The N200 abnormalities of auditory event-related potentials in patients with panic disorder

Wang, Jijun; Miyazato, Hiroshi; Randall, Maxine; Hokama, Hiroto; Hiramatsu, Ken‐Ichi; Ogura, Chikara

doi:10.1016/s0278-5846(03)00169-6

Cited by 22 publications

(16 citation statements)

References 29 publications

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“…Conversely, Turan, Esel, Karaaslan, Basturk, Oguz, and Yabanoglu (2002) reported a significant prolongation of P300 latency in a panic disorder group using an auditory oddball paradigm without any differences for earlier components. Moreover, Wang, Miyazato, Randall, Hokama, Hiramatsu, and Ogura (2003) found a reduction of the N200 component in female subjects suffering from panic disorder during an active discrimination task, and no differences for the P300 component were described between patients and controls.…”

Section: Panic Disordermentioning

confidence: 85%

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Hansenne

2006

PSYCHOL BELG

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Since the discovery of the P300 component, a large number of studies have been conducted with the aim to find abnormalities of this psychophysiological marker among the main psychiatric disorders. The first studies were very promising, but successive findings were rather controversial resulting in two main positions (the pros and the cons) as regard to the usefulness of P300 in clinical psychopathology. However, P300 studies provide interesting findings concerning information processing in psychopathology. Moreover, other Event-Related Potentials (ERPs), such as the Mismatch Negativity (MMN) and the Error-Related Negativity (ERN) are particularly interesting for the study of cognitive processes in psychopathology. In this review, the author will give an overview of the main findings of P300, MMN and ERN values in psychopathology from a clinical and a cognitive point of view. After a brief description of the rationale of ERPs, the findings in schizophrenia, depression, alcoholism, posttraumatic stress disorder, panic disorder, and obsessive-compulsive disorder will be sequentially reviewed. The diagnostic usefulness of P300 in psychopathology is limited, but could be increased if variables known to influence P300 amplitude or latency are controlled. Doubtless, grouping two or more different ERP components would greatly improve the usefulness of the clinical applications of brain potentials. On the other hand, a growing number of studies have provided evidence of the relevance of ERPs to investigate cognitive processes in psychopathology.

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Section: Panic Disordermentioning

confidence: 85%

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Hansenne

2006

PSYCHOL BELG

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“…Oddball N2 reflects the detection of a mismatch within a stimulus stream (Folstein and van Petten, 2008). Although reduced oddball N2 amplitude in PD was previously reported (Wang et al, 2003), the small number of patients showing that ERP abnormality renders the finding unreliable. Interpretations of P2 include attentional modulation of nontarget stimuli (Novak et al, 1992) and stimulus classification (GarciaLarrea et al, 1992), and the component is believed to represent a functionally discrete stage of neural processing (Crowley and Colrain, 2004).…”

Section: N2 and P2mentioning

confidence: 87%

“…Iwanami et al (1997) additionally found increased N1 to relevant oddball stimuli (infrequent targets), which correlated with self-reported state anxiety in PD, suggesting a contribution of cortical arousal. In contrast, other investigators reported no group effect for N1 (e.g., Clark et al, 1996;Wang et al, 2003). Increased P3a to rare target and distractor tones within a three-tone oddball task (Clark et al, 1996) and decreased P3 amplitudes to target tones within a standard two-tone oddball task (Gordeev, 2008) have been reported, reflecting disturbances in passive and active attentional mechanisms in PD, respectively (Muller-Gass and Campbell, 2002).…”

Section: Introductionmentioning

confidence: 96%

Event-related potential and autonomic signs of maladaptive information processing during an auditory oddball task in panic disorder

Wise

McFarlane

Clark

et al. 2009

International Journal of Psychophysiology

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“…N2 has been observed in an oddball task [Wang et al, 2003] and a recognition memory task [Kim et al, 2001]. With regard to the functional significance of N2, it is generally accepted that N2 constitutes an index of stimulus identification and categorization, and that it reflects the extraction of information required for the operation of later cognitive components, most notably P3 [Renault et al, 1982].…”

Section: Discussionmentioning

confidence: 99%

Electrophysiological correlates of behavioral response inhibition in patients with obsessive–compulsive disorder

Kim

Yoo

et al. 2006

Depress. Anxiety

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In this study, we have attempted to determine the electrophysiological correlates of behavioral response inhibition in patients with obsessive-compulsive disorder (OCD). To evaluate response inhibition ability, we have used the Go/NoGo task and measured N2 and P3 event-related potential (ERP) components. Both the OCD and control groups exhibited greater and more frontally distributed N2 and P3 amplitudes in the NoGo condition compared to what we observed in the Go condition. However, the patients with OCD also manifested reduced NoGo-N2 and Go-N2 amplitudes at the frontocentral electrode sites compared to the controls. In addition, the NoGo-N2 amplitudes were more posteriorly distributed in patients with OCD than in controls. The NoGo-N2 amplitudes and latencies measured at the central sites were also negatively correlated with the obsession score on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The OCD and control groups were comparable with regard to Go-P3 and NoGo-P3 amplitude and latencies. Our findings suggest dysfunctions in frontal regions mediating response inhibition in OCD, consistent with the involvement of response inhibition in the pathophysiology of this disorder. In addition, NoGo-N2 seems to result in more accurate response inhibition measurements in patients with OCD than does NoGo-P3. Depression and Anxiety 24:22-31, 2007.

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The N200 abnormalities of auditory event-related potentials in patients with panic disorder

Cited by 22 publications

References 29 publications

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Event-related potential and autonomic signs of maladaptive information processing during an auditory oddball task in panic disorder

Electrophysiological correlates of behavioral response inhibition in patients with obsessive–compulsive disorder

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