The mstate package for estimation and prediction in non- and semi-parametric multi-state and competing risks models

Wreede, Liesbeth C. de; Fiocco, Marta; Putter, Hein

doi:10.1016/j.cmpb.2010.01.001

Cited by 300 publications

(316 citation statements)

References 13 publications

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“…All analyses were based on intention to treat. For those who achieved CR cumulative incidences of isolated CNS or any CNS relapse, as well as testicular relapse, second malignancies and toxic deaths were constructed by the method of Kalbfleisch and Prentice 17,18 and the functions were compared with Gray's test. 19 All analyses concerning cumulative incidence were made with mstate library.…”

Section: Methodsmentioning

confidence: 99%

Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004

et al. 2009

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The Dutch Childhood Oncology Group (DCOG) has used two treatment strategies for children with acute lymphoblastic leukemia (ALL) based on Pinkel's St Jude Total Therapy or the Berlin-Frankfurt-Mü nster (BFM) backbone. In four successive protocols, 1734 children were treated. Studies ALL-6 and ALL-9 followed the Total Therapy approach; cranial irradiation was replaced by medium-dose methotrexate infusions and prolonged triple intrathecal therapy; dexamethasone was used instead of prednisone. Studies ALL-7 and ALL-8 had a BFM backbone, including more intensive remission induction, early reinduction and maintenance therapy without vincristine and prednisone pulses. The 5-year event-free survival and overall survival increased from 65.4 to 80.6% (Po0.001) and from 78.7 to 86.4% (P ¼ 0.07) in ALL-7 and ALL-9, respectively. In ALL-7 and ALL-8 National Cancer Institute (NCI) high-risk criteria, male gender, T-lineage ALL and high white blood cells (WBCs) predict poor outcome. In ALL-9 NCI criteria, gender, WBC 4100 Â 109/l, and T-lineage ALL have prognostic impact. We conclude that the chemotherapy-only approach in children with ALL in Total Therapy-based strategies and BFM-backbone treatment does not jeopardize survival and preserves cognitive functioning. This experience is implemented in the current DCOG-ALL-10 study using a BFM backbone and minimal residual disease-based stratification.

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Section: Methodsmentioning

confidence: 99%

Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004

et al. 2009

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“…Additionally, we calculated the amount of bias, which was introduced by the Kaplan-Meier survival analysis by ignoring the presence of the competing risks. All analyses have been performed using the mstate library [18,19] in R [20].…”

Section: Discussionmentioning

confidence: 99%

Cemented total hip arthroplasty revisions in patients of eighty years and older

Stroet

Ghisai

Keurentjes

et al. 2015

International Orthopaedics (SICOT)

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Purpose It is often a difficult decision whether it is safe to perform revision hip surgery in a patient of 80 years and older. Therefore we evaluated the results of cemented revisions in these elderly patients. Methods Clinical data, radiographs and complications of 49 consecutive cup and/or stem revisions in 48 patients were prospectively collected. The average age of the patients at surgery was 84 years (range, 80-92). We performed KaplanMeier (KM) analysis and also a competing risk (CR) analysis because in this series the presence of a competing event (i.e. death) prevents the occurrence of endpoint rerevision. Results Twenty-nine patients (30 hips) died without rerevision during follow-up and their data was included. The average follow-up of the 16 surviving patients was eight years (range, six to 13). Six re-operations were performed, of which three were re-revisions. Eight-year survivorship was 91.6 % (95 % confidence interval (CI) 76-97 %) for endpoint rerevision for any reason. With the CR analysis we calculated that due to the increasing number of competing events, the KM analysis overestimates the failure rate with 32 % for this endpoint. The average Harris hip score improved from 49 to 74. Mortality within three months after surgery was 6 %. One postoperative fracture occurred and six hips dislocated. Conclusion Cemented revisions can provide satisfying results in patient of 80 years and older with acceptable survivorship and complication rates.

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“…These models-due to having a specific probability distribution for time to the occurrence of next state -make statistical inference more accurate and cause the standard errors of the estimations to be smaller in ratio with the time when there were no such assumptions. Modeling of transition rates in multistate models is often identified by Cox proportional hazard model (Klein et al, 1984;Kay, 1986;Andersen, 1988;Hougaard, 1999;Andersen and Keiding, 2002;Klein and Moeschberger, 2003;Putter et al, 2007;De Wreede et al, 2010;Jackson, 2011). Neither have these studies generally used proportional hazards assumption nor did they attempt to identify a suitable parametric model as an alternative to Cox proportional hazard model.…”

Section: Introductionmentioning

confidence: 99%

Comparison between Parametric and Semi-parametric Cox Models in Modeling Transition Rates of a Multi-state Model: Application in Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute

Zare¹,

Mahmoodi²,

Mohammad³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Research on cancers with a high rate of mortality such as those occurring in the stomach requires using models which can provide a closer examination of disease processes and provide researchers with more accurate data. Various models have been designed based on this issue and the present study aimed at evaluating such models. Materials and Methods: Data from 330 patients with gastric cancer undergoing surgery at Iran Cancer Institute from 1995 to 1999 were analyzed. Cox-Snell Residuals and Akaike Information Criterion were used to compare parametric and semi-parametric Cox models in modeling transition rates among different states of a multi-state model. R 2.15.1 software was used for all data analyses. Results: Analysis of Cox-Snell Residuals and Akaike Information Criterion for all probable transitions among different states revealed that parametric models represented a better fitness. Log-logistic, Gompertz and Log-normal models were good choices for modeling transition rate for relapse hazard (state 1"state 2), death hazard without a relapse (state 1"state 3) and death hazard with a relapse (state 2"state 3), respectively. Conclusions: Although the semi-parametric Cox model is often used by most cancer researchers in modeling transition rates of multistate models, parametric models in similar situations-as they do not need proportional hazards assumption and consider a specific statistical distribution for time to occurrence of next state in case this assumption is not made -are more credible alternatives.

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The mstate package for estimation and prediction in non- and semi-parametric multi-state and competing risks models

Cited by 300 publications

References 13 publications

Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004

Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004

Cemented total hip arthroplasty revisions in patients of eighty years and older

Comparison between Parametric and Semi-parametric Cox Models in Modeling Transition Rates of a Multi-state Model: Application in Patients with Gastric Cancer Undergoing Surgery at the Iran Cancer Institute

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