The Natural History of Uremic Neuropathy

Albertazzi, A; Cappelli, P; Marco, Tiziana Di; Maccarone, M.; Paolo, B. Di

doi:10.1159/000415758

Cited by 21 publications

(18 citation statements)

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“…[7] Albertazzi et al documented the existence of 'uraemic neuropathy' as a possible cause for hearing loss in these patients. [23] In our study, a definite relation between hypertension and mean haemoglobin with hearing loss could not be established.…”

Section: Discussioncontrasting

confidence: 65%

Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Acharya¹,

Pati²,

Nayak³

2017

jemds

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BACKGROUNDHearing loss in chronic kidney disease is believed to be of multifactorial aetiology. Associated hypertension and diabetes mellitus, use of ototoxic drugs, haemodialysis and the changes in metabolic parameters are the various reasons implicated in hearing loss. Also, the prevalence, degree and patterns of hearing loss associated with Chronic Kidney Disease (CKD) reported by various studies differ significantly.The current study was conducted to assess the degree and type of hearing loss in CKD patients and to find out the association of duration of disease, haemodialysis and certain blood parameters with hearing loss. MATERIALS AND METHODS70 consenting patients of age 20 -60 yrs. with Non-Syndromic Chronic Kidney Disease referred from Nephrology Department were divided into 2 groups of 35 each, those with hearing loss i.e. HL group and without hearing loss i.e. non-HL group. Their demographic details and duration of the disease were recorded. They were subjected to physical examination, blood investigations and pure tone audiometry. Both groups were studied on the basis of above parameters. RESULTSIn the HL group, most patients (54.3%) were shown to have mild degree of hearing loss and higher frequencies were mostly affected. In addition, there was a comparatively stronger association of hyponatraemia and hypokalaemia with HL group than with non-HL group. Mean duration of the disease and haemodialysis was higher in HL group than in non-HL group. CONCLUSIONThe patients of Chronic Kidney Disease have mild degree of hearing loss, mostly at higher frequencies. A longer duration of the disease and haemodialysis are directly related to the hearing loss. Nonetheless, low serum sodium and potassium has a stronger relation with hearing loss group than in non-hearing loss group.

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Section: Discussioncontrasting

confidence: 65%

Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Acharya¹,

Pati²,

Nayak³

2017

jemds

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“…12,13 Effects of uremia and electrolyte imbalances have also been used to explain both nephropathy and hearing impairment. 14,15 Cosgrove et al 16 had suggested that prevalence of otopathology in patients with Alport Syndrome may be due to similar antigenic structure between basement membranes of glomeruli and cochlea.…”

Section: Discussionmentioning

confidence: 99%

Glomerular Filtration Rate and Urine Albumin to Creatinine Ratio Associated With Hearing Impairment Among Korean Adults With Diabetes

Cho

Kim²,

Choi

et al. 2016

Medicine

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The objective of this study was to examine the association of estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR) with hearing impairment among diabetic adults in Korea. The study was based on data from Korea National Health and Nutrition Examination Survey 2011 to 2012. Participants were 1206 diabetic adults, aged over 19 years, who completed audiometric testing supervised by nationally certified clinicians. Hearing impairment was defined in three grades: no hearing impairment (pure-tone average 0–25 dB), slight hearing impairment (26–40 dB), and disabling hearing impairment (>40 dB) in the better ear at frequencies 0.5, 1, 2, 3, 4 and 6 kHz. Using logistic regression, risk of hearing impairment was assessed after having controlled for confounding factors. Higher levels of ACR and lower levels of eGFR correlated with an increase in percentage of disabling hearing impairment both unilaterally and bilaterally (P < 0.001). Controlling for possible confounding covariates, odds ratios for hearing impairment showed tendency to increase in higher ACR groups (P for trend = 0.029). Similar pattern was examined between eGFR and hearing impairment (P for trend = 0.006). Odds ratios were 1.981 (1.146, 3.424) for ACR Q4 and 2.773 (1.286, 5.983) for eGFR < 60 mL/min. Fall in eGFR and rise in ACR correlated with severity of hearing impairment. The association existed independently of age, sex, body mass index (BMI), smoking, drinking, exercise, new onset of diabetes, education, income, mental stress, noise exposure, and metabolic syndrome.

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“…As the follow‐up period was for only 5 years, a longer follow‐up period may provide a more accurate estimation of nerve conduction parameter changes over time. Finally, because only healthy subjects were evaluated, our results may not as accurately predict the rate of change in NCS parameters in subjects with diseased nerves (e.g., peripheral neuropathy) or metabolic‐toxic disorders that may affect nerve function 1, 8, 12, 22…”

Section: Discussionmentioning

confidence: 99%

Effect of aging on sensory nerve conduction study parameters

2004

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Research evaluating the changes in nerve conduction with time has been limited to cross-sectional studies. We present a cohort study estimating how sensory nerve conduction study (NCS) parameters change with time when subjects are measured at two time-points. We evaluated 440 working adults by performing median and ulnar antidromic sensory NCS of both hands on two occasions, about 5.4 years (range, 4.3-7.0 years) apart. The rate of change in the NCS parameters was estimated using a mixed-models analysis controlling for each hand, gender, age, and body mass index (BMI). After controlling for gender, age, height, and BMI, the amplitudes of the median sensory nerve action potentials (SNAP) decreased by about 2.3 microV, peak latencies increased by 0.11 ms, onset latencies increased by 0.07 ms, and conduction velocities decreased by 1.1 m/s over 5 years. Corresponding values for the ulnar nerve were 1.75 microV, 0.06 ms, 0.04 ms, and 0.71 m/s, respectively. The findings are consistent with the findings of previous cross-sectional studies. The rate of change over time was not affected by hand (dominant versus nondominant hand), gender, age, or BMI at baseline. The rate of change seen with some of the median nerve parameters was significantly greater than that with the ulnar nerve.

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The Natural History of Uremic Neuropathy

Cited by 21 publications

References 0 publications

Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Pattern of Hearing Loss in Patients of Chronic Kidney Disease- A Prospective Comparative Study

Glomerular Filtration Rate and Urine Albumin to Creatinine Ratio Associated With Hearing Impairment Among Korean Adults With Diabetes

Effect of aging on sensory nerve conduction study parameters

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