The natural history of cartilage defects in people with knee osteoarthritis

Davies‐Tuck, Miranda; Wluka, Anita E.; Wang, Yuan‐Yuan; Teichtahl, Andrew; Jones, Graeme; Ding, Changhai; Cicuttini, Flavia Maria

doi:10.1016/j.joca.2007.07.005

Cited by 232 publications

(192 citation statements)

References 43 publications

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“…Early joint structural changes such as cartilage defects, loss of cartilage volume, subchondral bone expansion and bone marrow lesions are present prior to the onset of joint symptoms and clinical OA [18]. Bone expansion in the tibial subchondral area play an initial role in the aetiology of knee cartilage defects and cartilage loss.…”

Section: Discussionmentioning

confidence: 99%

“…These defects tend to progress in symptomatic knee OA. Prevention of cartilage damage or reducing their severity by intervention may retard OA progression [18]. Inadequate levels of serum 25-OHD in patients with knee OA is of major concern.…”

Section: Discussionmentioning

confidence: 99%

“…Loss of knee joint cartilage, which starts at about the age of 40 years [18], progresses incrementally with age as in the normal population, and at a mean age of 57 years approximately two thirds of the joint cartilage is damaged. Identification of high risk subjects and modification of risk factors of subchondral bone such as correction of serum 25-OHD deficiency at this stage is expected to exert beneficial effects.…”

Section: Discussionmentioning

confidence: 99%

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Association between serum vitamin D deficiency and knee osteoarthritis

Heidari

Hajian‐Tilaki

2010

International Orthopaedics (SICOT)

108

100

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Background Insufficient levels of serum 25-hydroxyvitamin D (25-OHD) influence the knee joint cartilage and lead to development and progression of knee osteoarthritis (OA). The purpose of this study was to determine the status of serum 25-OHD levels in patients with knee OA compared with controls. Methods A total of 148 patients with knee OA and 150 controls were studied. Serum 25-OHD was measured by the ELISA method and concentrations<20 ng/ml were considered as deficient levels. Mann-Whitney U test was used for comparisons of means and logistic regression analysis with calculation of odds ratio (OR) was applied to determine association. Results The mean ages of patients and controls were 60.2± 12.9 and 60.1±10.2 years, respectively (P=0.23). In the entire population the mean serum 25-OHD in OA patients was not significantly lower than controls (P=0.28), but in subgroup analysis the mean 25-OHD in OA patients aged <60 years was significantly lower than controls (23.8±18.8 vs. 34.5.±29.6 ng/ml, P=0.01). In this age group knee OA was significantly associated with serum 25-OHD deficiency which remained significant after adjusting for age and sex (adjusted OR=2.26, 95% CI 1.15-4.4, P=0.018). A greater association was observed in patients aged<55 years (OR=2.63, 95% CI 1.16-5.95, P= 0.01); whereas the association between OA and serum 25-OHD deficiency in patients aged ≥60 years did not reach a significant level. Conclusion These findings indicate a significant association between serum 25-OHD deficiency and knee OA in patients aged < 60 years and suggest serum 25-OHD measurement in any patient with symptoms suggestive of knee OA particularly at the initial stage of disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between serum vitamin D deficiency and knee osteoarthritis

Heidari

Hajian‐Tilaki

2010

International Orthopaedics (SICOT)

108

100

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“…Clinical studies have demonstrated that FDs can lead to cartilage degeneration, defect enlargement and tissue volume loss [55][56][57]. In addition, the abnormal strains that occur due to the presence of a FD are likely to make the tissue more susceptible to mechanical injury.…”

Section: Discussionmentioning

confidence: 99%

Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading

2013

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“…[1][2][3][4] The serum level of 25-hydroxy vitamin D depends on various parameters such as ultraviolet irradiation (determined by the time of day) to skin, skin pigmentation, season, [5][6][7] latitude, age, dietary habits, gender, obesity, and many others factors. [6][7][8][9] It is known that vitamin D has role in mineralization, demineralization, remodeling, and maintenance of bone. Therefore its deficiency may be implicated in the pathogenesis of osteoarthritis (OA).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency showed association with knee osteoarthritis in Tamilnadu population â€“ A pilot study

2020

IJOS

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Introduction: Aim of the study is to measure serum 25 -hydroxy vitamin D levels in patients with knee osteoarthritis in comparison with age matched healthy controls and also to assess the association of 25-OH vitamin with osteoarthritis. Materials and Methods:The study population consists of 240 patients divided into two groups, Group 1 and Group 2. Group 1 with 120 subjects with clinical features of knee osteoarthritis served as controls and Group 2 consists of 120 patients of patients diagnosed with knee osteoarthritis. Serum 25-OH vitamin D was measured in all the participants by the ELFA method and concentrations <10ng/ml was considered as deficient. Results: In Group 1, 57(46.5%) were males and 63 (53.5%) females, while in Group 2, 57(45.5%) were males and 63 (54.5%) females. Distribution of vitamin D status according to age, BMI and gender was also made and compared between the groups. Number of patients <60 years were 55 and 56 respectively in Group 1 and Group 2. Serum 25-OH vitamin D deficiency was observed in 67(55.8%) patients in Group 2 versus 15(12.5%) of Group B (P = 0.001). Further analysis of subgroups, revealed that the mean serum 25-OH vitamin D level in Group 2 aged <60 years was significantly lower than Group 1 (8.2 ± 1.1 vs. 9.2 ± 0.8 ng/ml, P < 0.05). Conclusion:The present study findings showed a significant association between serum 25-OH vitamin D deficiency and in patients with knee osteoarthritis aged < 60 years. Screening of serum 25 -OH vitamin D measurement in patients with symptoms suggestive of knee osteoarthritis is recommended as it showed association with knee osteoarthritis.

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The natural history of cartilage defects in people with knee osteoarthritis

Cited by 232 publications

References 43 publications

Association between serum vitamin D deficiency and knee osteoarthritis

Association between serum vitamin D deficiency and knee osteoarthritis

Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading

Vitamin D deficiency showed association with knee osteoarthritis in Tamilnadu population â€“ A pilot study

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