The Natural PPAR Agonist Linoleic Acid Stimulated Insulin Release in the Rat          Pancreas

Lai, Min-Chuan; Teng, Tzu-Hua; Yang, Chi

doi:10.1292/jvms.13-0189

Cited by 14 publications

(8 citation statements)

References 23 publications

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“…P. alliacea contain an unsaturated free fatty acids named linoleic acid which can stimulate insulin secretion and increase glucose-induced insulin secretion in rats in a dose-dependent manner. 8 In addition, in a dose-dependent manner, allantoin compounds are also known can increase insulin secretion and decrease basal blood glucose level. 9 Tannins have also been observed to increase insulin activity and enhance the glucose uptake through mediators of the insulin-signalling pathways, especially in adipocyte.…”

Section: Discussionmentioning

confidence: 99%

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Hypoglicemic and Antioxidant Activity of Petiveria alliacea in Diabetic Rat Models

Gunawan

Soetjipto

Mustika

2020

BHSJ

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Introduction: Diabetes mellitus is a degenerative disease characterized by chronic hyperglycemia conditions in the body. Various complications of diabetes mellitus are caused by oxidative stress condition. Petiveria alliacea (P. alliacea) is a potential plant and easy to grow in hot regions. Leaf extracts of P. alliacea contain flavonoids and tannins which work as antidiabetic and antioxidant. In addition, other compounds found in P. alliacea leaf extracts like linoleic acid and allantoin show an increase in insulin secretion. Therefore, this study aimed to determine the antidiabetic activity of ethanolic extract of P. alliacea. Methods: We investigated the hypoglycemic and antioxidant effect of P. alliacea on STZ-induced diabetic rats. Rats were randomly divided into six groups named normal control, diabetes control, metformin (150 mg/kg/d), low dose of P. alliacea (90 mg/kg/d), intermediate dose (180 mg/kg/d), and high dose (360 mg/kg/d). Rats were orally given the treatment daily in the morning for fourteen days. At the end of the study, blood glucose level was measured and rats were sacrificed to measure blood malondialdehyde level.malondialdehydeResults: P. alliacea extract dose of 90 mg/kg and 360 mg/kg, and also metformin significantly decrease blood glucose levels. P. alliacea extract dose of 360 mg/kg was able to lower blood malondialdehyde level significantly which were not obtained on metformin. Conclusion: This finding suggests that ethanolic extract of P. alliacea possess antidiabetic effect at least on rats.

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Section: Discussionmentioning

confidence: 99%

“…Linoleic acid and allantoin can stimulate insulin secretion. 8,9 *Correspondence: mustikaarifa@yahoo.com Biomolecular and Health Science Journal. Available at https://e-journal.unair.ac.id/BHSJ DOI: 10.20473/bhsj.v3i1.19129…”

Section: Introductionmentioning

confidence: 99%

Hypoglicemic and Antioxidant Activity of Petiveria alliacea in Diabetic Rat Models

Gunawan

Soetjipto

Mustika

2020

BHSJ

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“…In contrast to the findings for active PAI-1 plasma concentrations and PAI-1 mRNA expression in adipose tissue, after 6 weeks of HFD, fasting insulin levels in serum and HOMA-IR both no longer differed from those found after consumption of the ND, suggesting that subjects might have metabolically adapted to the increased fat intake. Indeed, it has been suggested by the results of animal studies that certain fatty acids — for example, arachidonic acid, γ-linolenic acid, or linoleic acid — may alter insulin release (Gravena et al, 2002; Lai et al, 2013). It further was shown that a long-term intake of a HFD may be associated with a decrease of this effect (Lai et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, it has been suggested by the results of animal studies that certain fatty acids — for example, arachidonic acid, γ-linolenic acid, or linoleic acid — may alter insulin release (Gravena et al, 2002; Lai et al, 2013). It further was shown that a long-term intake of a HFD may be associated with a decrease of this effect (Lai et al, 2013). If similar effects were involved in the present study, and which molecular mechanisms are responsible for the reduction of insulin concentrations and HOMA-IR found when consuming the HFD for an extended period of time, remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Plasminogen Activator Inhibitor-1 is Regulated Through Dietary Fat Intake and Heritability: Studies in Twins

et al. 2017

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In different pathophysiological conditions plasminogen activator inhibitor-1 (PAI-1) plasma concentrations are elevated. As dietary patterns are considered to influence PAI-1 concentration, we aimed to determine active PAI-1 plasma concentrations and mRNA expression in adipose tissue before and after consumption of a high-fat diet (HFD) and the impact of additive genetic effects herein in humans. For 6 weeks, 46 healthy, non-obese pairs of twins (aged 18-70) received a normal nutritionally balanced diet (ND) followed by an isocaloric HFD for 6 weeks. Active PAI-1 plasma levels and PAI-1 mRNA expression in subcutaneous adipose tissue were assessed after the ND and after 1 and 6 weeks of HFD. Active PAI-1 plasma concentrations and PAI-1 mRNA expression in adipose tissue were significantly increased after both 1 and 6 weeks of HFD when compared to concentrations determined after ND (p < .05), with increases of active PAI-1 being independent of gender, age, or changes of BMI and intrahepatic fat content, respectively. However, analysis of covariance suggests that serum insulin concentration significantly affected the increase of active PAI-1 plasma concentrations. Furthermore, the increase of active PAI-1 plasma concentrations after 6 weeks of HFD was highly heritable (47%). In contrast, changes in PAI-1 mRNA expression in fatty tissue in response to HFD showed no heritability and were independent of all tested covariates. In summary, our data suggest that even an isocaloric exchange of macronutrients - for example, a switch to a fat-rich diet - affects PAI-1 concentrations in humans and that this is highly heritable.

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“…Our study further showed that higher proportions of n-6 PUFAs were associated 8 with a lower risk of T2D, concordant with a previous meta-analysis of prospective 9 cohort studies (44). The association may be partly mediated by increasing insulin 0 sensitivity through increasing cellular membrane fluidity (45,46), particularly of 1 skeletal muscle cells and hepatocytes (45,46), and by acting as ligands for 2 peroxisome proliferator-activated receptor gamma (47,48). These hypotheses are 3 supported by a meta-analysis of randomized feeding trials that showed improvements in glucose-insulin homeostasis for dietary PUFA compared to SFA or MUFA (49).…”

mentioning

confidence: 97%

Circulating metabolic biomarkers are consistently associated with incident type 2 diabetes in Asian and European populations – a metabolomics analysis in five prospective cohorts

Seah

Hong

Cichońska³

et al. 2021

Preprint

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Aims/hypothesis: We aimed to evaluate metabolic biomarkers in relation to incident type 2 diabetes (T2D) representing three major ethnic groups in Asia (Chinese, Malay, and Indian) and a European population. Methods: We used data from male and female adult participants of multiple cohorts, including two cohorts from Singapore (n = 6,393 Asians) consisting of ethnic Chinese, Malays, and Indians, and three cohorts of European-origin participants from Finland (n = 14,558). We used nuclear magnetic resonance to quantify 154 metabolic biomarkers in plasma collected at baseline and performed multivariable logistic regression to assess associations between the metabolic measures and risk of T2D with adjustments for age, sex, BMI and either fasting glucose or glycated haemoglobin (HbA1c). Results: Of 154 metabolic biomarkers, 59 were associated with higher risk of T2D in both Asians and Europeans (P < 0.0003; Bonferroni-corrected). These included branched-chain and aromatic amino acids and alanine, the inflammatory marker glycoprotein acetyls, total fatty acids, the proportion of monounsaturated fatty acids, apolipoprotein B, larger very low-density lipoprotein particle sizes, and triglycerides. A further 13 metabolic biomarkers were associated with lower T2D risk in both populations including proportion of omega-6 polyunsaturated fatty acids and larger high-density lipoprotein particle sizes. Associations were consistent within the Asian ethnic groups (Phet ≥ 0.05 for all 154 metabolic biomarkers) and largely consistent with the European population (Phet ≥ 0.05 for 128 of 154 metabolic biomarkers). Conclusions/interpretation: Metabolic biomarkers across a variety of biological pathways were consistently associated with T2D risk in three Asian ethnic groups and a European population.

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The Natural PPAR Agonist Linoleic Acid Stimulated Insulin Release in the Rat Pancreas

Cited by 14 publications

References 23 publications

Hypoglicemic and Antioxidant Activity of Petiveria alliacea in Diabetic Rat Models

Hypoglicemic and Antioxidant Activity of Petiveria alliacea in Diabetic Rat Models

Plasminogen Activator Inhibitor-1 is Regulated Through Dietary Fat Intake and Heritability: Studies in Twins

Circulating metabolic biomarkers are consistently associated with incident type 2 diabetes in Asian and European populations – a metabolomics analysis in five prospective cohorts

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