The necessity to revise Koch’s postulates and its application to infectious and non-infectious diseases: a mini-review

Hosainzadegan, Hasan; Khalilov, Rovshan; Gholizadeh, Pourya

doi:10.1007/s10096-019-03681-1

Cited by 19 publications

(11 citation statements)

References 19 publications

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“…Based on these findings, of HTLV-1 and HTLV-2 expression, it could be reinforced the hypothesis of ionizing radiation protagonism in the activation of host cell integrated HTLV-1/2 genes [77]. In vitro and ex vivo studies aim to explain in vivo phenomena which accounts for Koch postulates [78] that is under review, so it would infer, for example, that virus associated cytopathology and related dysregulated cell signaling, not necessarily and definitively prove the etiological role played by some viruses in cancer etiology. As already stated, environmental factors and host genetic background are associated with genesis of cancer and, why not contributing to viral genes expression?…”

Section: Discussionmentioning

confidence: 76%

Putative oncogenic viruses: Some data on Brazilian subjects

Tenorio¹,

Bretas²,

Bernardes³

et al. 2021

Integr Cancer Sci Therap

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The concepts of cancer etiology have changed over the years, mainly based on molecular epidemiology studies and bioinformatics approaches. Until relatively recently the most accepted theory of cancer etiology has dealt with the accumulation of gene mutations and the consequent cognate proteins dysfunction, but now some authors have argued against the proposed theory. The additional role of noncellular genes in the cause of malignancy, associated to environmental factors and host genetic background, has been proposed and mostly accepted by the scientific community. Some of our data from human populations in Brazil concerning cancer epidemiology, molecular and serological surveys, were conducted looking for the detection of putative oncogenic viruses, as the Human T-cell Lymphotropic virus/ HTLV-1/2, Human Papillomavirus/HPV, the Mouse or Human Mammary Tumor Virus/MMTV, the Human Endogenous Retrovirus/HERVs and the Hepatitis C virus/HCV, in human, healthy and malignized, tissues. Generally, research work around the world suggests that 10 to 20 % of all human cancers are etiologically linked to oncogenic viruses, so if the presence of exogenous or endogenous virus sequences in the human DNA has any significancy in the cancer etiology, it deserves further and continuous research work and discussion.

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Section: Discussionmentioning

confidence: 76%

Putative oncogenic viruses: Some data on Brazilian subjects

Tenorio¹,

Bretas²,

Bernardes³

et al. 2021

Integr Cancer Sci Therap

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“…Koch's postulate was fundamental to the identification of disease-causing microorganisms [86]. In short, the strategy of isolating and cultivating the potential pathogen, and inoculating it into a healthy organism to confirm the symptoms of the disease, brought many advances to the study of infectious diseases [87].…”

Section: Metagenomicsmentioning

confidence: 99%

Oil Palm Fatal Yellowing (FY), a Disease with an Elusive Causal Agent

Bittencourt¹,

Lins²,

Boari³

et al. 2022

Elaeis Guineensis

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Fatal yellowing disease (FY) is a bud rot-type disease that severely affects oil palm plantations in Latin America. Since 1974, when it was first reported in Brazil, this disorder has been responsible for severe economic losses in the oil palm industry; and, for nearly 50 years, several studies have tried to identify its causal agent, without success. The etiological studies regarding FY in oil palm explored either biotic and abiotic stress scenarios, in a single or combined manner. Most recently, the hypothesis in favor of one biotic cause has lost some grounds to the abiotic one, mainly due to new insights regarding deficient aeration in the soil, which reduces the potential for oxy-reduction, causing changes in the ionic composition of the soil solution. This review presents an overview of the history of this disease and the several efforts done to fulfill Koch’s postulates over the last 40 years, besides discussing recent studies that revisited this subject using some omics technics. We conclude by discussing further uses of omics via a multi-omics integration (MOI) strategy to help finally find out what is really behind the genesis of FY. Finding this elusive causal agent of FY out will allow either the development of a more efficient diagnostic tool and the advance in studies trying to find out the source of the genetic resistance hidden in the genome of the American oil palm.

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“…Asimismo, con la finalidad de verificar si el aislamiento fitopatógeno obtenido desarrollaba sintomatología similar a la observada en la planta afectada, se realizaron pruebas de patogenicidad (Hosainzadegan et al, 2020). En este caso se desinfectaron externamente hojas y tallos de plantines de yerba mate orgánicos de 25 cm de altura, y se realizaron lesiones mecánicas superficiales en estos tejidos vegetales, con la ayuda de un bisturí estéril.…”

Section: Patogenicidad Del Microorganismo Fitopatógenounclassified

CAPACIDAD BIOCONTROLADORA DE AISLAMIENTOS NATIVOS DE Trichoderma sp. CONTRA EL HONGO FITOPATÓGENO Alternaria alternata, AISLADO DE YERBA MATE (Ilex paraguariensis Saint Hil.)

Castrillo¹,

Bich²,

Sioli³

et al. 2021

Chil. j. agric. anim. sci.

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Los hongos fitopatógenos afectan a cultivos agrícolas, como la yerba mate (Ilex paraguariensis Saint Hil.). Una alternativa innovadora para el control de plagas es el empleo de hongos biocontroladores del género Trichoderma. Los objetivos del presente trabajo fueron aislar los agentes fúngicos causantes de lesiones foliares en yerba mate, y evaluar la capacidad antagónica de los aislamientos nativos de Trichoderma sp. frente a patógenos en este cultivo. A partir del corte, desinfección y siembra del tejido vegetal enfermo, se aisló e identificó morfológica y molecularmente un hongo fitopatógeno perteneciente a la especie Alternaria alternata. Se ensayaron pruebas de patogenicidad en plantas de yerba mate por triplicado. Se realizaron lesiones mecánicas superficiales en ellas y se inoculó el aislamiento fitopatógeno obtenido (conidios y micelio) para evaluar su capacidad fitopatógena. Se determinaron nuevas variantes de cultivo dual para evaluar la capacidad antagónica biocontroladora en condiciones in vitro. Se evaluó la capacidad biocontroladora in vitro de 30 aislamientos de Trichoderma frente al aislamiento fitopatógeno obtenido. Como control positivo se utilizó una cepa aislada de un producto fungicida comercial a base de T. harzianum. Se determinó que 18 de los 30 aislamientos de Trichoderma lograron inhibir en más del 50% el crecimiento del fitopatógeno A. alternata y presentaron diferencias estadísticamente significativas con respecto al

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The necessity to revise Koch’s postulates and its application to infectious and non-infectious diseases: a mini-review

Cited by 19 publications

References 19 publications

Putative oncogenic viruses: Some data on Brazilian subjects

Putative oncogenic viruses: Some data on Brazilian subjects

Oil Palm Fatal Yellowing (FY), a Disease with an Elusive Causal Agent

CAPACIDAD BIOCONTROLADORA DE AISLAMIENTOS NATIVOS DE Trichoderma sp. CONTRA EL HONGO FITOPATÓGENO Alternaria alternata, AISLADO DE YERBA MATE (Ilex paraguariensis Saint Hil.)

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