The Mucus Barrier and Absorption Through the Oral Mucosa

Adams, D.

doi:10.1177/00220345750540021601

Cited by 52 publications

(30 citation statements)

References 14 publications

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“…Other constituents in saliva may be involved. The histological abnormalities reported in oral epithelium in Sjogren's syndrome by Adams (1973) may be accompanied by a surface which is more susceptible to colonisation by yeasts.…”

Section: Discussionmentioning

confidence: 94%

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Tapper-Jones¹,

Aldred²,

Walker³

1980

J Clin Pathol

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An imprint culture technique has been employed to study the prevalence and intraoral distribution of Candida albicans in 16 patients with Sjögren's syndrome and in 16 healthy controls matched for age, sex, and dental status. The prevalence and intraoral density of C. albicans was found to be significantly higher at almost all sites in the Sjögren's patients than in the controls. The distribution of candida was also altered, being significantly higher in the floor of the mouth and anterior labial sulcus in the Sjögren's group. There was an approximate inverse relationship between candida populations and rate of salivary flow. Mean candida densities were found to be significantly higher in those Sjögren's patients with detectable serum rheumatoid factor in the serum. However, patients with primary Sjögren's syndrome had significantly higher mean candida densities compared with patients with secondary Sjögren's syndrome.

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Section: Discussionmentioning

confidence: 94%

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Tapper-Jones¹,

Aldred²,

Walker³

1980

J Clin Pathol

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“…The decrease in tc of the 5 x 1 min rinses could be related to a cleansing effect by the prolonged rinsing. Mucous coatings have been shown to retain fluorescent dyes (Adams, 1975). If they also retain G, their removal would accelerate oral clearance.…”

Section: Discussionmentioning

confidence: 99%

Enamel Demineralization and the Length of Intra-oral Exposure to Different Concentrations of Glucose or Sucrose

Tehrani¹,

Goulet²,

Brudevold³

et al. 1986

J Dent Res

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Six subjects wore intra-oral devices carrying eight bovine enamel blocks which were covered with a layer of S. mutans. They rinsed their mouths for five sec, one min, or multiples of one min with a 5 or 10% glucose (G) solution. Demineralization was measured after 45 min by determining the change in iodide permeability (delta Ip) of the enamel. In addition, saliva samples, taken at intervals during the test, were analyzed for G, and the time of clearance (tc) was calculated. Demineralization scores (delta Ip) were consistently greater from the 10% than from the 5% G solution. Both solutions produced an increase in delta Ip with an increase in the rinsing time (tr). The G remaining in saliva after the rinse did not significantly affect delta Ip. The delta Ip scores showed good correlation with the final pH of the S. mutants cell mass, r = -0.77. For each rinse solution, the scores also showed good correlations with tr (r = 0.87 and 0.79) and much weaker correlations with tr + tc (r = 0.44 and 0.53). Continuous in vitro exposure to 1, 5, or 10% solutions of sucrose (S) in saliva for 30 min or more caused a linear increase in delta Ip with time with no concentration effects. A linear increase was also observed in vivo when a one-minute mouth-rinse with 10% solution of S was administered every 30 min. The findings indicate that significant demineralization may occur while carbohydrate foods are consumed, and that brushing the teeth or rinsing the mouth after meals may not be as effective against caries as is generally believed.

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“…79 However, saliva provides more than just a washing action and salivary mucin may contribute to the barrier layer of the oral mucosa. Anticholinergic drugs, which decrease salivary flow, increase permeability, 14 and Adams 80 has reported a transitory decrease in water permeability when saliva is added to human oral mucosa in vitro. Recently, Levine, Tabak and co-workers 81 ' 82 have identified a high-molecular-weight mucin (MG1), which may bind covalently to the surface of the oral epithelium.…”

Section: Chemical Nature Of the Permeability Barriermentioning

confidence: 99%

The Permeability of Oral Mucosa

1991

Critical Reviews in Oral Biology & Medicine

215

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In discussing permeability, we are describing one of the fundamental barrier functions of oral mucosa. Despite assumptions to the contrary, the oral mucosa is not a uniformly, highly permeable tissue like gut, but shows regional variation. The keratinized areas, such as gingiva and hard palate, are least permeable and nonkeratinized lining areas are most permeable. This variation appears to reflect differences in the types of lipid making up the intercellular permeability barrier in the superficial layers of the epithelium. Differences in permeability may be related to regional differences in the prevalence of certain mucosal diseases and can be utilized to advantage for local and systemic drug delivery.

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The Mucus Barrier and Absorption Through the Oral Mucosa

Cited by 52 publications

References 14 publications

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Enamel Demineralization and the Length of Intra-oral Exposure to Different Concentrations of Glucose or Sucrose

The Permeability of Oral Mucosa

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