The Mystery of Collagen Cross-linking When it Comes to In Vivo Biomechanical Measurements

Gatinel, Damien

doi:10.3928/1081597x-20141021-02

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…19 Clinicians should be cautious when interpreting Corvis ST results. The postoperative biomechanical changes of the cornea especially in KCN may be too subtle to be measured, 40 and thus pose insignificant results. Corvis ST measures biomechanics of the entire corneal thickness.…”

Section: Discussionmentioning

confidence: 99%

Corneal biomechanical outcome of collagen cross-linking in keratoconic patients evaluated by Corvis ST

Jabbarvand

Moravvej

Shahraki

et al. 2020

European Journal of Ophthalmology

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Purpose: A 6-month evaluation of the topographic and biomechanical changes induced by corneal collagen cross-linking (CXL) in keratoconic eyes using Pentacam and Corvis ST. Design: Longitudinal prospective case series. Methods: In this study, 67 eyes of 67 patients with progressive keratoconus (KCN) treated with “Epithelium-off” CXL were evaluated. Patients with stages 1 or 2 of KCN and a corneal thickness of at least 400 μm at the thinnest point were included. Standard ophthalmologic examinations were carried out for all patients. The topographic and biomechanical measurements of the cornea were obtained by Pentacam (Oculus Optikgeräte GmbH, Wetzlar, Germany) and Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) preoperatively and 6-month postoperatively. Results: The mean age of the participants was 21.68 ± 4.23 years. There was significant difference in mean spherical equivalent (SE) before and 6 months after CXL. Uncorrected and best corrected visual acuity improved postoperatively, although not statistically significant. The mean and maximum keratometry showed a significant decrease 6 months after CXL (0.93 ± 0.38 D and 1.43 ± 0.62 D, respectively p < 0.001). Among Corvis ST parameters, first applanation length and velocity (AL1 and AV1) showed statistically significant changes. The radius at highest concavity changed significantly (0.13 ± 0.37 mm mean increase after CXL; p < 0.001). A significant increase was observed in stiffness parameter A1 (SP-A1; p < 0.001) and significant decreases were noted in integrated radius (IR) and deformation amplitude ratio (DAR; p < 0.001). Conclusion: Analyzing biomechanical changes after corneal cross-linking can provide basis for efficient KCN treatment. Corvis ST parameters demonstrated changes in corneal biomechanical characteristics indicative of stiffing after CXL.

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Section: Discussionmentioning

confidence: 99%

Corneal biomechanical outcome of collagen cross-linking in keratoconic patients evaluated by Corvis ST

Jabbarvand

Moravvej

Shahraki

et al. 2020

European Journal of Ophthalmology

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“…Several studies have evaluated the reduction in corneal biomechanical strength following LASIK,23–26 and following ReLEx flex and ReLEx smile procedures, suggesting similar corneal biomechanical reduction among these laser refractive procedures 27 28. However, there is inconclusive evidence in the peer review literature on the specificity of these techniques in the in-vivo evaluation of the effect of corneal cross-linking 29 30…”

Section: Discussionmentioning

confidence: 99%

High-irradiance CXL combined with myopic LASIK: flap and residual stroma biomechanical properties studied ex-vivo

et al. 2015

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“…Several studies have evaluated the reduction in corneal biomechanical strength following refractive surgeries such as LASIK. However, there is inconclusive evidence in the peer-review literature on the specificity of these techniques in the evaluation of the effect of corneal cross-linking [ 8 ].…”

Section: The Need For Comparative Evaluation Of CXL Protocolsmentioning

confidence: 99%

Cross-Linking and Corneal Imaging Advances

Kanellopoulos

Krueger

Asimellis

2015

BioMed Research International

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The Mystery of Collagen Cross-linking When it Comes to In Vivo Biomechanical Measurements

Cited by 8 publications

References 5 publications

Corneal biomechanical outcome of collagen cross-linking in keratoconic patients evaluated by Corvis ST

Corneal biomechanical outcome of collagen cross-linking in keratoconic patients evaluated by Corvis ST

High-irradiance CXL combined with myopic LASIK: flap and residual stroma biomechanical properties studied ex-vivo

Cross-Linking and Corneal Imaging Advances

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