcs in human scalp tissue was assessed by immunohistochemical staining of CD34 and CD117/c-KIT, and the ultrastructure of TCs was investigated using transmission electron microscopy (TEM). Immunohistochemical staining of CD34 revealed that TCs were located in the connective tissue of human scalp, and were concentrated around hair follicles (HFs), blood vessels, sweat glands, sebaceous glands and adipose lobules. Immunohistochemical staining of CD117 revealed that TCs were mainly located in the dermis of human scalp, surrounding the HFs and sweat glands. Under TEM, TCs were seen and confirmed by their special morphological features. These cells were spindle-shaped, had small cell bodies and long thin processes, and surrounded stem cell clusters in the bulge region of HFs. These results demonstrate that TCs in human scalp were positive for CD34 and CD117, and their strategic positioning surrounding stem cells suggests their possible involvement in local regeneration, remodeling and homeostasis of the skin.

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The molecular phenotypes of ureteral telocytes are layer-specific

Cited by 17 publications

References 48 publications

Localization of telocytes in rabbits testis: Histological and immunohistochemical approach

Localization of telocytes in rabbits testis: Histological and immunohistochemical approach

Telocytes are associated with tissue remodeling and angiogenesis during the postlactational involution of the mammary gland in gerbils

Ultrastructural and immunohistochemical characteristics of telocytes in human scalp tissue

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