The multi-faceted potential of plant-derived metabolites as antimicrobial agents against multidrug-resistant pathogens

Shin, Jonghoon; Vasantha-Srinivasan, Prabhakaran; Kim, Kwang-sun

doi:10.1016/j.micpath.2018.01.043

Cited by 87 publications

(61 citation statements)

References 74 publications

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“…The emergence of antibiotic resistant bacteria due to overuse, the innate antibiotic resistance of Aeromonas species, plus limiting factors of synthetic chemicals due to their potential carcinogenic effects, acute toxicity and environmental hazards has encouraged research into promising substitutes in order to control multidrug resistant microorganisms (Mulyaningsih, Sporer, Zimmermann, Reichling, & Wink, ). Botanical derivatives, in particular plant essential oils (EOs), have shown promise as alternative therapeutic agents (da Cunha, Heinzmann, & Baldisserotto, ; Shin, Prabhakaran, & Kim, ).…”

Section: Introductionmentioning

confidence: 99%

In vitro antibacterial activity of four nano-encapsulated herbal essential oils against three bacterial fish pathogens

Gholipourkanani

Buller²,

Lymbery

2019

Aquac Res

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Bacterial pathogens causing diseases in fishes have broad host ranges, and may cause high mortality or ongoing chronic infections. Pathogen treatments using antibiotics are becoming limited due to increasing concerns for the development of resistance and environmental dissemination of bacteria harboring resistance genes.This study aimed to determine whether nano-emulsions of selected plant-derived essential oils (Origanum vulgare, Eucalyptus globulus, Melaleuca alternifolia and Lavendula angustifolia) were bacteriostatic or bactericidal to Aeromonas hydrophila, Streptococcus iniae and Photobacteriumdamselae subspecies damselae. All treatments showed antibacterial activity, and in almost all cases the activity of the nano-emulsions was superior to their essential oil counterparts. Origanum vulgare (oregano) nano-emulsion had the most effective antibacterial activity, with a minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 3.12 µg/ml against all three species; substantially better than tetracycline. The present study highlights the potential of new formulations of essential oils to enhance bacterial disease control in cultured fish.

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Section: Introductionmentioning

confidence: 99%

In vitro antibacterial activity of four nano-encapsulated herbal essential oils against three bacterial fish pathogens

Gholipourkanani

Buller²,

Lymbery

2019

Aquac Res

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“…The synergistic effect is observed when the antimicrobial activity of a combination of compounds is higher than the sum of the effects of individual compounds. Finally, the antagonism means that the activity of a combination of compounds is lower than the activities of individual compounds [22,27,160,161]. In Table S2, some examples of synergistic combinations of SMoPs and antibiotics are given, illustrating the significant reduction of bactericidal concentrations in comparison with antibiotics that are given without SMoPs.…”

Section: Safety In Numbers: Synergism In "Metabolite-metabolite" or "mentioning

confidence: 99%

“…This topic is extremely relevant today with the emergence and spread of completely drug-resistant strains of microorganisms. Many questions remain despite the fact that the antibacterial properties of secondary plant metabolites have been studied for a long time [15,[18][19][20][21][22][23][24][25][26][27][28]. First, in the huge sea of substances that are produced by plants, some are already known about, but still insufficiently studied and some are not yet discovered.…”

Section: Introductionmentioning

confidence: 99%

Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

et al. 2020

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Infectious diseases that are caused by bacteria are an important cause of mortality and morbidity in all regions of the world. Bacterial drug resistance has grown in the last decades, but the rate of discovery of new antibiotics has steadily decreased. Therefore, the search for new effective antibacterial agents has become a top priority. The plant kingdom seems to be a deep well for searching for novel antimicrobial agents. This is due to the many attractive features of plants: they are readily available and cheap, extracts or compounds from plant sources often demonstrate high-level activity against pathogens, and they rarely have severe side effects. The huge variety of plant-derived compounds provides very diverse chemical structures that may supply both the novel mechanisms of antimicrobial action and provide us with new targets within the bacterial cell. In addition, the rapid development of modern biotechnologies opens up the way for obtaining bioactive compounds in environmentally friendly and low-toxic conditions. In this short review, we ask the question: do antibacterial agents derived from plants have a chance to become a panacea against infectious diseases in the “post-antibiotics era”.

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“…The first efflux pump inhibitor against RND‐type efflux pumps, reported by Lomovskaya et al , 15 was a phenylalanine–arginine β‐naphthylamide (PAβN) effective against Mex pumps in Pseudomonas aeruginosa and AcrB pumps in E. coli . Since then, various synthetic and natural compounds have been screened for their ability to inhibit efflux pumps 16–20 …”

Section: Introductionmentioning

confidence: 99%

“…Since then, various synthetic and natural compounds have been screened for their ability to inhibit efflux pumps. [16][17][18][19][20] However, little is known about efflux inhibitors for the ABC-type pump MacAB. Here, we describe a screening of inhibitors of MacAB in Salmonella and the identification of a compound that increases the susceptibility of a MacABexpressing Salmonella strain to macrolides.…”

Section: Introductionmentioning

confidence: 99%

An efflux inhibitor of the MacAB pump in Salmonella enterica serovar Typhimurium

Yamagishi

Nakano

Yamasaki

et al. 2020

Microbiology and Immunology

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Multidrug efflux pumps play an important role in bacterial multidrug resistance by actively excreting antibiotics. The ATP‐binding cassette–type drug efflux pump MacAB was originally reported as a macrolide‐specific pump. MacAB is also known to be required for the virulence of Salmonella enterica serovar Typhimurium following oral infection in mice. Here, we performed a screening of inhibitors of Salmonella MacAB and found a compound that increased the susceptibility of a MacAB‐expressing strain to macrolides. It was previously reported that MacAB is required to resist peroxide‐mediated killing in vitro and that a supernatant of wild‐type Salmonella rescues the growth defect of a macAB mutant in H2O2. In this study, we also found that the MacAB inhibitor reduced the ability of the supernatant to rescue Salmonella cells in H2O2. This compound could lead to a better understanding of the function of MacAB.

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The multi-faceted potential of plant-derived metabolites as antimicrobial agents against multidrug-resistant pathogens

Cited by 87 publications

References 74 publications

In vitro antibacterial activity of four nano-encapsulated herbal essential oils against three bacterial fish pathogens

In vitro antibacterial activity of four nano-encapsulated herbal essential oils against three bacterial fish pathogens

Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?

An efflux inhibitor of the MacAB pump in Salmonella enterica serovar Typhimurium

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