The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: a meta-analysis

Yang, Haiyan; Cai, Dongmiao; Zhu, Qingping; Wu, Dongjin; Wang, Qingxiang; Wang, Zhanxiang

doi:10.18632/oncotarget.16666

Cited by 7 publications

(3 citation statements)

References 43 publications

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“…This study also showed that the co-association of FAM13A rs1903003 (CC) and the β3-AR Trp64 variant is related to higher blood pressure values (SBP and DBP). Thus, these data correspond with other studies which have proved that the Trp64Arg polymorphism of the β3-AR gene is associated with increased metabolic disorders (diabetes mellitus) and hypertension risk [ 69 , 70 ].…”

Section: Discussionsupporting

confidence: 91%

The Influence of FAM13A and PPAR-γ2 Gene Polymorphisms on the Metabolic State of Postmenopausal Women

Grygiel-Górniak

Ziółkowska-Suchanek

Szymkowiak

et al. 2023

Genes

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Recently, we have observed two significant pandemics caused by communicable (COVID-19) and non-communicable factors (obesity). Obesity is related to a specific genetic background and characterized by immunogenetic features, such as low-grade systemic inflammation. The specific genetic variants include the presence of polymorphism of the Peroxisome Proliferator-Activated Receptors gene (PPAR-γ2; Pro12Ala, rs1801282, and C1431T, rs3856806 polymorphisms), β-adrenergic receptor gene (3β-AR; Trp64Arg, rs4994), and Family With Sequence Similarity 13 Member A gene (FAM13A; rs1903003, rs7671167, rs2869967). This study aimed to analyze the genetic background, body fat distribution, and hypertension risk in obese metabolically healthy postmenopausal women (n = 229, including 105 lean and 124 obese subjects). Each patient underwent anthropometric and genetic evaluations. The study has shown that the highest value of BMI was associated with visceral fat distribution. The analysis of particular genotypes has revealed no differences between lean and obese women except for FAM13A rs1903003 (CC), which was more prevalent in lean patients. The co-existence of the PPAR-γ2 C1431C variant with other FAM13A gene polymorphisms [rs1903003(TT) or rs7671167(TT), or rs2869967(CC)] was related to higher BMI values and visceral fat distribution (WHR > 0.85). The co-association of FAM13A rs1903003 (CC) and 3β-AR Trp64Arg was associated with higher values of systolic (SBP) and diastolic blood pressure (DBP). We conclude that the co-existence of FAM13A variants with C1413C polymorphism of the PPAR-γ2 gene is responsible for body fat amount and distribution.

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Section: Discussionsupporting

confidence: 91%

The Influence of FAM13A and PPAR-γ2 Gene Polymorphisms on the Metabolic State of Postmenopausal Women

Grygiel-Górniak

Ziółkowska-Suchanek

Szymkowiak

et al. 2023

Genes

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“…The familial history of comorbidities related to cardiometabolic traits (diabetes, hypertension, dyslipidemia and obesity) was not significantly associated with GIPR Glu354Gln genetic polymorphism. Hypertension associated factors were male sex, advanced age, high BMI and smoking, corroborating literature data (18, 19, 20). The mechanisms involved in the pathophysiology of hypertension arise from the interaction among environmental and genetic factors.…”

Section: Discussionsupporting

confidence: 90%

Association of theGIPRGlu354Gln (rs1800437) polymorphism with hypertension in a brazilian population

Mattos

Outuki

et al. 2018

Preprint

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25 26 Objective: To know the prevalence of the Glu354Gln polymorphism of 27 the GIPR gene, investigate possible associations with arterial hypertension and 28 relationships with cardiometabolic diseases. Method: A total of 311 subjects 29 recruited from the Clinical Hospital of Londrina State University, located in a 30 Brazilian metropolitan area. Random stratification was performed considering 31 gender and geographic regions. Data were collected through interviews 32 including anthropometric, sociodemographic and metabolic diseases related 33diseases. In order to analyze GIPR Glu354Gln gene polymorphism, 34 polymerase chain reaction followed by followed by restriction fragment length 35 polymorphism (PCR-RFLP) was performed. Results: The highest prevalence 36 for the allele C carriers were found in the Caucasian 29.4% (p = 0.043, OR = 37 1,89), hypertensive 37.1% (p < 0.0001), smokers 38.3% (p = 0.014) and 38 dyslipidemic group 41.2% (p = 0.019). In this work 46.9% of the participants (n 39 = 146) presented diseases related to cardiometabolic diseases. The results 40 indicated that 60% of hypertensive patients (p = 0.004) and 64.7% of 41 dyslipidemic patients (p = 0.046) were male. Among participants who presented 42 cardiometabolic diseases, arterial hypertension was the most prevalent disease 43 (71.9%), followed by obesity (43.8%). The family comorbidities history to 44 cardiometabolic diseases (DM2, AH, dyslipidemia and obesity) had no 45 significant association with the GIPR Glu354Gln genetic polymorphism. 46Although there was no difference in the case-control analyses for GIPR 47 3 48 twice associated with arterial hypertension (p<0,001) and dyslipidemia 49 (p<0,03). Conclusion: The prevalence of the GIPR Glu354Gln for the CC 50 genotype and for the C polymorphic allele was 25.7% and 3.2%, respectively. 51This study shows the potential participation of the GIPR Glu354Gln 52 polymorphism with the pathophysiology of arterial hypertension, dyslipidemia 53 in this Brazilian population. Taking into account the rarity of the CC genotype, 54 additional studies with larger numbers of participants could contribute to a 55 better understanding. 56 57 65 adipocytes, pancreas, lung, adrenal, kidney and thyroid (1). Nonpancreatic 66 GIPR function is related to adrenal cell proliferation, GIP-dependent 67 oversecretion of cortisol and aldosterone (4, 5, 6) and neurogenesis in the 68 central nervous system (6). 69 Several GIP receptor polymorphisms have been described. These 70 genetic variations could play a role on gluco-insulin homeostasis and body 4 4 71 composition. Some single nucleotide polymorphisms (SNPs) located in coding 72 regions of the GIPR gene (rs8111428, rs2302382 and rs1800437) were related 73 to obesity (7). The GIPR rs10423928 was associated with high postprandial 74 glucose and insulin levels (8), decreased lean mass (9) and low BMD in early 75 postmenopausal women (10). The GIPR SNP rs1800437 (Glu354Gln) showed 76 a borderline association with cardiovascular disease (CVD) in a study of 200 77 p...

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“…또한 CAMK4, ADRB3 그리고 CYP11B2 유전자와 같이 고 혈압에 영향을 미치는 유전적 요인에 대한 연구도 활발 하게 진행되고 있다 (Li and Liu, 2014;Chen et al, 2016;Yang et al, 2017 (Zotova et al, 2016). 특히 안지오텐신 II 유형1 수용체(Angiotensin II type 1 receptor, AT1R)을 생성하는 ATR1(또는 AGRT1) 유전자의 유전적 다형성은 메타 분석을 통하여 아시아인 과 백인에서 고혈압 발병 위험과 관련이 있음이 확인되 었다 (Liu et al, 2015).…”

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Genetic Polymorphisms ofARMC4, LRP4andBCL2Genes are Associated with Blood Pressure Traits and Hypertension in Korean Population

Park

Jeon

Kim

et al. 2020

BSL

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High blood pressure (HTN) is a condition in which blood pressure is kept higher than normal. Blood pressure trait measures systolic blood pressure (SBP) which is the highest pressure and diastolic blood pressure (DBP) which is the lowest blood pressure. Pulse pressure (PP) is the difference between systolic and diastolic blood pressure. Hypertension is known as a disease caused by the interaction of the environment and genetic factors. To date, studies have been conducted to find genes associated with hypertension. Genome-Wide Association Study (GWAS) analysis using European data from the UK Biobank reported new 535 loci were associated with blood pressure trait. Among them, 12 genes have been reported to have a significant correlation with SBP, DBP and PP. In the study, 12 genes polymorphisms were extracted based on KARE (Korean association resource) and then we performed linear regression of blood pressure trait. As a result, 6 SNPs of the 3 genes (rs12355413 and rs11006736 of ARMC4, rs2290883, rs2290884 and rs11039014 of LRP4, rs7234941 of BCL2) showed statistically significant correlation (P<0.05) with blood pressure trait. Of the 3 genes, 6 SNPs in 2 genes (rs9651357, rs12355413, rs11006736, rs1889522 of ARMC4 and rs4987774, rs7234941 of BCL2) showed significant correlation with hypertension. These results suggest that genetic polymorphisms of ARMC4, LRP4 and BCL2 genes are associated with blood pressure traits and hypertension in Korean population. Moreover, we expected to help understand the pathogenesis of hypertension.

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The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: a meta-analysis

Cited by 7 publications

References 43 publications

The Influence of FAM13A and PPAR-γ2 Gene Polymorphisms on the Metabolic State of Postmenopausal Women

The Influence of FAM13A and PPAR-γ2 Gene Polymorphisms on the Metabolic State of Postmenopausal Women

Association of theGIPRGlu354Gln (rs1800437) polymorphism with hypertension in a brazilian population

Genetic Polymorphisms ofARMC4, LRP4andBCL2Genes are Associated with Blood Pressure Traits and Hypertension in Korean Population

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