The natural history of Peyronie's disease

Grasso, Marco; Lania, Caterina; Blanco, Salvatore; Limonta, Giuseppe

doi:10.4321/s0004-06142007000300021

Cited by 26 publications

(19 citation statements)

References 19 publications

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“…Over the longest reported observation period, Grasso et al studied 110 men followed for at least 5 years (mean follow up 6.4 years). 7 In contrast to reports of shorter follow up durations, disease progression was more common with 68% of men < 50 years of age requiring surgical therapy and 31.5% of men > 50 years of age opting for surgical treatment. Collectively, the natural history studies related to Peyronie's disease suggest that plaquerelated pain improves and/or resolves in the majority of patients with time even in the absence of treatment.…”

Section: Natural Historymentioning

confidence: 80%

“…Collectively, the natural history studies related to Peyronie's disease suggest that plaquerelated pain improves and/or resolves in the majority of patients with time even in the absence of treatment. 1,[3][4][5][6][7] Conversely, spontaneous resolution or significant improvement of penile deformity is rare, and predictors of disease progression/resolution are inconsistent or absent. 6,7 As such patients with penile deformities that result in sexual dysfunction or distress should be counseled regarding treatment options that may influence the natural history of the condition and restore functionality.…”

Section: Natural Historymentioning

confidence: 99%

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2018 Canadian Urological Association guideline for Peyronie's disease and congenital penile curvature

Bella

Lee

Grober

et al. 2018

CUAJ

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Peyronie’s disease (PD) is a highly prevalent condition that affects the physical and psychosocial well-being and quality of life (QoL) for thousands of Canadian men. The specific etiology of PD remains poorly understood and there remains a paucity of randomized placebo-controlled trials evaluating treatment interventions.1-3 PD can be found in up to 8.9% of men, a remarkable increase in cited prevalence that is attributable to growing awareness (as historical data suggested a rate of less than 1%); the burden of disease is significant, and PD is often present in otherwise healthy men. The following guidelines were crafted by the committee with a full awareness of the limitations of the literature, and sought to provide actionable recommendations to guide PD care in the Canadian health system.

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Section: Natural Historymentioning

confidence: 80%

Section: Natural Historymentioning

confidence: 99%

2018 Canadian Urological Association guideline for Peyronie's disease and congenital penile curvature

Bella

Lee

Grober

et al. 2018

CUAJ

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“…Despite the occasional observational case series [1][2][3][4][5][6] reported in the literature, little is known about the natural history of Peyronie's disease. However, all these case series have varying drawbacks, as they have either had very small numbers [1][2][3] or have only been based on quality of life (QoL) questionnaires [4] or focussed on assessing relationship between age, co-morbidities [5], sonographic characteristics of the plaque and progression/stability of the disease [6].…”

Section: Discussionmentioning

confidence: 99%

“…However, all these case series have varying drawbacks, as they have either had very small numbers [1][2][3] or have only been based on quality of life (QoL) questionnaires [4] or focussed on assessing relationship between age, co-morbidities [5], sonographic characteristics of the plaque and progression/stability of the disease [6]. Although flaccid penile length has been measured [7] to study natural history, to date there are no studies of sequential measurements of erect penile length and deformity.…”

Section: Discussionmentioning

confidence: 99%

Is Penile Shortening Part of Natural History of Peyronie’s Disease?

Chitale¹,

Morsey²,

Sethia³

2010

TOUNJ

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Introduction/Aims: We have studied the natural history of Peyronie's disease with particular reference to erect (functional) penile length. To our knowledge this has so far not been documented.Methods: 21 men with stable Peyronie's deformity were followed up for 6 months when no active treatment was being offered. By inducing an artificial erection objective assessments of penile length and deformity were made on day 1 and at six months.Results: Measurable shortening in straight penile length was noticed in 6/21 (28.5%) of men (Mean: 0.92 cm), lengthening in 8/21 (38.09%) of men (Mean: 0.81 cm), while no change was noticed in the remaining 7 (33.3%).Angulation increased (worsened) in 5 (23.8%), decreased (improved) in 11 (52.38%) and showed no change in 5 (23.8%). There was no association between change in angle of deformity and change in penile length.Conclusions: In Peyronie's disease, a progressive reduction in penile length is noticed in up to a third of patients with stable disease and this is not necessarily associated with deteriorating angle of deformity.

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“…1À3 The untreated natural history of PD is one of progression with a study demonstrating worsening curvature during 5 years in 68% of patients younger than 50 years and in 31.5% of those older than 50 years. 4 Several treatment options have been described in the literature, including numerous oral, injection, topical and surgical therapies. However, despite the abundance of described treatments few studies have demonstrated consistent, statistically significant improvement in disease variables.…”

mentioning

confidence: 99%