The Muscarinic Acetylcholine Receptor-Stimulated Increase in Aquaporin-5 Levels in the Apical Plasma Membrane in Rat Parotid Acinar Cells Is Coupled with Activation of Nitric Oxide/cGMP Signal Transduction

Ishikawa, Yasuko; Iida, Hirokazu; Ishida, Hideyuki

doi:10.1124/mol.61.6.1423

Cited by 57 publications

(56 citation statements)

References 36 publications

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“…Conversely, A23187, a calcium ionophore (44), alone increases the amount of AQP5 in the APM and decreases the amount of AQP5 in the Triton X-100-insoluble fraction (21). These findings indicate that an increase in the intracellular calcium concentration ([Ca (45,47). This increase coincides with the increased AQP5 levels in the APM in rat parotid gland cells.…”

Section: Intracellular Signals For the Translocation Of Aqp5 Towards supporting

confidence: 51%

Water Channels and Zymogen Granules in Salivary Glands

et al. 2006

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Abstract. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. The molecular mechanisms underlying the secretion of water, a main component of saliva, from salivary glands are not known; the plasma membrane is a major barrier to water transport. A 28-kDa integral membrane protein, distributed in highly waterpermeable tissues, was identified as a water channel protein, aquaporin (AQP). Thirteen AQPs (AQP0 -AQP12) have been identified in mammals. AQP5 is localized in lipid rafts under unstimulated conditions and translocates to the apical plasma membrane in rat parotid glands upon stimulation by muscarinic agonists. The importance of increases in intracellular calcium concentration [Ca 2+ ] i and the nitric oxide synthase and protein kinase G signaling pathway in the translocation of AQP5 is reviewed in section I. Signals generated by the activation of Ca 2+ mobilizing receptors simultaneously trigger and regulate exocytosis. Zymogen granule exocytosis occurs under the control of essential process, stimulus-secretion coupling, in salivary glands. Ca 2+ signaling is a principal signal in both protein and water secretion from salivary glands induced by cholinergic stimulation. On the other hand, the cyclic adenosine monophosphate (cAMP)/ cAMP-dependent protein kinase system has a major role in zymogen granule exocytosis without significant increases in [Ca 2+ ] i . In section II, the mechanisms underlying the control of salivary protein secretion and its dysfunction are reviewed.

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Section: Intracellular Signals For the Translocation Of Aqp5 Towards supporting

confidence: 51%

Water Channels and Zymogen Granules in Salivary Glands

et al. 2006

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“…The transmembrane water flux via the regulation of aquaporin quantity and activity endows plants with a remarkable capacity to modulate water absorption, transport and compartmentation within tissues. In animal studies, the role of NO/cGMP signal transduction in the M3 muscarinic acetylcholine receptor-stimulated increase in AQP5 levels in the apical plasma membrane of rat parotid glands was reported [34]. Pretreatment of rat parotid tissue with the NO scavenger inhibited acetylcholine-induced increases in AQP5 in the apical plasma membrane.…”

Section: Discussionmentioning

confidence: 99%

“…NO/cGMP signal transduction has a crucial role in Ca 2+ homeostasis in the M3 muscarinic acetylcholine-stimulated increase in AQP5 levels in the apical plasma membrane of rat parotid glands [34]. NO plays a role in seed germination, yet little is understood about how it functions.…”

Section: Effects Of No On Pip Transcript Levels In Germinating Seedmentioning

confidence: 99%

The role of water channel proteins and nitric oxide signaling in rice seed germination

et al. 2007

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Previous studies have demonstrated the possible role of several aquaporins in seed germination. But systematic investigation of the role of aquaporin family members in this process is lacking. Here, the developmental regulation of plasma membrane intrinsic protein (PIP) expression throughout germination and post-germination processes in rice embryos was analyzed. The expression patterns of the PIPs suggest these aquaporins play different roles in seed germination and seedling growth. Partial silencing of the water channel genes, OsPIP1;1 and OsPIP1;3, reduced seed germination while over-expression of OsPIP1;3 promoted seed germination under water-stress conditions. Moreover, spatial expression analysis indicates that OsPIP1;3 is expressed predominantly in embryo during seed germination. Our data also revealed that the nitric oxide (NO) donors, sodium nitroprusside (SNP) and S-nitrosoglutathione (GSNO), promoted seed germination; furthermore, the NO scavenger, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, inhibited germination and reduced the stimulative effects of SNP and GSNO on rice germination. Exogenous NO stimulated the transcription of OsPIP1;1, OsPIP1;2, OsPIP1;3 and OsPIP2;8 in germinating seeds. These results suggest that water channels play an important role in seed germination, acting, at least partly, in response to the NO signaling pathway.

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“…Finally, AQP5, which has a major role in the generation of saliva, tears and pulmonary secretions, has been shown to translocate to the plasma membrane of rat parotid cells upon stimulation with the M3 muscarinic GPCR agonist, acetylcholine, or the adrenergic receptor agonist, adrenaline (Ishikawa et al, 1999). Internalisation of AQP5 was observed following prolonged exposure to acetylcholine (Ishikawa et al, 1998a, Ishikawa et al, 2002.…”

Section: What Triggers Aqp Translocation?mentioning

confidence: 99%

“…The use of specific inhibitors has revealed that the mechanism of acetylcholine-induced AQP5 translocation is mediated by cGMP, calmodulin and protein kinase G (Ishikawa et al, 2002).…”

Section: Protein Kinase Gmentioning

confidence: 99%

An emerging consensus on aquaporin translocation as a regulatory mechanism

Conner

Bill

Conner

2012

Molecular Membrane Biology

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Water can pass through the cell membrane relatively slowly by diffusion. However, in order to maintain water homeostasis, the rapid and specific regulation of cellular water flow is mediated by the aquaporin (AQP) family of membrane protein water channels. Thirteen human AQPs have been identified to date and the majority are highly specific for water while others show selectivity for water, glycerol and other small solutes. The wide range of tissues that are known to express AQPs is reflected by their involvement in many physiological processes and diseases. Receptor mediated translocation, via hormone activation, is an established method of AQP regulation, especially for AQP2. There is now an emerging consensus that the rapid and reversible translocation of other AQPs from intracellular vesicles to the plasma membrane, triggered by a range of stimuli, can confer increased membrane permeability. This review examines new advances that have identified molecular mechanisms of AQP regulation; these include the role of cytoskeletal proteins, kinases, calcium and retention or localisation signals as well as specific triggers of AQP translocation. This article reviews current knowledge of AQP regulation with a focus on rapid and dynamic regulation of sub-cellular AQP translocation in response to a specific trigger.3

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The Muscarinic Acetylcholine Receptor-Stimulated Increase in Aquaporin-5 Levels in the Apical Plasma Membrane in Rat Parotid Acinar Cells Is Coupled with Activation of Nitric Oxide/cGMP Signal Transduction

Cited by 57 publications

References 36 publications

Water Channels and Zymogen Granules in Salivary Glands

Water Channels and Zymogen Granules in Salivary Glands

The role of water channel proteins and nitric oxide signaling in rice seed germination

An emerging consensus on aquaporin translocation as a regulatory mechanism

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