The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos

Bulfone, Alessandro; Kim, Hee-Joong; Puelles, Luis; Porteus, Matthew H.; Grippo, Joseph F.; Rubenstein, John L.R.

doi:10.1016/0925-4773(93)90071-5

Cited by 202 publications

(110 citation statements)

References 43 publications

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“…The domain of mEvf-1 expression in the wild-type embryo was similar to that of Dlx1, Dlx2, and Dlx5 (Bulfone et al, 1993;Eisenstat et al, 1999), corresponding to two forebrain domains. The first domain of expression encompassed the ventral thalamus and parts of the hypothalamus (Fig.…”

Section: Resultsmentioning

confidence: 78%

“…Within these regions expression follows a temporal sequence: Dlx2, Dlx1, Dlx5, and then Dlx6. In the developing subpallium (future basal ganglia) Dlx1 and Dlx2 are expressed largely in the proliferating cells of the ventricular and subventricular zone (SVZ), whereas Dlx5 and Dlx6 are expressed in progressively more differentiated cells (Bulfone et al, 1993;Porteus et al, 1994;Anderson et al, 1997b;Eisenstat et al, 1999), suggesting that this gene family is involved in the regulation of different stages in the production of forebrain cells. This hypothesis is supported by the differentiation defects observed in Dlx mutants (Anderson et al, 1997a,b;Long et al, 2003;Perera et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Identification and characterization of a novel transcript down‐regulated in Dlx1/Dlx2 and up‐regulated in Pax6 mutant telencephalon

Faedo¹,

Quinn

Stoney

et al. 2004

Developmental Dynamics

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By using a custom-made array containing cDNAs preferentially expressed in the mouse embryonic telencephalon (Porteus et al. [1992] Brain Res Mol Brain Res 12:7-22; and Alessandro Bulfone, unpublished data), we studied the gene expression profile of the Dlx1/Dlx2 -/-subpallium and Pax6 -/-pallium. We identified a transcript corresponding to Unigene Cluster Mm.94021 and rat Evf-1, which is down-regulated in the Dlx1/Dlx2 -/-subpallium and up-regulated in the Pax6 -/-pallium. Here, we report the expression pattern of this transcript, designated mouse Evf1 (mEvf1), in the prenatal forebrain of wild-type, Dlx1/Dlx2 -/-and Pax6 -/-mice using RNA in situ hybridization and reverse transcriptase-polymerase chain reaction. In the wild-type forebrain mEvf1 expression is restricted to the ventral thalamus, hypothalamus, and subpallial telencephalon (caudal, lateral, and medial ganglionic eminences and septal primordia), whereas it is down-regulated in the Dlx1/Dlx2 -/-subpallium (mainly in caudal, lateral, and medial ganglionic eminences), and up-regulated in the Pax6 -/-lateral and ventral pallium at embryonic day 12.5 and in the dorsal, lateral, and ventral pallium at embryonic day 14.5. Developmental Dynamics 231:614 -620, 2004.

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Section: Resultsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Identification and characterization of a novel transcript down‐regulated in Dlx1/Dlx2 and up‐regulated in Pax6 mutant telencephalon

Faedo¹,

Quinn

Stoney

et al. 2004

Developmental Dynamics

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“…In vertebrates, all Dlx genes except zebrafish dlx2b, are expressed in ectomesenchymal cells derived from the cranial neural crest (Dollé et al, 1992;Bulfone et al, 1993;Akimenko et al, 1994;Robinson and Mahon, 1994;Simeone et al, 1994;Qiu et al, 1997;Yang et al, 1998;Davideau et al, 1999;Myojin et al, 2001;Neidert et al, 2001). The migratory neural crest cells populate the branchial arches, which in turn give rise to much of the craniofacial skeleton and connective tissue (Depew et al, 2002).…”

Section: In the Zebrafish DLX Genes Are Expressed In The Visceral Skmentioning

confidence: 99%

“…The migratory neural crest cells populate the branchial arches, which in turn give rise to much of the craniofacial skeleton and connective tissue (Depew et al, 2002). In the mouse, members of the Dlx gene family are expressed early in cranial neural crest cells and later in craniofacial mesenchyme (Dollé et al, 1992;Bulfone et al, 1993;Robinson and Mahon, 1994;Simeone et al, 1994;Qiu et al, 1997;Yang et al, 1998;Acampora et al, 1999;Depew et al, 1999). Dlx gene expression is subsequently found in differentiating skeletal tissues (such as the skeletal derivatives of all pharyngeal arches but also bones composing the base and roof of the skull; Acampora et al, 1999).…”

Section: In the Zebrafish DLX Genes Are Expressed In The Visceral Skmentioning

confidence: 99%

“…The Dlx gene family is one of the multigene families encoding for homeodomain-containing transcription factors that are expressed early in cells of the cranial neural crest and later in craniofacial mesenchyme and skeletal tissues (Dollé et al, 1992;Bulfone et al, 1993;Akimenko et al, 1994;Robinson and Mahon, 1994;Simeone et al, 1994;Ellies et al, 1997;Qiu et al, 1997;Yang et al, 1998;Acampora et al, 1999;Depew et al, 1999). Although Dlx genes are generally associated with ectodermal and neuralcrest derived tissues, they are also expressed in mesoderm (Myojin et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase

Verreijdt

Debiais-Thibaud

Borday-Birraux

et al. 2006

Developmental Dynamics

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We have used dlx genes to test the hypothesis of a separate developmental program for dermal and cartilage bones within the neuro-and splanchnocranium by comparing expression patterns of all eight dlx genes during cranial bone formation in zebrafish from 1 day postfertilization (dPF) to 15 dPF. dlx genes are expressed in the visceral skeleton but not during the formation of dermal or cartilage bones of the braincase. The spatiotemporal expression pattern of all the members of the dlx gene family, support the view that dlx genes impart cellular identity to the different arches, required to make arch-specific dermal bones. Expression patterns seemingly associated with cartilage (perichondral) bones of the arches, in contrast, are probably related to ongoing differentiation of the underlying cartilage rather than with differentiation of perichondral bones themselves. Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification. Developmental Dynamics 235:1371-1389, 2006.

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Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development

Weiner

Chun

1997

J. Comp. Neurol.

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To identify genes associated with early postmitotic cortical neurons, gene fragments were examined for expression in postmitotic, but not proliferative, zones of the embryonic murine cortex. Through this approach, a novel member of the zinc finger gene family, containing 6 C2HC fingers, was isolated and named postmitotic neural gene-1, or png-1. Embryonic png-1 expression was: 1) nervous system-specific; 2) restricted to zones containing postmitotic neurons; and 3) detected in all developing neural structures examined. In the cortex, png-1 expression was first observed on embryonic day 11, correlating temporally and spatially with the known generation of the first cortical neurons. Gradients of png-1 expression throughout the embryonic central nervous system further correlated temporally and spatially with known gradients of neuron production. With development, expression remained restricted to postmitotic zones, including those containing newly-postmitotic neurons. Png-1 was also detected within two days of neural retinoic acid induction in P19 cells, and expression increased with further neuronal differentiation. These data implicate png-1 as one of the earliest molecular markers for postmitotic neuronal regions and suggest a function as a panneural transcription factor associated with neuronal differentiation.

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The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos

Cited by 202 publications

References 43 publications

Identification and characterization of a novel transcript down‐regulated in Dlx1/Dlx2 and up‐regulated in Pax6 mutant telencephalon

Identification and characterization of a novel transcript down‐regulated in Dlx1/Dlx2 and up‐regulated in Pax6 mutant telencephalon

Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): Differential involvement in the visceral skeleton and braincase

Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development

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