The mutagenicity of a Prudhoe Bay crude oil and its residues from an experimental in situ burn

Sheppard, E P; Wells, R.A.; Georghiou, Paris E.

doi:10.1016/0013-9351(83)90229-3

Cited by 8 publications

(2 citation statements)

References 19 publications

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“…In contrast, the extract was most mutagenic in the frameshift strains in the absence of S9, indicating a role for nitroarenes. Although Sheppard et al [] found that the emissions from burning Prudhoe Bay crude oil were mutagenic in TA98, we cannot compare their results with ours due to the differences in collection and extraction of the samples between the two studies.…”

Section: Discussioncontrasting

confidence: 59%

“…For example, a variety of combustion emissions, such as those from diesel exhaust and cigarette smoke, have electrophilic compounds that can induce inflammation, damage to DNA, mutations, and cancer [IARC, 2004[IARC, , 2014. Sheppard et al [1983] found that a dimethyl sulfoxide (DMSO) extract of samples of the smoke plume from a controlled burn of Prudhoe Bay, Alaska, crude oil that had fallen on the surrounding ice and collected were mutagenic in strain TA98 of Salmonella. This is the only study on the mutagenicity of emissions from burning oil per se, and it did not employ standard procedures to collect and extract the emissions, nor were measurements made to permit the calculation of a mutagenicity emission factor.…”

Section: Introductionmentioning

confidence: 99%

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Mutagenicity and oxidative damage induced by an organic extract of the particulate emissions from a simulation of the deepwater horizon surface oil burns

DeMarini

Warren

Lavrich

et al. 2017

Environ and Mol Mutagen

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Emissions from oil fires associated with the "Deepwater Horizon" explosion and oil discharge that began on April 20, 2010 in the Gulf of Mexico were analyzed chemically to only a limited extent at the time but were shown to induce oxidative damage in vitro and in mice. To extend this work, we burned oil floating on sea water and performed extensive chemical analyses of the emissions (Gullett et al., Marine Pollut Bull, in press, ). Here, we examine the ability of a dichloromethane extract of the particulate material with an aerodynamic size ≤ 2.5 µm (PM ) from those emissions to induce oxidative damage in human lung cells in vitro and mutagenicity in 6 strains of Salmonella. The extract had a percentage of extractable organic material (EOM) of 7.0% and increased expression of the heme oxygenase (HMOX1) gene in BEAS-2B cells after exposure for 4 hr at 20 µg of EOM/ml. However, the extract did not alter mitochondrial respiration rate as measured by extracellular flux analysis. The extract was most mutagenic in TA100 +S9, indicative of a role for polycyclic aromatic hydrocarbons (PAHs), reflective of the high concentrations of PAHs in the emissions (1 g/kg of oil consumed). The extract had a mutagenicity emission factor of 1.8 ± 0.1 × 10 revertants/megajoule in TA98 +S9, which was greater than that of diesel exhaust and within an order of magnitude of open burning of wood and plastic. Thus, organics from PM of burning oil can induce oxidative responses in human airway epithelial cells and are highly mutagenic. Environ. Mol. Mutagen. 58:162-171, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%