The NCEP‐ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease

Luk, Andrea; Ma, Rong; So, Wing‐Yee; Xl, Yang; Kong, Alice P.S.; Ozaki, Risa; Ko, Gary T.C.; Chow, Chun‐Chung; Cockram, Clive S.; Chan, Juliana C.N.; Tong, Peter C.Y.

doi:10.1111/j.1464-5491.2008.02602.x

Cited by 23 publications

(19 citation statements)

References 31 publications

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“…However, the association of IDF-defined MS with ischemic stroke was not significant. Luk et al 30 reported that in patients with type 2 DM, the ATP III but not the IDF definition of MS, defined a subgroup of patients who had a higher risk of chronic kidney disease. In the Japan Diabetes Complication Study, which enrolled 1424 type 2 DM patients who were followed for 8 years for evidence of CAD and stroke, the IDF definition showed no improvement in the prediction of adverse CVD events in comparison with the ATP III and WHO definitions.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Chu

Pan

et al. 2011

Int J Impot Res

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There is growing evidence of a link between ED, metabolic syndrome (MS) and cardiovascular disease (CVD). The study was to explore the prevalence of MS using three different definitions (World Health Organization (WHO), International Diabetes Foundation (IDF) and Adult Treatment Panel III (ATP III)), and to compare the association of CVD in ED outpatients using these definitions. This study enrolled 254 participants with a mean age of 55.3±0.9 years (range, 21 to 81 years) with ED as diagnosed by International Index of Erectile Function score. All participants underwent MS evaluation based on the three criteria. Differences of MS prevalence, demographical characteristics, biochemical profiles, pro-inflammatory and inflammatory markers, echocardiographic characteristics and the association with Framingham cardiac risk score (FCRS) were compared. The presence of diabetes mellitus (DM) in the WHO group and high waist girth in the IDF group were significant because of the necessity of respective criteria. The MS prevalence in the WHO, IDF and ATP III groups was 30.7, 34.3 and 36.6%, respectively (P ¼ 0.367). The degrees of agreement among each definition were substantial to perfect. No significant findings in echocardiographic characteristics, biochemical, inflammatory and pro-inflammatory markers were noted. The FCRS showed borderline nonsignificant difference (17.9 ± 0.4, 16.8 ± 0.4 and 16.9 ± 0.4, P ¼ 0.079); however, the FCRS was more closely correlated with the WHO than with the IDF and ATP III (Spearman's correlation coefficients were 0.522, 0.531 and 0.462, respectively; P ¼ 0.021). In patients o 55 years of age and those who smoke, the Spearman's correlation in the WHO group was significantly higher than in the IDF and ATP III groups. The prevalence of the MS using different definitions in ED patients was not different. The WHO-defined MS was more closely associated with CVD.

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Section: Discussionmentioning

confidence: 99%

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Chu

Pan

et al. 2011

Int J Impot Res

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“…Previous studies have reported that the proportion of non-obese individuals among those with MS diagnosed according to the NCEP criteria is 9.7-18.9% in Europeans (23, 34), 7.6-35.6% in Asians except for Japanese (8,10,24,35,36), 25.4-33.6% in Japanese (20,22) and 31.3-32.6% in Asians with type 2 diabetes (6,25). The median of these values is higher among Asians than Europeans (32.5% vs. 14.3%).…”

Section: Discussionmentioning

confidence: 99%

“…The number of patients with ESRD has been increasing worldwide, with diabetic nephropathy recognized as the most significant cause of this increase (3), and hypertension, dyslipidemia and obesity are considered to independently damage the kidneys (4,5). A number of studies have recently focused on the relationship between metabolic syndrome (MS), the clustering of metabolic risk factors within the same individual and CKD (6)(7)(8)(9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Risk of Chronic Kidney Disease in Non-Obese Individuals with Clustering of Metabolic Factors: A Longitudinal Study

et al. 2015

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Objective The impact of the clustering of metabolic factors on chronic kidney disease (CKD) in non-obese individuals remains unclear. Methods We conducted a follow-up study of 23,894 Japanese adults (age, 18-69 years) who continuously received annual health examinations between 2000 and 2011. Obesity, high blood pressure, high triglycerides, low high-density lipoprotein (HDL) cholesterol and high fasting blood sugar were defined as metabolic factors, and CKD was defined as renal dysfunction (estimated glomerular filtration rate: <60 mL/min/1.73 m 2 ) or proteinuria (dipstick test: ! 1+). The association between the clustering of metabolic factors and CKD was assessed based on the presence or absence of obesity using a Cox proportional hazard model. Results Of 2,867 subjects with ! 3 metabolic factors, 650 (22.7%) were non-obese. These individuals were older and had higher metabolic risks than their obese counterparts at baseline. Among the entire cohort of 23,894 subjects, 1,764 developed renal dysfunction and 904 developed proteinuria during an average followup period of 7.8 years. The cumulative incidence of renal dysfunction was higher (22.1% vs. 16.1%), whereas that of proteinuria was lower (10.5% vs. 14.4%), among the non-obese subjects with ! 3 metabolic factors than the obese subjects with ! 3 metabolic factors after 11 years. The adjusted relative risk (RR) (95% confidence interval) of renal dysfunction was 1.54 (1.34-1.77) and 1.67 (1.35-2.07) for the obese and nonobese subjects with ! 3 metabolic factors, respectively. Conclusion Non-obese subjects with ! 3 metabolic factors, who are missed based on the essential criterion of obesity for metabolic syndrome, may have an equal or slightly higher risk of renal dysfunction than obese subjects with ! 3 metabolic factors.

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“…MS was diagnosed in older women who had three or more of the following criteria: abdominal obesity (UAC > 88 cm), TG values X ≥ 150 mg.dl-1, HDL-C values X <50 mg.dl -1 ; BP values ≥ 130/85 mmHg, or taking antihypertensive treatment, and plasma fasting glucose levels 110 ≥ mg.d l-1 (Luk et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

“…Metabolic syndrome (MS) is a health complication that has been strongly associated whit the elder population (Bener et al, 2010), which is a disease of complex nature, consisting of five major clinical components: abdominal obesity, atherogenic dyslipidemia, elevated blood pressure and insulin resistance without glucose intolerance in potentially harmful combinations that significantly rise cardiovascular risk (Luk et al, 2008), various authors report straight associations of the MS with an endomorphic somatotype (Gordon et al, 1987;Koleva et al, 2002;Herrera et al, 2004;Kalichman et al, 2004;Buffa et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Agility and Dynamic Balance in Elderly Women with Endomorphic Mesomorph Somatotype with Presence or Absence of Metabolic Syndrome

et al. 2012

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SUMMARY:Physical function declines in efficiency with advancing age, contributing to disability. Furthermore, metabolic syndrome is a common illness in elderly populations, somatotayping is a technique for description of the physique and can establish a relation with performance and pathology. The aim of this work was to compare the agility, dynamic balance in elderly women with endomorphic mesomorph somatotype with presence or absence of metabolic syndrome. A sample of 18 volunteers was obtained (age 66.5±4.7 years old), all were elderly sedentary women. They were assessed whit anthropometric variables in accordance with ISAK protocol in order to determine Heath & Carter somatotype; presence of metabolic syndrome they were evaluated according with the NCEP ATP-III, the agility and dynamic balance was assessed with the functional test Time Up and Go (TUGT). Mean of somatotype in subjects with absence or presence of metabolic syndrome was 6.2-7.9-0.2 and 6.5-8.7-0.1 respectively; Shapiro-Wilk test checked the normality of the distribution in the functional test Time Up and Go, in the group with absence or presence of metabolic syndrome, based on its normality distribution for the intergroup comparison, the Student t test was applied, the significance level, utilized was 95% (P≤ , 0.05) for the sample assessed without metabolic syndrome, the execution time of the functional test TUGT was better in spite of the same somatotype intergroup. The pathological components of metabolic syndrome can be related whit dysfunctional mobility in elderly women.

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The NCEP‐ATPIII but not the IDF criteria for the metabolic syndrome identify Type 2 diabetic patients at increased risk of chronic kidney disease

Abstract: In Type 2 diabetes, NCEP-ATPIII, but not the IDF definition of MetS, identifies a subgroup of patients who have a higher risk of CKD.

Cited by 23 publications

References 31 publications

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Risk of Chronic Kidney Disease in Non-Obese Individuals with Clustering of Metabolic Factors: A Longitudinal Study

Comparison of Agility and Dynamic Balance in Elderly Women with Endomorphic Mesomorph Somatotype with Presence or Absence of Metabolic Syndrome

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