The morphology, typical combinations of polymorphic genes of hemostasis, and specific features of the pathogenesis of retrochorial hematoma in missed abortion

Ap, Milovanov; Кузнецова, Н.Б.; Буштырева, И. О.

doi:10.17116/patol20167853-8

Cited by 6 publications

(4 citation statements)

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“…Aetiopathogenesis of a non-developing pregnancy is known to be multifaceted, and one of its components is microthrombosis of placental bed vessels [ 21 , 32 ]. In our study, such thrombosis can be caused by an increased level of prothrombin activity, determined at the gestational age of 7–8 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that in the works presented only the genotype was taken into account, and its phenotypic manifestation represented by an increase in prothrombin activity was not considered. Meanwhile, it is obvious that the previously described vascular microthromboses of the placental bed in women with genetic thrombophilia [ 18 – 21 ] are to be associated with a hypercoagulable shift due to the excessive activity of Factor II [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

et al. 2021

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Objective To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes. Material and methods A prospective clinical cohort study was conducted on 290 pregnant women (average age 31.7 ± 4.7 years old). The main group was made up of 140 G20210A patients, while the control group comprised 150 women with the wild G20210G type. The aim was to evaluate the activity of Factor II in the venous blood plasma during the stages of pregnancy with regard to trophoblast invasion waves. As per results, association analysis of Factor II activity value and gestational complications was carried out. Results In the control group, the median (Me) of Factor II activity ranged from 108% (preconception period) to 144% (pregnancy) [95% CI 130–150]. In patients with the GA type, the value was significantly higher in related periods, ranging from 149 to 181% [95% CI 142–195], p < 0.0001. With Factor II activity ranging from 148.5 to 180.6%, pregnancies in the main group had no complications. Higher levels of Factor II activity were associated with the development of early and/or severe preeclampsia (PE) and fetal growth retardation (FGR). Conclusion The data obtained regarding Factor II activity in blood plasma, juxtaposed with the development of great obstetrical syndromes, allow to assume that manifestation of G20210A in early and/or severe PE and FGR is associated with this coagulation factor’s level of activity. Threshold value of the Factor II activity with G20210A mutation, allowing to predict the development of PE, comprised 171.0% at the preconception stage (AUC – 0.86; p < 0.0001) and within 7–8 weeks of gestation it was 181.3% (AUC – 0.84; p < 0.0001).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

et al. 2021

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“…As for the clinical manifestations of the formation of RHG, various variants of the course are possible, depending on the location, the volume of the hematoma, the causes that lead to its formation, the existing hemostasis disorders, etc. Supracervical located hematomas are always accompanied by external bleeding, which is not always an unfavourable option [5,6]. Many studies prove that the evacuation of blood clots from the resulting cavity is a sign of positive dynamics.…”

Section: Introductionmentioning

confidence: 99%

Features of retrochoir hematomas and their effect on the course of pregnancy

Koshova

Lubkovska

2022

Eureka: HS

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The aim. Study of the features of retrochoir hematomas (RHG) and their influence on the formation of the placenta, the course of pregnancy, as well as the occurrence of premature birth. Materials and methods. 2 groups of pregnant women were selected depending on the frequency of RHG formation: 1 group – 60 pregnant women with recurrent RHG, group 2 – 50 pregnant women with RHG, which was detected only in the early stages of pregnancy. extragenital and genital pathology did not differ reliably. All the women studied were anamnesis, examined, and ultrasound and dopplerometry were performed. Statistical methods included an assessment of statistical significance using Student's t-criterion and criterion X2 and were considered significant at p<0.05. Results. Supracervical localization of hematomas prevailed in the studied pregnant women, namely: in group 1 – 51.7 % (in 31 pregnant women) and 68 % (in 34 women) in group 2. The same pattern was observed regarding the involution of hematomas. Changes in the yolk sac were found in both groups with RHG (in 6.7 % of women (i.e., in 4 pregnant women) of group 1 and 4 % (in 2 pregnant women) of group 1. Mean values of the pulsation index (PI) of blood flow velocity curves in the uterine arteries (UA) and umbilical cord artery (UCA) in pregnant women with RHG were higher than the standard average for gestational age. In pregnant RHGs, a history of various types of fetal growth retardation (FGR) is detected. The number of early forms of URP was higher in group 1 (16.7 %, i.e. in 10 pregnant women) as opposed to group 2 (2.0 %, i.e. 1 case). The late form was approximately the same amount in both groups. Also, group 1 was characterized by a significantly larger number of FGR of 2-3 centuries. In addition, in both groups with RHG, such pathological conditions were identified during pregnancy as the threat of premature birth, premature placental maturation, placental hypoplasia, oligohydramnios, and hydramnios. Conclusions. Pregnant women with recurrent RHG compared to pregnant women with sporadic RHGs have a greater number of complications during pregnancy, including the threat of preterm labour, premature placental maturation, placental hypoplasia, oligohydramnios, hydramnios, FGR, impaired uterine-placental and placental-fetal blood flow.

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“…It should be noted that in the works presented only the genotype was taken into account, and its phenotypic manifestation represented by an increase in prothrombin activity was not considered. Meanwhile, it is obvious that the previously described vascular microthromboses of the placental bed in women with genetic thrombophilia [18][19][20][21] are to be associated with a hypercoagulable shift due to the excessive activity of Factor II 22 .…”

Section: Introductionmentioning

confidence: 99%

Great Obstetrical Syndromes In G20210a Mutation Carriers Associated With High Prothrombin Activity

Николаева

Моmot

Zainulina

et al. 2020

Preprint

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Objective: to study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes.Material and methods: A prospective clinical cohort study was conducted on 290 pregnant women (average age 31.7±4.7 years old). The main group was made up of 140 G20210A patients, while the control group comprised 150 women with the wild G20210G type. The aim was to evaluate the activity of Factor II in the venous blood plasma during the stages of pregnancy with regard to trophoblast invasion waves. As per results, association analysis of Factor II activity value and gestational complications was carried out.Results: In the control group, the median (Me) of Factor II activity ranged from 108% (preconception period) to 144% (pregnancy) [95% CI 130-150]. In patients with the GA type, the value was significantly higher in related periods, ranging from 149% to 181% [95% CI 142-195], p<0.0001. With Factor II activity ranging from 148.5% to 180.6%, pregnancies in the main group had no complications. Higher levels of Factor II activity were associated with the development of early and/or severe preeclampsia (PE) and fetal growth retardation (FGR).Conclusion: The data obtained regarding Factor II activity in blood plasma, juxtaposed with the development of great obstetrical syndromes, allow to assume that manifestation of G20210A in early and/or severe PE and FGR is associated with this coagulation factor's level of activity. Threshold value of the Factor II activity with G20210A mutation, allowing to predict the development of PE, comprised 171.0% at the preconception stage (AUC – 0.86; p<0.0001) and within 7-8 weeks of gestation it was 181.3% (AUC – 0.84; p<0.0001).

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The morphology, typical combinations of polymorphic genes of hemostasis, and specific features of the pathogenesis of retrochorial hematoma in missed abortion

Cited by 6 publications

References 9 publications

Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

Features of retrochoir hematomas and their effect on the course of pregnancy

Great Obstetrical Syndromes In G20210a Mutation Carriers Associated With High Prothrombin Activity

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