The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma

Ma, Yu; Liu, Yan; Wang, Yurui; Guo, Yanzhu; Li, Yuanyuan; Li, Ruizhi; Kong, Xinzi; Han, Qize; Wei, Rong; Wang, Jing

doi:10.1016/j.matdes.2022.110838

Cited by 13 publications

(2 citation statements)

References 43 publications

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“…Considerable research have outlined the vasodilatory effects , cardiovascular advantages, anti-inflammation effects, and potential therapeutic applications in Alzheimer’s disease . Notably, recent studies have discerned the inhibitory effects of EVO on various tumor cells, − supported by its modulation of critical signaling pathways such as NF-κB, mTOR, PI3K/AKT, Wnt/β-catenin, and JAK-STAT within tumor cells. − EVO exhibits a multifunctional antitumor profile by inducing cell cycle arrest, promoting cell apoptosis, and impeding invasion and metastasis . Jiang et al also underscore its potential in tumor immunotherapy, as EVO downregulates MUC1-C mRNA, leading to reduced expression of PD-L1 and heightened immune cell infiltration in tumors .…”

Section: Introductionmentioning

confidence: 99%

Cell Membrane Camouflaged Biomimetic Nanocomplex Based on Black Phosphorus Nanosheets to Modulate T Cells for Melanoma Immunotherapy

Qin,

Pang,

Kong

et al. 2024

ACS Appl. Nano Mater.

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Malignant melanoma, a particularly aggressive and lethal tumor, has traditionally been treated through methods such as surgery, radiation therapy, and chemotherapy. Unfortunately, these methods frequently show some limitations, such as suboptimal therapeutic effectiveness, notable adverse effects, and the propensity for the development of drug resistance. Targeted therapy and immunotherapy hold substantial promise for extending the survival of patients and elevating their overall quality of life. Nevertheless, the prevalence of "cold tumors" continues to hamper the effectiveness of these treatments, resulting in unsatisfactory outcomes for many patients. Facing this challenge, nanomedicine emerges as a good frontier, functioning as an advanced drug delivery system that integrates immunotherapy with additional anticancer strategies. Hence, there is substantial research on malignant melanoma. This study introduces a multifunctional nanoplatform that combines evodiamine, black phosphorus nanosheets, and tumor cell membranes. The tumor cell membrane imparts the nanoplatform immune evasion capabilities and enhances precision in tumor targeting. Simultaneously, the effects of black phosphorus nanosheets and evodiamine synergistically impede tumor cell growth by the combination of photothermal, chemotherapy, and immunotherapy approaches, ultimately leading to an amplified immune response.

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Section: Introductionmentioning

confidence: 99%

Cell Membrane Camouflaged Biomimetic Nanocomplex Based on Black Phosphorus Nanosheets to Modulate T Cells for Melanoma Immunotherapy

Qin,

Pang,

Kong

et al. 2024

ACS Appl. Nano Mater.

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“…In relation to the therapeutic effectiveness of quantum dots (QDs), in a recent investigation conducted by Ma et al. (2022) , Graphene Quantum Dots (GQDs) that were functionalized with folic acid (FA) were employed as a targeted vehicle for the administration of evodiamine (EVO).…”

Section: Introductionmentioning

confidence: 99%

Tunable theranostics: innovative strategies in combating oral cancer

Uthman,

AL-Rawi,

Saeed

et al. 2024

PeerJ

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Objective This study aims to assess and compare the potential of advanced nano/micro delivery systems, including quantum dots, carbon nanotubes, magnetic nanoparticles, dendrimers, and microneedles, as theranostic platforms for oral cancer. Furthermore, we seek to evaluate their respective advantages and disadvantages over the past decade. Materials and Methods A comprehensive literature search was performed using Google Scholar and PubMed, with a focus on articles published between 2013 and 2023. Search queries included the specific advanced delivery system as the primary term, followed by oral cancer as the secondary term (e.g., “quantum dots AND oral cancer,” etc.). Results The advanced delivery platforms exhibited notable diagnostic and therapeutic advantages when compared to conventional techniques or control groups. These benefits encompassed improved tumor detection and visualization, enhanced precision in targeting tumors with reduced harm to neighboring tissues, and improved drug solubility and distribution, leading to enhanced drug absorption and tumor uptake. Conclusion The findings suggest that advanced nano/micro delivery platforms hold promise for addressing numerous challenges associated with chemotherapy. By enabling precise targeting of cancerous cells, these platforms have the potential to mitigate adverse effects on surrounding healthy tissues, thus encouraging the development of innovative diagnostic and therapeutic strategies for oral cancer.

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Evodiamine and its nano‐based approaches for enhanced cancer therapy: recent advances and challenges

Solanki,

Patel

2024

J Sci Food Agric

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Evodiamine is a bioactive alkaloid extracted from the Evodia rutaecarpa plant. It has various pharmacological effects including anti‐cancer, anti‐bacterial, anti‐obesity, anti‐neurodegenerative, anti‐depressant, and cardiac protective properties. Evodiamine demonstrates potent anti‐cancer activity by inhibiting the proliferation of cancer cells in vitro and in vivo. Despite the health‐promoting properties of evodiamine, its clinical use is hindered by low water solubility, poor bioavailability, and toxicity. Thus, there is a need to develop alternative drug delivery systems for evodiamine to enhance its solubility, permeability, and stability, as well as to facilitate targeted, prolonged, and controlled drug release. Nanocarriers can increase the therapeutic potential of evodiamine in cancer therapy while reducing adverse side effects. To date, numerous attempts have been made through the development of smart nanocarriers to overcome the drawbacks of evodiamine. This review focuses on the pharmacological applications, anti‐cancer mechanisms, and limitations of evodiamine. Various nanocarriers, including lipid‐based nanoparticles, polymeric nanoparticles, cyclodextrins, and so forth, have been discussed extensively for evodiamine delivery. Nano‐drug delivery systems could increase the solubility, bioavailability, stability, and therapeutic efficacy of evodiamine. This review aims to present a comprehensive and critical evaluation of several nano‐formulations of evodiamine for cancer therapy. © 2024 Society of Chemical Industry.

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The nanocomposite system comprising folic acid-modified graphene quantum dots loaded with evodiamine in the treatment of oral squamous cell carcinoma

Cited by 13 publications

References 43 publications

Cell Membrane Camouflaged Biomimetic Nanocomplex Based on Black Phosphorus Nanosheets to Modulate T Cells for Melanoma Immunotherapy

Cell Membrane Camouflaged Biomimetic Nanocomplex Based on Black Phosphorus Nanosheets to Modulate T Cells for Melanoma Immunotherapy

Tunable theranostics: innovative strategies in combating oral cancer

Evodiamine and its nano‐based approaches for enhanced cancer therapy: recent advances and challenges

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