The Natural Growth Rate of Skull Base Meningiomas Compared With Non-Skull Base Meningiomas

Abstract

In the present study, the authors assessed the differences in natural growth rates between skull base and non-skull base meningiomas by meta-analysis. Studies investigating meningioma growth rate were compiled from PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature database, and the China National Knowledge Infrastructure databases. A systematic review and meta-analysis of the collected literature were conducted using Stata 12.0 software. A total of 7 observational cohort studies, including 361 patients with untreated meningiomas, were included in the study. Meta-analysis showed that the weighted mean difference for absolute growth rate (years), relative growth rate (years), and doubling time (month) were 0.42 (95% confidence interval [CI]: 0.20–0.64, P <.0001), 1.08 (95%CI: 0.85–1.32, P <.0001), and −0.56 [95%CI: (−0.78)–(−0.33), P <.0001)] respectively. These findings indicate that the natural growth rate of skull base meningioma is less than that of non-skull base meningioma.

Comparison of Active Surveillance to Stereotactic Radiosurgery for the Management of Patients with an Incidental Frontobasal Meningioma—A Sub-Analysis of the IMPASSE Study

“…These driver mutations in frontobasal meningiomas are associated with a lower risk of recurrence after surgery and may also lessen their growth potential. Overall, skull base meningiomas were shown to grow more slowly than non-skull base meningiomas; in a meta-analysis of seven studies, the absolute growth rate of skull base meningiomas was 0.42 cm 3 /year less than that of non-skull base meningiomas [ 15 ]. In a retrospective study of 113 patients, only 15 (39.5%) of 38 skull base meningiomas showed growth, whereas 56 (74.7%) of 75 non-skull base meningiomas showed growth [ 16 ].…”

Cerebral venous revascularization in meningioma surgery

“…Принимая во внимание медленный рост менингиом, особенно конвекситальных (0,1-0,3 см 3 / год), можно заключить, что у венозной системы есть время для перестройки кровотока [3,30,31]. В то же время при удалении опухоли, вызывающей краевую или субтотальную окклюзии синуса, может возникнуть резкий дефицит венозного оттока.…”

Molecular determinants of outcomes in meningiomas

“…Though atypical and anaplastic may have over double the growth rate of grade 1, they may be comparable to one another (54). Besides grading, meningiomas in different locations may have different growth patterns, with one meta-analysis suggesting that skull base meningiomas grow significantly slower than other locations (55). If significant growth of a presumed meningioma is discovered or the lesion is symptomatic at time of diagnosis, treatment is warranted if the patient is otherwise a good candidate.…”