The multifunctional synergistic effect of chitosan on simvastatin loaded nanoparticulate drug delivery system

Selvasudha, Nandakumar; Koumaravelou, Kailasam

doi:10.1016/j.carbpol.2017.01.038

Cited by 21 publications

(17 citation statements)

References 16 publications

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“…The results are statistically significant for a p-value of less than 0.05, except when compared between Pur and Pur-CS/TPP-NPs. As can be seen from the pharmacokinetic results, the Pur group had the following properties: AUC0- 24 Figure 4 and Table 6 below.…”

Section: Pharmacokinetic Analysismentioning

confidence: 89%

“…We sampled 1 mL at 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 12, and 24 h, respectively, while replenishing the same amount of medium at the same temperature. The drug concentration and the cumulative release rate were calculated by filtration through a 0.22 µm microporous membrane [23,24]. The cumulative release percentage Qn% of the drug at various time points was calculated by the following formula:…”

Section: In Vitro Drug Release Experimentsmentioning

confidence: 99%

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Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics

et al. 2020

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In this paper, as an active ingredient, puerarin chitosan nanoparticles (Pur-CS/TPP-NPs) are prepared by an ionic gelation method. The chitosan (CS) concentration, pH of the CS solution, sodium tripolyphosphate (TPP) concentration, stirring speed, stirring time, ultrasonic power, and dosage are used as single factors for investigation, and the encapsulation efficiency, drug loading capacity, particle size, and polydispersity index (PDI) are used as indicators for investigation. The optimal prescription is determined using the Box–Behnken effect surface design method. The characterization of the best formulation, which is determined via an in vitro release assay and liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis methods, is used here for pharmacokinetic studies. An in situ single-pass intestinal perfusion model is used to investigate drug absorption in the intestine. After characterization, the morphologies of the nanoparticles are intact. It can be seen from the in vitro release experiments that the equation fitted by the nanoparticles is the Higuchi model, the nanoparticle release process is very stable and without sudden release, indicating that the nanoparticles are well-released in vitro. The pharmacokinetic results and the in situ single-pass intestinal perfusion model study show that the bioavailability and absorption of Pur-CS/TPP-NPs were significantly higher than Pur. Thus, all the results show that the prepared nanoparticles can significantly improve the bioavailability of Pur, and we hope to lay the foundation for the development of new products of Pur.

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Section: Pharmacokinetic Analysismentioning

confidence: 89%

Section: In Vitro Drug Release Experimentsmentioning

confidence: 99%

Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics

et al. 2020

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“…Local simvastatin (SV) delivery is a strategy successfully used to increase and anchor bone regeneration by creating scaffolds capable of releasing bioactive dosages of this drug at the application site (Li et al 2018; Wang et al 2018; Xue et al 2019; Zhang et al 2019; Hajializade et al 2020). Chitosan has been considered a suitable carrier system for poorly soluble drugs, such as SV, increasing its solubility and thereby its bioavailability for several clinical applications (Selvasudha and Koumaravelou 2017). In our previous experiments, incorporation of 1 μM SV on chitosan and chitosan-calcium-aluminate scaffolds had better results than lower dosages, increasing alkaline phosphatase (ALP) activity and mineralized matrix deposition.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Calcium-Simvastatin Scaffold as an Inductive Cell-Free Platform

Soares¹,

Bordini

Bronze‐Uhle³

et al. 2021

J Dent Res

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The development of biomaterials based on the combination of biopolymers with bioactive compounds to develop delivery systems capable of modulating dentin regeneration mediated by resident cells is the goal of current biology-based strategies for regenerative dentistry. In this article, the bioactive potential of a simvastatin (SV)–releasing chitosan-calcium-hydroxide (CH-Ca) scaffold was assessed. After the incorporation of SV into CH-Ca, characterization of the scaffold was performed. Dental pulp cells (DPCs) were seeded onto scaffolds for the assessment of cytocompatibility, and odontoblastic differentiation was evaluated in a microenvironment surrounded by dentin. Thereafter, the cell-free scaffold was adapted to dentin discs positioned in artificial pulp chambers in direct contact with a 3-dimensional (3D) culture of DPCs, and the system was sealed to simulate internal pressure at 20 cm/H2O. In vivo experiments with cell-free scaffolds were performed in rats’ calvaria defects. Fourier-transform infrared spectroscopy spectra proved incorporation of Ca and SV into the scaffold structure. Ca and SV were released upon immersion in a neutral environment. Viable DPCs were able to spread and proliferate on the scaffold over 14 d. Odontoblastic differentiation occurred in the DPC/scaffold constructs in contact with dentin, in which SV supplementation promoted odontoblastic marker overexpression and enhanced mineralized matrix deposition. The chemoattractant potential of the CH-Ca scaffold was improved by SV, with numerous viable and dentin sialoprotein–positive cells from the 3D culture being observed on its surface. Cells at 3D culture featured increased gene expression of odontoblastic markers in contact with the SV-enriched CH-Ca scaffold. CH-Ca-SV led to intense mineralization in vivo, presenting mineralization foci inside its structure. In conclusion, the CH-Ca-SV scaffold induces differentiation of DPCs into a highly mineralizing phenotype in the presence of dentin, creating a microenvironment capable of attracting pulp cells to its surface and inducing the overexpression of odontoblastic markers in a cell-homing strategy.

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“…[10][11][12] However, it is required to overcome multiple obstacles for realizing these complex steps, because the specic requirements on charge, size or stability of nanocarrier at each stage are different. [13][14][15][16] Therefore, how to incorporate multiple nano-characteristics required at each stage into one nanocarrier system for overcoming multi-stage biological barriers remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

Zhang

Duan

et al. 2021

RSC Adv.

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The multifunctional synergistic effect of chitosan on simvastatin loaded nanoparticulate drug delivery system

Cited by 21 publications

References 16 publications

Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics

Preparation of Puerarin Chitosan Oral Nanoparticles by Ionic Gelation Method and Its Related Kinetics

Chitosan-Calcium-Simvastatin Scaffold as an Inductive Cell-Free Platform

pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

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