The Natural Treatment of Hypertension

Wilburn, Amanda James; King, Deborah S.; Glisson, James; Rockhold, Robin W.; Wofford, Marion R.

doi:10.1111/j.1524-6175.2004.03250.x

Cited by 29 publications

(21 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Garlic extract and its derivatives have hypotensive properties and can induce vasodilation in vivo and in vitro (6,(23)(24)(25). We therefore asked whether these compounds evoke vasodilation through a TRPA1-dependent mechanism.…”

Section: Garlic Compounds Act On Sensory Nerve Fibers To Produce Vasomentioning

confidence: 99%

Pungent products from garlic activate the sensory ion channel TRPA1

Bautista

Movahed

Hinman

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

758

585

View full text Add to dashboard Cite

Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many health benefits have been ascribed to Allium extracts, including hypotensive and vasorelaxant activities. However, the molecular mechanisms underlying these effects remain unknown. Intriguingly, allicin and DADS share structural similarities with allyl isothiocyanate, the pungent ingredient in wasabi and other mustard plants that induces pain and inflammation by activating TRPA1, an excitatory ion channel on primary sensory neurons of the pain pathway. Here we show that allicin and DADS excite an allyl isothiocyanate-sensitive subpopulation of sensory neurons and induce vasodilation by activating capsaicin-sensitive perivascular sensory nerve endings. Moreover, allicin and DADS activate the cloned TRPA1 channel when expressed in heterologous systems. These and other results suggest that garlic excites sensory neurons primarily through activation of TRPA1. Thus different plant genera, including Allium and Brassica, have developed evolutionary convergent strategies that target TRPA1 channels on sensory nerve endings to achieve chemical deterrence.inflammation ͉ pain ͉ TRP channel ͉ vasodilation ͉ natural products

show abstract

Section: Garlic Compounds Act On Sensory Nerve Fibers To Produce Vasomentioning

confidence: 99%

Pungent products from garlic activate the sensory ion channel TRPA1

Bautista

Movahed

Hinman

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

758

585

View full text Add to dashboard Cite

show abstract

“…In our study the possible effect can be caused by ascorbic acid component expected to be 20-23 mg, quite lower than the mentioned trial [6]. Ascorbic acid is reported to be one of the dietary supplements related with blood pressure decrease possibly preventing nitric oxide breakdown [7]. Citrus interdonato juice also includes flavonoids [8].…”

Section: Evaluation Of the Effect Of Citrus Lemon L "Enter" On Bloodmentioning

confidence: 57%

Evaluation of the Effect of Citrus Lemon L. “Enter” on Blood Pressure in Hypertensive Patients

Özünal¹,

Tahirbegolli²,

Üresin³

2017

JPP

View full text Add to dashboard Cite

This study aimed to evaluate the effectiveness of lemon juice to lower blood pressure. Twenty nine patients were included. Blood pressure measurements were done before (basal) and 5th, 15th and at 30th minute after lemon juice or equal volume of water intake. When compared with the basal values, patients who were given lemon juice had lower systolic blood pressure at 5th, 15th and 30th min. Control patients who were given water had lower systolic blood pressure at 5th and 15th, and diastolic blood pressure at 15th min. When compared with the basal values, patients who were given lemon juice had lower heart rate at 15th and 30th and control patients who were given water had decreased heart rate at 5th, 15th and 30th min. Both lemon juice and water decreased systolic blood pressure within first 15th minutes possibly due to doctor and environmental silent effect. These results do not support lemon juice intake.

show abstract

“…It is possible, even likely, that relevant clinical trials have been missed. However, the fact that this review is more complete than two recent articles [56,57] on similar topics might suggest that it is not wholly insufficient.…”

Section: Commentmentioning

confidence: 71%

Complementary/alternative medicine for hypertension: a mini-review

Ernst

2005

Wien Med Wochenschr

View full text Add to dashboard Cite

Many hypertensive patients try complementary/alternative medicine for blood pressure control. Based on extensive electronic literature searches, the evidence from clinical trials is summarised. Numerous herbal remedies, non-herbal remedies and other approaches have been tested and some seem to have antihypertensive effects. The effect size is usually modest, and independent replications are frequently missing. The most encouraging data pertain to garlic, autogenic training, biofeedback and yoga. More research is required before firm recommendations can be offered.

show abstract

The Natural Treatment of Hypertension

Cited by 29 publications

References 34 publications

Pungent products from garlic activate the sensory ion channel TRPA1

Pungent products from garlic activate the sensory ion channel TRPA1

Evaluation of the Effect of Citrus Lemon L. “Enter” on Blood Pressure in Hypertensive Patients

Complementary/alternative medicine for hypertension: a mini-review

Contact Info

Product

Resources

About