The NAS-NRC Twin Registry and Duke Twins Study of Memory in Aging: An Update

Gatz, Margaret; Plassman, Brenda L.; Tanner, Caroline M.; Goldman, Samuel; Swan, Gary E.; Chanti‐Ketterl, Marianne; Walters, Ellen E.; Butler, David A.

doi:10.1017/thg.2019.45

Cited by 5 publications

(1 citation statement)

References 22 publications

(20 reference statements)

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“…All the data used in the current study are available without any financial charge through the National Archive of Computerized Data on Aging. 6 , 7…”

Section: Methodsmentioning

confidence: 99%

Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Wang

Neale

et al. 2020

Hypertension

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Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status—a form of G×E interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White male twin pairs aged between 15 and 33 years from the National Academy of Sciences–National Research Council World War II Veteran Twin Registry. Systolic and diastolic BPs, as well as height and weight, were measured at the induction physical examination. Body mass index (BMI) was used as the index of general obesity. Quantitative genetic modeling was performed using Mx software. Univariate analysis showed that narrow sense heritabilities (95% CI) for systolic BP, diastolic BP, height, and BMI were 0.401 (0.381–0.420), 0.297 (0.280–0.320), 0.866 (0.836–0.897), and 0.639 (0.614–0.664), respectively. Positive phenotypic correlations of BMI with systolic BP (r=0.13) and diastolic BP (r=0.08) were largely due to genetic factors (70% and 86%, respectively). The gene-BMI interaction analysis did not show any support for a modifying effect of BMI on genetic and environmental influences of systolic BP and diastolic BP. Our results suggest that correlations between BP and BMI are mainly explained by common genes influencing both. Higher BMI levels have no influence on the penetrance of genetic vulnerability to elevated BP. These conclusions may prove valuable for gene-finding studies.

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“…All the data used in the current study are available without any financial charge through the National Archive of Computerized Data on Aging. 6 , 7…”

Section: Methodsmentioning

confidence: 99%

Genetic and Environmental Influences on Blood Pressure and Body Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry

Wang

Neale

et al. 2020

Hypertension

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An information‐based framework for development national twin registry: Scoping review and focus group discussion

Abtahi

Gholamzadeh

Shahmoradi

et al. 2021

Health Planning & Management

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Background: Registries in various clinical domains have been established in the last decades. The specific genetic structure of twins has enabled researchers to find answers to the role of genetics and the environment in medical sciences. Thus, twin registries were developed across the world to support twin studies. Our main objective was to devise a conceptual model for developing the national twin registry to ensure the success of this registry. Methods:In this descriptive and qualitative study, the combination of literature review and focus group discussions was applied to achieve suitable models for developing a national twin registry based on lessons learned from founded registries. The qualitative synthesis and reporting results were conducted based on the COREQ checklist. Results: According to a systematic literature review, the characteristics and employed strategies employed by established twin registries were recognized. Moreover, based on our objectives, suitable models for registry development were defined. The source of information, the different levels of data, and the information flow were determined based on this model. Conclusion: Suggesting a conceptual framework for twin registry development at the national level based on the experiences of other countries could contribute to a greater understanding of twin registry implementation efficiently.

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