The Morris Water-Escape Task in Mice: Strain Differences and Effects of Intra-Maze Contrast and Brightness

Klapdor, Karin; Staay, Franz Josef van der

doi:10.1016/s0031-9384(96)00224-7

Cited by 72 publications

(33 citation statements)

References 29 publications

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“…In fact, we (Schoepke et al 1991;Bernasconi-Guastalla et al 1994;Wolfer et al 1997) and others (Upchurch & Wehner, 1988;Paylor et al 1993Paylor et al , 1994Klapdor & van der Staay, 1996;Montkowski et al 1997;Owen et al 1997;Crawley et al 1997;Balogh et al 1999) have found marked differences between inbred strains with respect to their ability to learn the Morris swimming navigation test. We have also observed clear differences between individuals of genetically heterogeneous populations (Schoepke et al 1991;Bernasconi-Guastalla et al 1994).…”

Section: Genetic Background and Environmentmentioning

confidence: 54%

Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?

Wolfer

Lipp

2000

Exp. Physiol.

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Section: Genetic Background and Environmentmentioning

confidence: 54%

Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?

Wolfer

Lipp

2000

Exp. Physiol.

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“…The ability to remember and process spatial information, which is impaired in humans with AD (25), can be tested readily in mice. Various versions of the Morris water maze test (26) have been used to reveal behavioral deficits in mouse models (12)(13)(14)(27)(28)(29). Our version of this test was based on pilot experiments which showed that it was sensitive to the in vivo CNS effects of apoE3 and apoE4.…”

Section: Resultsmentioning

confidence: 99%

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

Raber

Wong

Buttini

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

341

250

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Apolipoprotein E (apoE) mediates the redistribution of lipids among cells and is expressed at highest levels in brain and liver. Human apoE exists in three major isoforms encoded by distinct alleles ( 2 , 3 , and 4 ). Compared with APOE 2 and 3 , APOE 4 increases the risk of cognitive impairments, lowers the age of onset of Alzheimer's disease (AD), and decreases the response to AD treatments. Besides age, inheritance of the APOE 4 allele is the most important known risk factor for the development of sporadic AD, the most common form of this illness. Although numerous hypotheses have been advanced, it remains unclear how APOE 4 might affect cognition and increase AD risk. To assess the effects of distinct human apoE isoforms on the brain, we have used the neuron-specific enolase (NSE) promoter to express human apoE3 or apoE4 at similar levels in neurons of transgenic mice lacking endogenous mouse apoE. Compared with NSE-apoE3 mice and wild-type controls, NSE-apoE4 mice showed impairments in learning a water maze task and in vertical exploratory behavior that increased with age and were seen primarily in females. These findings demonstrate that human apoE isoforms have differential effects on brain function in vivo and that the susceptibility to apoE4-induced deficits is critically influenced by age and gender. These results could be pertinent to cognitive impairments observed in human APOE 4 carriers. NSE-apoE mice and similar models may facilitate the preclinical assessment of treatments for apoErelated cognitive deficits.

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“…This raises the possibility that supplementation could change swimming speed which can confound results for the MWM (Klapdor and van der Stay 1996). Mean swimming speed, however, proved virtually identical on either treatment.…”

Section: Morris Water Mazementioning

confidence: 97%

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

Aksenov

Long

Liu

et al. 2011

AGE

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We developed a complex dietary supplement designed to offset five key mechanisms of aging and tested its effectiveness in ameliorating age-related cognitive decline using a visually cued Morris water maze test. All younger mice (<1 year old) learned the task well. However, older untreated mice (>1 year) were unable to learn the maze even after 5 days, indicative of strong cognitive decline at older ages. In contrast, no cognitive decline was evident in older supplemented mice, even when ∼2 years old. Supplemented older mice were nearly 50% better at locating the platform than age-matched controls. Brain weights of supplemented mice were significantly greater than controls, even at younger ages. Reversal of cognitive decline in activity of complexes III and IV by supplementation was significantly associated with cognitive improvement, implicating energy supply as one possible mechanism. These results represent proof of principle that complex dietary supplements can provide powerful benefits for cognitive function and brain aging.

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The Morris Water-Escape Task in Mice: Strain Differences and Effects of Intra-Maze Contrast and Brightness

Cited by 72 publications

References 29 publications

Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?

Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice

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