The nature of the transforming lymphocyte in chronic lymphocytic leukemia

Schweitzer, Marjan; Melief, C. J. M.; Eijsvoogel, V. P.

doi:10.1002/eji.1830030302

Cited by 43 publications

(3 citation statements)

References 19 publications

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“…Previous studies of the MLR stimulatory capacities of CLL lymphocytes have reported both normal (25)(26)(27) and decreased stimulatory capacity (28,29). However, it is apparent in all of the studies that when the data are recalculated on a per B-cell basis, the MLR generated by CLL subjects are abnormal.…”

Section: Discussionmentioning

confidence: 99%

Poor Mixed Lymphocyte Reaction Stimulatory Capacity of Leukemic B Cells of Chronic Lymphocytic Leukemia Patients Despite the Presence of Ia Antigens

Halper¹,

Fu²,

Gottlieb³

et al. 1979

J. Clin. Invest.

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A B S T R A C T The humana Ial-like aintigens, selectively expressed on B lymphocytes, are noow recognized to be closely associate(l with, or identical to, the genie prodlucts of the imaljor histocompatibility complex responsil)le for stimulation in the mixed lymphocyte reaction. The leuikemie B lymphocytes of patienits wvith chronie lylmphocytic leukemnia express these antigens very well. In the presenit stuidy they were readily dletected by several techniq(uies utilizing 1)oth allo-anid heteroanitiseral. However

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Section: Discussionmentioning

confidence: 99%

Poor Mixed Lymphocyte Reaction Stimulatory Capacity of Leukemic B Cells of Chronic Lymphocytic Leukemia Patients Despite the Presence of Ia Antigens

Halper¹,

Fu²,

Gottlieb³

et al. 1979

J. Clin. Invest.

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“…Rather, the findings are consistent with the view of Schweitzer et a1. 28 and of Wybran et a1.33 that the circulating T cells in typical cases of C.L.L. represent a normal subpopulation diluted in a large excess of neoplastic B lymphocytes.…”

Section: Discussionmentioning

confidence: 93%

Characterization of lymphocyte subpopulations in chronic lymphocytic leukemia

Rowlands

Daniele

Nowell̀

et al. 1974

Cancer

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B cell and T cell characteristics of circulating lymphocytes were studied in 13 patients with chronic lymphocytic leukemia (C.L.L.). Immunofluorescence of surface immunoglobulins and rosette formation using sensitized sheep red blood cells were employed to detect B cells. Rosette formation with untreated sheep red blood cells and in vitro PHA stimulation and cytogenetics were used to study T cells. The findings generally confirm the conclusions of others that C.L.L. usually represents a proliferative disorder of B cells, probably clonal in nature. In 11 of 13 cases the predominant cell surface immunoglobulin was IgM; in 1 case it was IgG, and in 1 case there was only a slight elevation in the incidence of IgM positive cells. In general, EAC rosette studies confirmed the observations made using immunofluorescence, but in one case this correspondence was apparent only after the incidence of EAC rosettes was increased by pretreatment of the C.L.L. cells with 2‐mercaptoethanol. In another case, the incidence of EAC rosette‐forming cells significantly exceeded the incidence of immunofluorescent cells, perhaps suggesting a variable expression of different surface markers on neoplastic cells in C.L.L. E rosette studies and PHA cultures indicated a decreased proportion of T cells in the peripheral blood of these patients, but suggested that the absolute number of T cells was not reduced. Further, kinetic and cytogenetic studies in PHA cultures demonstrated no qualitative abnormality in the circulating T cells in this disease, supporting the view that they represent a normal population diluted in a large pool of neoplastic B cells.

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“…In vitro proliferation of lymphocytes in response to stimulation with lectins, anti-lymphocyte serum (ALS), allogeneic cells (MLR), and Candida antigen was assayed as described by Schweitzer et al (25) and DuBois et al (26). Cultures in triplicate were performed in microtiter plates.…”

Section: Cell-mediated Immunitymentioning

confidence: 99%