The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

Chakraborty, Subhankar; Kaur, Sukhwinder; Guha, Sushovan; Batra, Surinder K.

doi:10.1016/j.bbcan.2012.03.008

Cited by 387 publications

(583 citation statements)

References 264 publications

(414 reference statements)

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“…Muscle-invasive BCa (>T1) was able to be differentiated from non-muscle invasive BCa (≤T1). Until now, NGAL has been investigated primarily as an inflammatory factor and marker of kidney damage (15). However, recent studies have indicated that NGAL has potential role in cancer development and that it may have pro-oncogenic or anti-oncogenic functions.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a complex of MMP-9 and human neutrophil gelatinase-associated lipocalin (NGAL) has been detected in the urine of patients with prostate cancer and BCa (14). NGAL is an acute-phase protein involved in innate immunity, with a crucial role in intracellular iron transport (15). NGAL expression is altered in several benign conditions, including inflammatory, ischemic and metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…NGAL expression is altered in several benign conditions, including inflammatory, ischemic and metabolic disorders. Furthermore, NGAL is overexpressed in numerous types of tumor (15,16), and its expression is associated with invasive cancer progression (17,18).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of MMP-2, MMP-9, TIMP-1, TIMP-2, NGAL and MMP-9/NGAL complex in urine and sera from patients with bladder cancer

Ricci¹,

Bruzzese²,

Carlo³

2015

Oncology Letters

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Abstract. The identification of biomarkers in urine or serum samples from patients with bladder cancer is urgently required for the development of non-invasive methods for the diagnosis of bladder carcinoma and to facilitate follow-up surveillance, to combat the high progression and recurrence rates of this type of cancer. The current study measured the content of matrix metalloproteinase (MMP)-2 and -9, as well as tissue inhibitor of metalloproteinase (TIMP)-1 and -2 in the urine and sera of 41 patients with bladder cancer by ELISA. The association between levels of MMP-2 and -9 and TIMP-1 and -2, and tumor grade and stage were investigated to verify whether these molecules are involved in tumor differentiation. Statistical analysis of the data revealed that urinary TIMP-1 levels were significantly higher in the high grade group compared with those of the low grade samples (P=0.022). The results also revealed a significantly differing distribution of TIMP-1 expression between Ta and T1 stage specimens (P=0.040). The corresponding area under the curves (AUCs) were 0.72, with a sensitivity of 0.70 and specificity of 0.75. In addition, neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex levels in the sera were measured. All molecules evaluated were detected in the sera of the patients studied. In particular, tumors staged as non-muscle invasive (Ta and T1), demonstrated significantly higher NGAL levels compared with those of muscle invasive (>T1) bladder cancer (32.8 ng/ml vs. 16.2 ng/ml; P=0.029). The discriminatory ability of NGAL expression was confirmed by receiver operating characteristic curve analysis that revealed an AUC of 0.75, a sensitivity of 0.88 and a specificity of 0.67. These data indicated that urinary TIMP-1 and serum NGAL may be useful non-invasive biomarkers to provide clinical information for bladder cancer disease management. Multicenter, prospective studies are required to confirm these preliminary results. IntroductionBladder cancer (BCa) is one of the most common urologic malignancies worldwide; with a higher frequency amongst males than females (1). The two major environmental risk factors for BCa are high exposure to tobacco smoke, and occupational exposure to aromatic amines, polycyclic aromatic hydrocarbons and chlorinated hydrocarbons (2,3). Furthermore, exposure to ionizing radiation, a variety of lifestyle choices, occupations, dietary factors, drugs, urologic pathologies, family history and genetic polymorphisms may increase the risk of bladder carcinoma (1-3). There are two clinical phenotypes of bladder carcinoma: Non-invasive and invasive BCa. Non-invasive BCa includes the papillary carcinoma phenotype (Ta) and flat carcinoma in situ (cis). Ta bladder carcinoma is superficial and rarely invades the basement membrane or metastasizes, but is associated with a high risk of local recurrence; while invasive bladder carcinoma has a high risk of disease progression, including muscle invasion and metastasis, and mortality. Ta tumorigenesis typically occurs via a mol...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of MMP-2, MMP-9, TIMP-1, TIMP-2, NGAL and MMP-9/NGAL complex in urine and sera from patients with bladder cancer

Ricci¹,

Bruzzese²,

Carlo³

2015

Oncology Letters

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“…This adipokine plays a role in innate immunity and acute phase response to infection, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, modulation of oxidative stress and inflammation, and metabolic homeostasis. LCN2 has been investigated as a diagnostic and prognostic biomarker in numerous pathological conditions, such as cancer, tissue injury, inflammation and autoimmunity (34,35). Recently, LCN2 has also been proposed as a possible biomarker for disease activity and clinical response to antihistamine therapy in CU.…”

Section: Metabolic Syndromementioning

confidence: 99%

The link between chronic spontaneous urticaria and metabolic syndrome

Veña¹,

Cassano²

2017

Eur Ann Allergy Clin Immunol

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Summary Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and is considered a chronic low-level systemic inflammatory condition. Recent preliminary findings have shown an increased prevalence of MS among patients with chronic urticaria (CU) as compared to controls, with a particularly higher prevalence detected in patients with uncontrolled CU. Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with MS, including a pro-inflammatory state, increased oxidative stress, alterations in adipokine profile

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“…[5][6][7][8][9] Recently a lipocalin family member glycoprotein neutrophil gelatinase-associated lipocalin (NGAL), also known as lipocalin-2, come into prominence as a cancer biomarker. [10][11][12] It is 25-kDa biomarker, and associated with cellular iron absorption, antibacterial activity and epithelial cell differentiation. NGAL was first discovered in neutrophils, and subsequently shown to be expressed in many tissues and cells.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil gelatinase- associated lipocalin as a screening test in prostate cancer

Muşlu

Ercan

Akbayir³

et al. 2017

Turkish Journal of Urology

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Objective: Prostate specific antigen (PSA) with digital rectal examination is used for diagnosis of prostate cancer (PCa), where definite diagnosis can only be made by prostate biopsy. Recently neutrophil gelatinaseassociated lipocalin (NGAL), a lipocalin family member glycoprotein, come into prominence as a cancer biomarker. This study is aimed to test serum NGAL as a diagnostic biomarker for PCa and discriminate PCa from benign prostatic hyperplasia (BPH). Material and methods:In this prospective study, 90 patients who underwent transrectal ultrasound-guided 12-core prostate biopsy between May 2015 and September 2015, were evaluated. Histopathologically diagnosed 45 PCa and 45 BPH patients were enrolled in this study. Serum NGAL and PSA levels of all participants were measured, then these data were evaluated by statistical programs. Results: When sensitivity fixed to 80% specificity of NGAL was better than PSA (49%, 31% respectively). Receiver operating characteristic (ROC) curve analysis showed that NGAL alone or its combined use with PSA have better area under curve (AUC) results than PSA alone (0.662, 0.693, and 0.623 respectively). Conclusion: In conclusion NGAL gave promising results such as increased sensitivity and a better AUC values in order to distinguish PCa from BPH. NGAL showed a potential to be a non-invasive biomarker which may decrease the number of unnecessary biopsies.

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The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

Cited by 387 publications

References 264 publications

Evaluation of MMP-2, MMP-9, TIMP-1, TIMP-2, NGAL and MMP-9/NGAL complex in urine and sera from patients with bladder cancer

Evaluation of MMP-2, MMP-9, TIMP-1, TIMP-2, NGAL and MMP-9/NGAL complex in urine and sera from patients with bladder cancer

The link between chronic spontaneous urticaria and metabolic syndrome

Neutrophil gelatinase- associated lipocalin as a screening test in prostate cancer

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