The multi‐ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's Algerian spirometry

Abstract

BackgroundThe validation of the multi-ethnic GLI-2012 spirometric norms has been debated in several countries. However, its applicability in Algeria has not been verified.AimTo ascertain how well the GLI-2012 norms fit contemporary adult Algerian spirometric data.MethodsThis was a cross-sectional study of a convenience sample of 300 healthy non-smoker adults (50% men, age range: 18–85 years) recruited from the Algiers region general population. All participants underwent a clinical examination and a plethysmography measurement. Z-scores for some spirometric data [FEV1, FVC, FEV1/FVC and forced expiratory flow at 25–75% of FVC (FEF25-75%)] were calculated. If the average Z-score deviated by “< ± 0.5” from the overall mean, the GLI-2012 norms would be considered as reflective of contemporary Algerian spirometry.ResultsThe means±SDs of age, height, weight, FVC, FEV1, FEV1/FVC and FEF25-75% of the participants were, respectively, 48±17 years, 1.65±0.10 m, 73±14 kg, 4.04±1.04 L, 3.18±0.82 L, 0.79±0.05 and 4.09±1.09 L/s. Almost the quarter of participants were obese. The total sample means±SDs Z-scores were 0.22±0.87 for FVC, 0.04±0.88 for FEV1, -0.34±0.67 for FEV1/FVC and 0.93±0.79 for FEF25-75%. For men and women, only the means±SDs of the FEF25-75% Z-scores exceeded the threshold of “± 0.5”, respectively, 1.13±0.77 and 0.73±0.76.ConclusionResults of the present study, performed in an Algerian population of healthy non-smoking adults, supported the applicability of the GLI-2012 norms to interpret FEV1, FVC and FEV1/FVC but not the FEF25-75%.

Global Lung Function Initiative‐2012 ‘other/mixed’ spirometry reference equation provides the best overall fit for Australian Aboriginal and/or Torres Strait Islander children and young adults

“…In these situations, we relied solely on parent self-reporting to determine eligibility; however, this is common practice in similar population studies that have measured lung function. 9,10,20 We acknowledge the challenges in using self-reported data. Questionnaires are frequently impacted by recall bias and poor understanding of the questions may have affected answers particularly where English was not the first language spoken.…”

“…9 The Global Lung Function Initiative (GLI)-2012 9 recently developed allage, multi-ethnic reference equations. These reference equations span the 3-95 year age range and cover four major ethnic groups, Caucasian, African-American, North-and South-East Asian, as well as providing values for a mixed/other ethnicity group, 9 and have been validated for several population groups [10][11][12][13] including Caucasian Australians. 14 Several studies have found these reference equations to be unsuitable for some Caucasian and non-Caucasian populations.…”

The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study

“…This present study is part of a project involving four parts. The first, which was recently published [24], aimed at testing the applicability of the global lung initiative (GLI-2012) norms on a sample of healthy adults living in Algiers. The second, recently published [10], aimed to test the applicability of the Eastern Algeria plethysmographic norms [8] on a sample of healthy adults living in Algiers.…”

“…The fourth part, will be the establishment, according to recent international recommendations [25], of plethysmographic norms specific to the population of northern Algeria. For the above reasons, a large part of the methodology of this study has already been the object of previous descriptions [10, 24].…”

“…The total population was divided into four groups: a group for the development of plethysmographic norms specific to northern Algeria’ population (n = 491, 49.7% females), a group for the validation of the GLI-2012 spirometric norms (n = 300, 50.0% females) [24], a group for the validation of the Eastern Algeria plethysmographic norms (n = 453, 51.7% females) [8], and this study group (n = 66 females).…”