The Mongolian Gerbil as a Model for the Analysis of Peripheral and Central Age-Dependent Hearing Loss

Gleich, Otto; Strutz, Jürgen

doi:10.5772/33569

Cited by 7 publications

(3 citation statements)

References 78 publications

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“…The Mongolian gerbil is a well-established animal model for hearing research [ 33 ]. Since the range of audible frequency is more similar to that of humans than other rodents such as mice, rats, or guinea pigs [ 34 ], gerbils have been considered as a suitable model in hearing research including aminoglycoside toxicity [ 5 ]. Furthermore, the larger bulla and thin skull enable a surgical approach to the cochlea.…”

Section: Discussionmentioning

confidence: 99%

Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model

Lee

Chung

et al. 2018

BioMed Research International

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Hair cells in the cochlea can be damaged by various causes. Damaged hair cells can lead to additional destruction of parts of the auditory afferent pathway sequentially, which is called secondary degeneration. Recently, researches regarding cochlear implants have been actively carried out for clinical purposes; secondary degeneration in animals is a much more practical model for identifying the prognosis of cochlear implants. However, an appropriate model for this research is not established yet. Thus, we developed a secondary degeneration model using an ototoxic drug. 35 gerbils were separated into four different groups and kanamycin was applied via various approaches. ABR was measured several times after drug administration. SGCs were also counted to identify any secondary degeneration. The results showed that outer and inner HCs were damaged in all kanamycin-treated groups. Twelve weeks after kanamycin treatment, the round window membrane injection group showed severe subject differences in hair cells and SGC damage, whereas the gelfoam group showed consistent and severe damage in hair cells and SGCs. In this study, we successfully induced secondary degeneration in hair cells in a gerbil model. This model can be used for various purposes in the hearing research area either for treatment or for preservation.

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Section: Discussionmentioning

confidence: 99%

Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model

Lee

Chung

et al. 2018

BioMed Research International

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“…Tasks are detailed below and included detection of simple tones (15 or 40 kHz) in silence; and of deviant tones (variable duration) in a pure-frequency background (Embedded Tone: 10.5 or 40 kHz background tone, 5.6 or 35 kHz cue tone; Pitch Discrimination: 10.5 or 40.5 kHz tone ± 75 Hz or 8 kHz cue tone). Tone frequencies were determined based on low and high-frequency bounds of the mouse audiogram (~2-50 KHz) 77 . Testing began at postnatal (P) day 65 and continued to P114.…”

Section: Dld Status (Dld)mentioning

confidence: 99%

Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes

et al. 2020

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Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language. In this paper, we consider the relationship between genetic variants, hearing, auditory processing and language development. We employ whole genome sequencing in a discovery family to target association and gene x environment interaction analyses in two large population cohorts; the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK10K. These investigations indicate that USH2A variants are associated with altered low-frequency sound perception which, in turn, increases the risk of developmental language disorder. We further show that Ush2a heterozygote mice have lowlevel hearing impairments, persistent higher-order acoustic processing deficits and altered vocalizations. These findings provide new insights into the complexity of genetic mechanisms serving language development and disorders and the relationships between developmental auditory and neural systems.

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“…In this study, we explored cochlear synaptopathy in aged Mongolian gerbils ( Meriones unguiculatus ), a well-established animal model of age-related cochlear degeneration and hearing loss (reviewed by [ 35 , 36 ]). The main advantages of the gerbil are its relatively short lifespan, a hearing range that includes lower frequencies that overlap with that of humans, and its amenability to behavioral training for psychoacoustic tests [ 37 ]. Moreover, our gerbils live their entire life in a controlled, quiet environment, which minimizes potentially confounding effects of noise and ototoxic substances.…”

Section: Introductionmentioning

confidence: 99%

Cochlear Ribbon Synapses in Aged Gerbils

Bovee,

Klump,

Pyott

et al. 2024

IJMS

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In mammalian hearing, type-I afferent auditory nerve fibers comprise the basis of the afferent auditory pathway. They are connected to inner hair cells of the cochlea via specialized ribbon synapses. Auditory nerve fibers of different physiological types differ subtly in their synaptic location and morphology. Low-spontaneous-rate auditory nerve fibers typically connect on the modiolar side of the inner hair cell, while high-spontaneous-rate fibers are typically found on the pillar side. In aging and noise-damaged ears, this fine-tuned balance between auditory nerve fiber populations can be disrupted and the functional consequences are currently unclear. Here, using immunofluorescent labeling of presynaptic ribbons and postsynaptic glutamate receptor patches, we investigated changes in synaptic morphology at three different tonotopic locations along the cochlea of aging gerbils compared to those of young adults. Quiet-aged gerbils showed about 20% loss of afferent ribbon synapses. While the loss was random at apical, low-frequency cochlear locations, at the basal, high-frequency location it almost exclusively affected the modiolar-located synapses. The subtle differences in volumes of pre- and postsynaptic elements located on the inner hair cell’s modiolar versus pillar side were unaffected by age. This is consistent with known physiology and suggests a predominant, age-related loss in the low-spontaneous-rate auditory nerve population in the cochlear base, but not the apex.

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The Mongolian Gerbil as a Model for the Analysis of Peripheral and Central Age-Dependent Hearing Loss

Cited by 7 publications

References 78 publications

Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model

Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model

Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes

Cochlear Ribbon Synapses in Aged Gerbils

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