The most common cow’s milk allergenic proteins regarding to allergic symptoms

Shoormasti, Raheleh Shokouhi; Pourpak, Zahra; Yazdanyar, Zahra; Lebaschi, Zahra; Teymourpour, Pegah; Barzegar, Saeedeh; Tazesh, Behnaz; Fazlollahi, Mohammed Reza; Movahedi, Masoud; Dashti, Parisa; Moin, Mostafa

doi:10.1186/2045-7022-1-s1-p62

Cited by 4 publications

(6 citation statements)

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“…Bos d 4 has a compact and spherical conformation, with two structural domains: a large α-helical domain at the N-terminal and a short β-sheet domain at the C-terminal, flanking the calcium-binding loop [89]. Bos d 4 exhibits high sequence homology with α-lactalbumins of several species, including humans [90] and it has been identified as a major allergen in cow's milk, being commonly responsible for eliciting respiratory, cutaneous and gastrointestinal symptoms, and often anaphylaxis in milkallergic individuals [24,91].…”

Section: Glycoside Hydrolase Family 22mentioning

confidence: 99%

“…Bos d 5 is a major whey protein and a major allergen, corresponding to 10% of the total protein content of cow's milk and participates in several molecular transport processes [59]. Clinical symptoms induced by IgE-binding to Bos d 5 are quite similar to the ones triggered by Bos d 4, which involve cutaneous, gastrointestinal and respiratory manifestations (or even anaphylaxis) [91]. Additionally, Bos d 5 is reported as a potential molecular marker for persistent cow's milk allergy in adults [114].…”

Section: Lipocalinsmentioning

confidence: 99%

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Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Costa

Villa

Verhoeckx

et al. 2021

Clinic Rev Allerg Immunol

112

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Key determinants for the development of an allergic response to an otherwise 'harmless' food protein involve different factors like the predisposition of the individual, the timing, the dose, the route of exposure, the intrinsic properties of the allergen, the food matrix (e.g. lipids) and the allergen modification by food processing. Various physicochemical parameters can have an impact on the allergenicity of animal proteins. Following our previous review on how physicochemical parameters shape plant protein allergenicity, the same analysis was proceeded here for animal allergens.We found that each parameter can have variable effects, ranging on an axis from allergenicity enhancement to resolution, depending on its nature and the allergen. While glycosylation and phosphorylation are common, both are not universal traits of animal allergens. High molecular structures can favour allergenicity, but structural loss and uncovering hidden epitopes, can also have a similar impact. We discovered that there are important knowledge gaps in regard to physicochemical parameters shaping protein allergenicity both from animal and plant origin, mainly because the comparability of the data is poor. Future biomolecular studies of exhaustive, standardized design together with strong validation part in the clinical context, together with data integration model systems will be needed to unravel causal relationships between physicochemical properties and the basis of protein allergenicity.

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Section: Glycoside Hydrolase Family 22mentioning

confidence: 99%

Section: Lipocalinsmentioning

confidence: 99%

Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Costa

Villa

Verhoeckx

et al. 2021

Clinic Rev Allerg Immunol

112

View full text Add to dashboard Cite

show abstract

“…Similarly, in other similar studies, 55-70% of the patients were boys (29)(30)(31)(32). However, in none of these studies gender differences were statistically significant in patients.…”

Section: -1-1 Study Participantsmentioning

confidence: 49%

“…In the present study, 6% of patients had gastrointestinal symptoms. However, in some similar studies, 20-40% of the patients had gastrointestinal symptoms (30,32,33). Another study reported that lower age children, often have gastrointestinal symptoms and higher age children, often have respiratory and cardiovascular symptoms (34).…”

Section: -1-4 Clinical Signs and Symptomsmentioning

confidence: 94%

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Risk factors, clinical symptoms, diagnostic methods, management and treatment of patients with anaphylaxis in Tehran

Mohsenzadeh

Sohrabi

Movahedi

et al. 2021

Preprint

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Introduction: Recent studies have evaluated the risk factors, clinical symptoms, diagnostic methods, management and treatment of anaphylaxis in different populations, but the results of various studies are contradictory. The aim of this study was to evaluate the risk factors, clinical symptoms, diagnostic methods, management and treatment of anaphylactic patients referred to the Children's Medical Center of Tehran during the years 2015-2016.Materials and Methods: In this cross-sectional study, 30 patients with anaphylaxis were studied. The study population included all patients who had been diagnosed with anaphylaxis without age limitation and during the period from 2015 to 2016 to undergo serum beta-tryptase examination were referred to the laboratory of the Children's Medical Center of Tehran. The sampling method was census-based and the information was collected through a pre-designed questionnaire by examining patient files or telephone contacts with patients. After collecting data, the data were entered into SPSS 22 software and analyzed statistically. Finally, P<0.05 was considered statistically significant.Results: In our study, we investigated 30 patients with anaphylaxis, an average age of 25±15 years (range 2 to 60 years) among which 13 (43%) were men and 17 (57%) women.The most important cause of anaphylaxis in the studied patients was foods (57%), followed by drugs (20%), unknown (20%) and pollen plants (3%). About 33.7% of patients had allergies to specific allergens. The most routes of exposure with allergens were, oral (56.3%), intravenous (18.7%), unknown (12.6%) and cutaneous (3.1%), respectively. 33.6% of them had positive skin tests. The most common symptoms of anaphylaxis in order of frequency were respiratory (72.9%), cutaneous (48.8%), cardiovascular (18.6%) and gastrointestinal symptoms (6%). Eighty percent of anaphylaxis occurred at home. The most commonly prescribed medications were corticosteroids (83.3%), antihistamine (76%), epinephrine (60%) and beta-agonists (3%). Only 30% of the patients had access to Epipen.Conclusion: According to the results of this study, since most anaphylactic reactions occur in the home and more than one-third of patients had allergic to certain allergens and two-thirds of patients had a history of anaphylaxis, it seems that by providing the necessary training and knowledge to individuals with regard to allergenic substances or allergenic drugs, as well as increased access for patients to Epipen, we can prevent the occurrence and risk of subsequent anaphylaxis in these people.

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Recent Developments in Processing, Functionality, and Food Applications of Microparticulated Proteins

Dai

Stone

et al. 2021

Food Reviews International

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The most common cow’s milk allergenic proteins regarding to allergic symptoms

Cited by 4 publications

References 0 publications

Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Risk factors, clinical symptoms, diagnostic methods, management and treatment of patients with anaphylaxis in Tehran

Recent Developments in Processing, Functionality, and Food Applications of Microparticulated Proteins

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