The Multifaced Actions of Curcumin in Pregnancy Outcome

Tossetta, Giovanni; Fantone, Sonia; Giannubilo, Stefano Raffaele; Marzioni, Daniela

doi:10.3390/antiox10010126

Cited by 60 publications

(45 citation statements)

References 159 publications

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“…There are animal model studies on the use of curcumin in pregnancy. Due to the anti-inflammatory activity of this compound, the possibility of using this compound in the treatment of complications of pregnancy has been suggested, including Gestational Diabetes Mellitus, PreTerm Birth, Preeclampsia and exposure to toxic agents and pathogens [ 21 ].…”

Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

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Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there is a tendency to use natural compounds for the management of obesity. There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. Curcumin is a is an important compound present in Curcuma longa L. rhizome. It is a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as a pharmacological traditional medicinal agent in Ayurvedic medicine for ∼6000 years. This plant metabolite doubtless effectiveness has been reported through increasingly detailed in vitro, in vivo and clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes have been remarkably highlighted. This review documents the status of research on anti-obesity mechanisms and evaluates the effectiveness of curcumin for management of obesity. It summarizes different mechanisms of anti-obesity action, associated with the enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota and anti-inflammatory potential of curcumin. However, there is still a need for systematic and targeted clinical studies before curcumin can be used as the mainstream therapy for managing obesity.

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Section: Medicinal Activities Bioavailability and Metabolism Of Curcu...mentioning

confidence: 99%

Curcumin and Weight Loss: Does It Work?

Kasprzak-Drozd

Oniszczuk

Gancarz

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…Moreover, endovenous use of curcumin is safe if used if the dose administered is lower than that used orally. In pregnant animals, curcumin showed to be safe, but further studies are needed to confirm its safety in pregnant women (79,80). Curcumin is also a nontoxic, non-mutagenic, non-carcinogenic, non-photo toxic agent and considered safe at lower doses than oral doses in intravenous administration in humans.…”

Section: Curcuma Longamentioning

confidence: 99%

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

et al. 2021

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Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic proportions worldwide. Pathology’s multifactorial nature makes patient management, including lifelong drug therapy and lifestyle modification, extremely challenging. Currently, there is growing evidence about the effectiveness of using herbal supplements in preventing and controlling DM. Curcumin is a bioactive component found Curcuma longa, which exhibits several physiological and pharmacological properties such as antioxidant, anti-inflammatory, anticancer, neuroprotective, and anti-diabetic activities. For these reasons, our objective is to systematically review the effects of Curcuma longa or curcumin on DM. Databases such as PUBMED and EMBASE were searched, and the final selection included sixteen studies that fulfilled the inclusion criteria. The results showed that curcumin’s anti-diabetic activity might be due to its capacity to suppress oxidative stress and inflammatory process. Also, it significantly reduces fasting blood glucose, glycated hemoglobin, and body mass index. Nanocurcumin is also associated with a significant reduction in triglycerides, VLDL-c, total cholesterol, LDL-c, HDL-c, serum C reactive protein, and plasma malonaldehyde. Therefore, it can be considered in the therapeutic approach of patients with DM.

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“…Similarly, animal studies also indicated that rosiglitazone mitigated the decrease of placental diameter and fetal weight caused by TCS. In addition, curcumin, a natural compound and a modulator of PPARγ, has been known to have beneficial effects on pregnancy outcomes [ 53 , 54 ]. It will be interesting to know the effect of curcumin or other natural PPARγ modulators on TCS placental exposure in the future.…”

Section: Discussionmentioning

confidence: 99%

PPARγ Regulates Triclosan Induced Placental Dysfunction

Quan

Zhang

et al. 2021

Cells

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Exposure to the antibacterial agent triclosan (TCS) is associated with abnormal placenta growth and fetal development during pregnancy. Peroxisome proliferator-activated receptor γ (PPARγ) is crucial in placenta development. However, the mechanism of PPARγ in placenta injury induced by TCS remains unknown. Herein, we demonstrated that PPARγ worked as a protector against TCS-induced toxicity. TCS inhibited cell viability, migration, and angiogenesis dose-dependently in HTR-8/SVneo and JEG-3 cells. Furthermore, TCS downregulated expression of PPARγ and its downstream viability, migration, angiogenesis-related genes HMOX1, ANGPTL4, VEGFA, MMP-2, MMP-9, and upregulated inflammatory genes p65, IL-6, IL-1β, and TNF-α in vitro and in vivo. Further investigation showed that overexpression or activation (rosiglitazone) alleviated cell viability, migration, angiogenesis inhibition, and inflammatory response caused by TCS, while knockdown or inhibition (GW9662) of PPARγ had the opposite effect. Moreover, TCS caused placenta dysfunction characterized by the significant decrease in weight and size of the placenta and fetus, while PPARγ agonist rosiglitazone alleviated this damage in mice. Taken together, our results illustrated that TCS-induced placenta dysfunction, which was mediated by the PPARγ pathway. Our findings reveal that activation of PPARγ might be a promising strategy against the adverse effects of TCS exposure on the placenta and fetus.

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The Multifaced Actions of Curcumin in Pregnancy Outcome

Cited by 60 publications

References 159 publications

Curcumin and Weight Loss: Does It Work?

Curcumin and Weight Loss: Does It Work?

The Effects of Curcumin on Diabetes Mellitus: A Systematic Review

PPARγ Regulates Triclosan Induced Placental Dysfunction

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