The most potent antilithiatic agent ameliorating renal dysfunction and oxidative stress from Bergenia ligulata rhizome

Aggarwal, Deepika; Kaushal, Rajeev; Kaur, Tarundeep; Bijarnia, Rakesh Kumar; Puri, Sanjeev; Singla, Sumit

doi:10.1016/j.jep.2014.10.013

Cited by 35 publications

(23 citation statements)

References 37 publications

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“…Consistent with previous studies by our group (Sharma et al 2015;Aggarwal et al 2014) administration of EG and NH 4 Cl led to induction of hyperoxaluria and renal dysfunction in male wistar rats, as characterized by increased urinary excretion of oxalate and impaired creatinine clearance, respectively (Table 1). Concomitant administration of rottlerin to hyperoxaluric rats maintained creatinine clearance and urinary excretion of calcium and free oxalate ions, but there was no significant change in alkaline phosphatase level in serum.…”

Section: Amelioration Of Renal Injury and Crystal Load By Rottlerinsupporting

confidence: 92%

“…Total redox capability by Fe 3+ -Fe 2+ transformation at different concentrations of rottlerin and hydrogen peroxide scavenging capacity of rottlerin was measured (Aggarwal et al 2014). Briefly, the ability to reduce potassium ferricyanide [K 3 Fe(CN) 6 ] was measured at 700 nm.…”

Section: In-vitro Redox Ability Assaymentioning

confidence: 99%

“…ROT1 group rats were given intraperitoneal dose of 1 mg/kg/day alone for 9 days. The standardization of the hyperoxaluric rat model was already done in the lab from previous studies (Aggarwal et al 2014). …”

Section: Animals and Treatment Schedulementioning

confidence: 99%

“…Oxidant/antioxidant status in whole renal tissue was determined by assaying malondialdehyde (MDA) content, superoxide dismutase (SOD), catalase (CAT) and redox ratio; and in renal mitochondria by measuring redox ratio, glutathione peroxidase (GPx) and glutathione reductase (GR) by the methods as described previously (Veena et al 2008;Aggarwal et al 2014)…”

Section: Measurement Of Oxidant/antioxidant Status In Renal Tissue Anmentioning

confidence: 99%

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Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats

2016

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Section: Amelioration Of Renal Injury and Crystal Load By Rottlerinsupporting

confidence: 92%

Section: In-vitro Redox Ability Assaymentioning

confidence: 99%

Section: Animals and Treatment Schedulementioning

confidence: 99%

Section: Measurement Of Oxidant/antioxidant Status In Renal Tissue Anmentioning

confidence: 99%

See 2 more Smart Citations

Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats

2016

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“…which is known to possess antiplasmodial, immunomodulatory, hepatoprotective and diuretic properties. 8 , 9 , 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro and in vivo antileishmanial potential of bergenin rich Bergenia ligulata (Wall.) Engl. root extract against visceral leishmaniasis in inbred BALB/c mice through immunomodulation

Kaur

2018

Journal of Traditional and Complementary Medicine

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BackgroundMedicinal plants with immunomodulatory properties can provide good alternative therapeutics for curing visceral leishmaniasis. Bergenia ligulata (Wall.) Engl. is an interesting plant with strong antioxidant, antimicrobial, immunomodulatory and hepatoprotective properties.AimThe present study was planned to determine the antileishmanial activity of plant extract by modulating the immune responses of inbred BALB/c mice.MethodologyBergenin, the principle active component of B. ligulata, was quantitated in crude extract by performing RP-HPLC. The therapeutic potential was assessed through in vitro antileishmanial activity and in mice model through parasite load, cytokine assays, IgG antibody levels, DTH responses, histopathology and biochemical enzyme assays.ResultsB. ligulata showed the presence of glycosides, saponins, carbohydrates, tannins, flavonoids and bergenin which contributed to the antileishmanial activity of extract with IC50 of 22.70 μg/mL. Furthermore, the higher dose significantly reduced the parasite load by 95.56 %. The reduction was further associated with significant enhancement of IL-12 and IFN-γ levels in comparison to IL-10 and IL-4 cytokines. The switching towards Th1 type of immune response was also confirmed by elevated antibody levels of IgG2a isotype as compared to IgG1 as well as increased DTH responses. The histology of liver and kidney further complimented the non toxic nature of plant extract in addition to its negligible toxicity on HeLa cells.ConclusionsThe current study revealed the significant antileishmanial and immunomodulatory properties of this plant extract against murine visceral leishmaniasis. Further, the bioactive components will be explored to assess their efficacy for the development of safe and cost effective drug.

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Bergenia ciliata Sternb. Saxifragaceae

Jan¹,

Sher²,

Rahman³

et al. 2021

Ethnobotany of the Himalayas

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The most potent antilithiatic agent ameliorating renal dysfunction and oxidative stress from Bergenia ligulata rhizome

Cited by 35 publications

References 37 publications

Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats

Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats

Evaluation of in vitro and in vivo antileishmanial potential of bergenin rich Bergenia ligulata (Wall.) Engl. root extract against visceral leishmaniasis in inbred BALB/c mice through immunomodulation

Bergenia ciliata Sternb. Saxifragaceae

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