The mosquito microbiota influences vector competence for human pathogens

Dennison, Nathan; Jupatanakul, Natapong; Dimopoulos, George

doi:10.1016/j.cois.2014.07.004

Cited by 198 publications

(175 citation statements)

References 103 publications

(80 reference statements)

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“…Arthropods are no exception and the literature is rich with examples of various arthropod-microbiota associations that modulate essential aspects of the arthropod life cycle including reproductive fitness, survival and vectorial competence [4-6]. Arthropods vector human, livestock and plant pathogens worldwide and pose a tremendous health and economic burden [7, 8].…”

Section: Tick Microbiome: Old Players Hold New Hopementioning

confidence: 99%

Tick microbiome: the force within

Narasimhan

Fikrig

2015

Trends in Parasitology

275

261

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Ticks are obligate blood-feeders and serve as vectors of human and livestock pathogens worldwide. Defining the tick microbiome and deciphering the interactions between the tick and its symbiotic bacteria in the context of tick development and pathogen transmission, will likely reveal new insights and spawn new paradigms to control tick-borne diseases. Descriptive observations on the tick microbiome that began almost a century ago serve as forerunners to the gathering momentum to define the tick microbiome in greater detail. This review will focus on the current efforts to address the microbiomes of diverse ticks, and the evolving understanding of tick microbiomes. There is hope that these efforts will bring a holistic understanding of pathogen transmission by ticks.

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Section: Tick Microbiome: Old Players Hold New Hopementioning

confidence: 99%

Tick microbiome: the force within

Narasimhan

Fikrig

2015

Trends in Parasitology

275

261

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“…During the mosquito infection cycle, Plasmodium parasites encounter a variety of resident microbiota both in the mosquito midgut and other tissues. Numerous studies have shown that certain species of bacteria can inhibit Plasmodium development 2– 4 . For example, Enterobacter bacteria that reside in the Anopheles midgut can inhibit the development of Plasmodium parasites prior to their invasion of the midgut epithelium 5, 6 .…”

Section: Introductionmentioning

confidence: 99%

Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa

Jeffries¹,

Lawrence²,

Golovko³

et al. 2018

Wellcome Open Res

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Background: Wolbachia, a common insect endosymbiotic bacterium that can influence pathogen transmission and manipulate host reproduction, has historically been considered absent from the Anopheles (An.) genera, but has recently been found in An. gambiae s.l. populations. As there are numerous Anopheles species that have the capacity to transmit malaria, we analysed a range of species to determine Wolbachia prevalence rates, characterise novel Wolbachia strains and determine any correlation between the presence of Plasmodium, Wolbachia and the competing endosymbiotic bacterium Asaia. Methods: Anopheles adult mosquitoes were collected from five malaria-endemic countries: Guinea, Democratic Republic of the Congo (DRC), Ghana, Uganda and Madagascar, between 2013 and 2017. Molecular analysis of samples was undertaken using quantitative PCR, Sanger sequencing, Wolbachia multilocus sequence typing (MLST) and high-throughput amplicon sequencing of the bacterial 16S rRNA gene. Results: Novel Wolbachia strains were discovered in five species: An. coluzzii, An. gambiae s.s., An. arabiensis, An. moucheti and An. species ‘A’, increasing the number of Anopheles species known to be naturally infected. Variable prevalence rates in different locations were observed and novel strains were phylogenetically diverse, clustering with Wolbachia supergroup B strains. We also provide evidence for resident strain variants within An. species ‘A’. Wolbachia is the dominant member of the microbiome in An. moucheti and An. species ‘A’, but present at lower densities in An. coluzzii. Interestingly, no evidence of Wolbachia/Asaia co-infections was seen and Asaia infection densities were also shown to be variable and location dependent. Conclusions: The important discovery of novel Wolbachia strains in Anopheles provides greater insight into the prevalence of resident Wolbachia strains in diverse malaria vectors. Novel Wolbachia strains (particularly high-density strains) are ideal candidate strains for transinfection to create stable infections in other Anopheles mosquito species, which could be used for population replacement or suppression control strategies.

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“…While several studies have investigated the effect of the bacterial microbiome on Plasmodium infection in Anopheles mosquitoes [24,25], it is also evident the microbiome modulates arboviral vector competence. Most studies employ antibiotic treatment or reinfection of cultured microbes to perturb the microbiome.…”

Section: Influence On Vector Competencementioning

confidence: 99%

The microbiome modulates arbovirus transmission in mosquitoes

Hegde

Rasgon

Hughes

2015

Current Opinion in Virology

175

156

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Mosquito-transmitted arthropod-borne viruses (arboviruses) such as dengue virus, chikungunya virus, and West Nile virus constitute a major public health burden and are increasing in severity and frequency worldwide. The microbiota associated with mosquitoes (comprised of viruses, bacteria, fungi and protozoa) can profoundly influence many host phenotypes including vector competence, which can either be enhanced or suppressed. Thus, the tripartite interactions between the mosquito vector, its microbiota and the pathogens they transmit offer novel possibilities to control arthropod-borne diseases.

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The mosquito microbiota influences vector competence for human pathogens

Cited by 198 publications

References 103 publications

Tick microbiome: the force within

Tick microbiome: the force within

Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa

The microbiome modulates arbovirus transmission in mosquitoes

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