2020
DOI: 10.1530/erc-20-0136
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The natural history and treatment of non-functioning pituitary adenomas (non-functioning PitNETs)

Abstract: Non-functioning pituitary adenomas, recently alternatively-termed pituitary neuroendocrine tumours (NFpitNETs), are mostly benign neoplasms that are not associated with a hormonal hypersecretory syndrome. The clinical spectrum of NFpitNETs varies from completely asymptomatic to the development of panhypopituitarism and manifestations attributed to mass effects on nearby structures. NFpitNETs follow generally an indolent course, but in 5%-10% of cases they exhibit more aggressive behavior, characterised by rapi… Show more

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Cited by 37 publications
(27 citation statements)
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“…For NFPAs, the symptoms are instead caused by mass effect of the growing tumor. Due to the absence of hormone hypersecretion, these often slowly growing tumors are considerably larger in size than functioning tumors at the time of diagnosis 74 . The most typical symptom is visual disturbances due to compression of the optic nerves or the optic chiasm, but in giant adenomas, also the hypothalamus or the frontal lobes may be affected 70 .…”
Section: Clinical Presentationmentioning
confidence: 99%
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“…For NFPAs, the symptoms are instead caused by mass effect of the growing tumor. Due to the absence of hormone hypersecretion, these often slowly growing tumors are considerably larger in size than functioning tumors at the time of diagnosis 74 . The most typical symptom is visual disturbances due to compression of the optic nerves or the optic chiasm, but in giant adenomas, also the hypothalamus or the frontal lobes may be affected 70 .…”
Section: Clinical Presentationmentioning
confidence: 99%
“…In the past, radiotherapy (RT) was regularly administered postoperatively in order to prevent recurrence or growth of residual tumor 74 . The two different RT modalities used today are external beam radiation therapy (EBRT, conventional radiotherapy) or stereotactic radiosurgery (SRS) that delivers a single high dose or fractionated doses (FSRT).…”
Section: Radiotherapymentioning
confidence: 99%
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