The National Institutes of Health Neurobiobank: A Federated National Network of Human Brain and Tissue Repositories

Nichols, Lisa; Freund, Michelle; Ng, Cathy; Kau, Alice; Parisi, Melissa A.; Taylor, Anna; Armstrong, David M.; Avenilla, Frank; Joseph, Jeymohan; Meinecke, Doug; Wagner, Ann; Little, A. Roger

doi:10.1016/j.biopsych.2013.07.039

Cited by 14 publications

(12 citation statements)

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“…Today, there are dozens of human brain banks around the world dedicated to the collection of postmortem brain tissues after autopsies. Regional consortiums of brain banks, such as BrainNet Europe [16] and the NeuroBioBank [17] under the National Institutes of Health, USA, have been established in order to standardize the diagnosis and tissue collection procedures to provide researchers better access to large cohorts of human subjects.…”

Section: Human Brain Banksmentioning

confidence: 99%

The Study of Postmortem Human Synaptosomes for Understanding Alzheimer’s Disease and Other Neurological Disorders: A Review

Jhou

Tai

2017

Neurol Ther

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Synaptic dysfunction is thought to play important roles in the pathophysiology of many neurological diseases, including Alzheimer’s disease, Parkinson’s disease, and schizophrenia. Over the past few decades, there have been systematic efforts to collect postmortem brain tissues via autopsies, leading to the establishment of dozens of human brain banks around the world. From cryopreserved human brain tissues, it is possible to isolate detached-and-resealed synaptic terminals termed synaptosomes, which remain metabolically and enzymatically active. Synaptosomes have become important model systems for studying human synaptic functions, being much more accessible than ex vivo brain slices or primary neuronal cultures. Here we review recent advances in the establishment of human brain banks, the isolation of synaptosomes, their biological activities, and various analytical techniques for investigating their biochemical and ultrastructural properties. There are unique insights to be gained by directly examining human synaptosomes, which cannot be substituted by animal models. We will also discuss how human synaptosome research has contributed to better understanding of neurological disorders, especially Alzheimer’s disease.

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Section: Human Brain Banksmentioning

confidence: 99%

The Study of Postmortem Human Synaptosomes for Understanding Alzheimer’s Disease and Other Neurological Disorders: A Review

Jhou

Tai

2017

Neurol Ther

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“…[30][31][32][33] Dr. Akil also discussed the importance of studying sex differences in brain function and critical brain development in the context of SUD. [30][31][32][33] Dr. Akil also discussed the importance of studying sex differences in brain function and critical brain development in the context of SUD.…”

Section: Perceived Challenges and Areas For Improvementmentioning

confidence: 99%

“…There have been recent successes with regard to the convergence of transcriptomic networks across species in conserved brain regions. [30][31][32][33] Dr. Akil also discussed the importance of studying sex differences in brain function and critical brain development in the context of SUD. This is especially important when considering that women more rapidly progress to addiction than men, and the rate of opioid-related overdoses increased more sharply for women than for men between 1999 and 2015.…”

Section: Perceived Challenges and Areas For Improvementmentioning

confidence: 99%

National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies

Cates

Benca-Bachman

Guglielmo

et al. 2019

Genes Brain and Behavior

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The National Institute on Drug Abuse Genetics and Epigenetics Cross‐Cutting Research Team convened a diverse group of researchers, clinicians, and healthcare providers on the campus of the University of California, San Diego, in June 2018. The goal was to develop strategies to integrate genetics and phenotypes across species to achieve a better understanding of substance use disorders through associations between genotypes and addictive behaviors. This conference (a) discussed progress in harmonizing large opioid genetics cohorts, (b) discussed phenotypes that are used for genetics studies in humans, (c) examined phenotypes that are used for genetics studies in animal models, (d) identified synergies and gaps in phenotypic analyses of human and animal models and (e) identified strategies to integrate genetics and genomics data with phenotypes across species. The meeting consisted of panels that focused on phenotype harmonization (Dr. Laura Bierut, Dr. Olivier George, Dr. Dan Larach and Dr. Sesh Mudumbai), translating genetic findings between species (Dr. Elissa Chesler, Dr. Gary Peltz and Dr. Abraham Palmer), interpreting and understanding allelic variations (Dr. Vanessa Troiani and Dr. Tamara Richards) and pathway conservation in animal models and human studies (Dr. Robert Hitzemann, Dr. Huda Akil and Dr. Laura Saba). There were also updates that were provided by large consortia (Dr. Susan Tapert, Dr. Danielle Dick, Dr. Howard Edenberg and Dr. Eric Johnson). Collectively, the conference was convened to discuss progress and changes in genome‐wide association studies.

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“…Human post-mortem studies are most suitable in this respect, but data available is limited as these studies face multiple practical issues in the collection of tissue from a sufficient amount to appropriate subjects, together with a detailed subject history of SLEs, stressrelated pathology, and use of medication. Longitudinal studies (Yehuda 2004), as well as increased storage and application of human post-mortem data in biobank tissue repositories, like the USA's National Institutes of Health Neurobiobank (Nichols et al 2014), are necessary to increase insight in the brain region-specific epigenetic profiles associated with stress-related psychopathology.…”

Section: Human Studiesmentioning

confidence: 99%

Epigenetic programming of the neuroendocrine stress response by adult life stress

Dirven

Homberg

Kozicz

et al. 2017

Journal of Molecular Endocrinology

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The hypothalamic-pituitary-adrenal (HPA) axis is critically involved in the neuroendocrine regulation of stress adaptation, and the restoration of homeostasis following stress exposure. Dysregulation of this axis is associated with stress-related pathologies like major depressive disorder, post-traumatic stress disorder, panic disorder and chronic anxiety. It has long been understood that stress during early life can have a significant lasting influence on the development of the neuroendocrine system and its neural regulators, partially by modifying epigenetic regulation of gene expression, with implications for health and well-being in later life. Evidence is accumulating that epigenetic plasticity also extends to adulthood, proposing it as a mechanism by which psychological trauma later in life can long-lastingly affect HPA axis function, brain plasticity, neuronal function and behavioural adaptation to neuropsychological stress. Further corroborating this claim is the phenomenon that these epigenetic changes correlate with the behavioural consequences of trauma exposure. Thereby, epigenetic modifications provide a putative molecular mechanism by which the behavioural phenotype and transcriptional/translational potential of genes involved in HPA axis regulation can change drastically in response to environmental challenges, and appear an important target for treatment of stress-related disorders. However, improved insight is required to increase their therapeutic (drug) potential. Here, we provide an overview of the growing body of literature describing the epigenetic modulation of the (primarily neuroendocrine) stress response as a consequence of adult life stress and interpret the implications for, and the challenges involved in applying this knowledge to, the identification and treatment of stress-related psychiatric disorders.

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The National Institutes of Health Neurobiobank: A Federated National Network of Human Brain and Tissue Repositories

Cited by 14 publications

References 0 publications

The Study of Postmortem Human Synaptosomes for Understanding Alzheimer’s Disease and Other Neurological Disorders: A Review

The Study of Postmortem Human Synaptosomes for Understanding Alzheimer’s Disease and Other Neurological Disorders: A Review

National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies

Epigenetic programming of the neuroendocrine stress response by adult life stress

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